John D. Helmann

Professor. Bacillus subtilis physiology and stress responses (metal homeostasis, redox stress, antibiotic resistance & cell envelope). EIC of Mol Microbiol.

[The Pi Lab @hualiang2018]

Curious about organelle biogenesis in bacteria 🦠🔬Check out our review on bacterial organelles and their role in iron physiology @MolMicroEditors https://t.co/8RermOtNf6

[Sáenz Lab @LabSaenz]

🥳A tuneable minimal cell membrane reveals that two lipid species suffice for life: https://t.co/Vf6bLzkdG7. We chemically minimized the membrane of the Minimal Cell...they survived, but with some interesting shapes, like this 'Death Star' phenotype @Ijustice555 @JCVenterInst

[Paul Babitzke @BabitzkePaul]

I am pleased to announce that our paper describing the role of NusG-dependent RNA polymerase pausing on the function of 5 riboswitches is now published in NAR.
https://t.co/QnplSHwVZp

[Benjamin Ezraty @EzratyB]

A new study in PNAS explores the connection between methionines and copper, with a focus on CueO. A collaboration between @lcb_officiel and @BIP8_Marseille 🍾🍾
Methionine-rich domains emerge as facilitators of copper recruitment in detoxification systems https://t.co/rVD6I9KSIW

[bioRxiv Microbiology @biorxiv_micrbio]

The evolution and functional significance of the programmed ribosomal frameshift in prfB https://t.co/WAsq0mZQ3D #biorxiv_micrbio

[Srujana Samhita Yadavalli @ScarletSam]

🧵 Exciting new findings on bacterial stress response regulation, driven by small proteins (≤50 amino acids). Big shoutout to the amazing team behind this work led by @vsangeev. Read the full study here: https://t.co/tGZNSXlrAr

[Jörg Stülke @JorgStulke]

Read the new story of @WarnekeRobert on coenzyme A biosynthesis in Bacillus subtilis and the identification of a novel metabolite, cysteinopantetheine!
Excellent collaboration with @c_elfmann @IFeussner and teams!
@mbiojournal @uniGoettingen #subtiwiki

https://t.co/KgQrWVAZsb

[Doerr Lab @DoerrLab]

Our new paper out in @PLOSPathogens today: https://t.co/K68SlqMCjc We find that resistance/tolerance to antimicrobial peptides is slightly more complex and dynamic than your "average" antibiotic resistance. Nice work by @AndyMurtha et al.!

[George O'Toole (he/him/his) @GeiselBiofilm]

New in JB: Kochanowsky, Vedantam et al. show that Clostridioides difficile deploys a superoxide reductase to resist the effects of oxygen.
https://t.co/Ipmazk5XF3
@ASMicrobiology @JBacteriology

[Jennifer Goff @JLGoff_PhD]

We have a new paper out!

Deeply branching Bacillota species exhibit atypical Gram-negative staining | Microbiology Spectrum https://t.co/pEiAMtPUPi

[Akos T. Kovacs @EvolvedBiofilm]

Membrane depolarization kills dormant Bacillus subtilis cells by generating a lethal dose of ROS

@NatureComms from @HamoenLeendert
with @HenrikStrahl @KursadTurgay

https://t.co/PDMGCeokha

[Joseph E. Peters @JoePetersLab]

Very excited that this collaborative project is now published. This work was championed by Dr. Yu Tang @Tangyu0901 (Tongji University School of Medicine) and started during a visit to my lab. https://t.co/yxCFILNNDR 1/N

[HarsheyLab @harsheylab]

https://t.co/qAFlHtetAq

@BlastMeetings @MolMicroEditors

[Olivia Paxie @olivia_paxie]

I’ve felt more than lucky to be able to tour around the US! Thanks to @JohnHelmann and his whole lab for being so welcoming and talking some great science (and not science!) with me this week 🧬👩‍🔬

[Cecilia Martinez-Gomez @CeciMGLab]

Finally published! Check out the final version of our paper describing the discovery of methylolanthanin, a lanthanide metallophore secreted by methylotrophs! https://t.co/mPMBUTpMH3

[Julia Johanna Griese @GrieseJulia]

The long-awaited structure of Bacillus MntR bound to DNA! While structures of iron-sensing DtxR family members bound to DNA have been known for decades, the DNA complexes of manganese sensors have long eluded structure elucidation. Cryo-EM to the rescue!

[bioRxiv Microbiology @biorxiv_micrbio]

N-acetyl-transferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in M. marinum https://t.co/LibqfJpAro #biorxiv_micrbio

[Daniel Lopez @lopesrra]

A huge step in understanding the biological role of flotillin and membrane microdomains. Led by our very own Marta Ukleja 🇵🇱🙌🙌🙌 with the help of @CavaLab_MIMS, @mateus_lab and (twitterless) Ana Eulalio :-). @CaixaResearch funding.
https://t.co/UDDkm1mfTv

[John D. Helmann @JohnHelmann]

Excited to see this detailed view of MntR-oligomerization that is key for Mn-activated transcription in B. subtilis!
Work led by Shivani Ahuja and Arthur Glasfeld.

Structural basis for transcription activation through cooperative recruitment of MntR https://t.co/yZs6ni2P9j

[Eric Skaar @EricSkaar]

A family of DNA glycosylases in bacteria that repairs interstrand DNA crosslinks, protects against acid, and is involved in infection. New work from @DKunk and @YujuanCai in collaboration with @BFEichman @PNASNews https://t.co/cH27BkOMdI