Yesu

[The Better India @thebetterindia]

For years, Kala-Azar was a death sentence for some of India’s poorest families.

And treatment itself felt like punishment.
15 injections. Every alternate day.
A drug that sometimes caused dangerous heart complications.

For many families, surviving the disease wasn’t the only battle, a month away from work often meant losing the income that kept food on the table.

Prof. Shyam Sundar from Banaras Hindu University looked at this reality and asked:
What if one dose is enough?

In 2010, his landmark study in the New England Journal of Medicine showed that a single-dose liposomal amphotericin B treatment could cure Kala-Azar with a 95.6% success rate.

One breakthrough changed everything.

He also helped introduce rapid diagnostic strip tests that cut detection time from weeks to minutes.

WHO updated treatment protocols.
The medicine that cost nearly ₹19,000 per vial started reaching India free through donation programmes.

Today, India has moved from battling Kala-Azar outbreaks to pushing toward elimination.
And behind that story is a professor who spent decades making sure poverty didn’t decide who lives and who dies.

#PadmaShri #HealthcareHeroes #MedicalInnovation #PublicHealth #IndiaNews

[Padma Shri, Kala Azar, Public Health, Medical Innovation]

[Kaushik Basu @kaushikcbasu]

My calculation suggests India’s consumer price inflation will rise. The mid-east war is a factor, but also India’s economy is not being managed well—The rupee has lost value in a way it needn’t have. This is a reminder that policymaking needs professionals, not politicians.

[Pope Leo XIV @Pontifex]

Deep inner suffering inevitably arises when the human person is reduced to performance, consumption, or a statistical datum. Many young people today live under the yoke of expectations to perform, immersed in an exasperated competitiveness that generates anxiety, fear of not measuring up, and disorientation.

[Yesu @yesuy]

@suekhim my daughter has been learning maths via math academy.. it seems to have a progressive adaptive learning.. happy so far with the progress.. curious to see if Koji can do it better

[Pope Leo XIV @Pontifex]

Artificial intelligences do not undergo experiences, do not possess a body, do not feel joy or pain, do not mature through relationships, and do not know from within what love, work, friendship or responsibility mean. Nor do they have a moral conscience, since they do not judge good and evil, grasp the ultimate meaning of situations, or bear responsibility for consequences. They may imitate or even simulate, but they do not understand what they produce, for they lack the affective, relational, and spiritual perspective through which human beings grow in wisdom. #MagnificaHumanitas

[Pope Leo XIV @Pontifex]

Humanity, created by God in all its grandeur, is today facing a pivotal choice: either to construct a new Tower of Babel or to build the city in which God and humanity dwell together. In Jesus Christ, this humanity in its grandeur becomes the Way, the Truth and the Life, opening the path for each of us to grow toward fullness. #MagnificaHumanitas
https://t.co/6i9MWs6LJl

[Yesu @yesuy]

What do you think — is this the new standard or too aggressive?

[Zeb Evans @DJ_CURFEW]

Today we reduced headcount by 22%. The business is the strongest it's ever been. So I think it's important to be direct about what I'm seeing and why.

First, I made this decision and I own it. I did it because the way to operate at the highest level of productivity is changing, and to win the future, ClickUp needs to change with it.

Second, this wasn't about cutting costs. Most savings from this change will flow directly back into the people who stay. We'll be introducing million-dollar salary bands. If you create outsized impact using AI, you'll be paid outside of traditional bands.

Most importantly, I have the deepest gratitude for those affected. We're doing this from a position of strength specifically so we can take care of people properly. Everyone affected receives a package aimed at honoring their contributions and easing the transition.

I only see two options: wait for this to play out gradually in the market or be honest about what I'm seeing and act proactively.

THE 100X ORGANIZATION
The primary change is that we're restructuring around what I call 100x org. The goal is 100x output. The roles required to build at the highest level are fundamentally different than they were a year ago.

Incremental improvements to existing systems won't get us there. We need new ones. That means creating enough disruption to rebuild rather than iterate on what's already broken.

The common narrative is that AI makes everyone more productive. It doesn't. Many of the workflows of today, if left unchanged, create bottlenecks in AI systems.

These roles will evolve. But waiting for that to happen naturally means falling behind now.

The 100x org is actually heavily dependent on people - infinitely more than today. This is only possible with 10x people that have embraced and adopted new ways of working.

THE BUILDERS, AGENT MANAGERS, AND FRONT-LINERS

— THE BUILDERS: 10X ENGINEERS
I don't think most companies have internalized what's actually happening with AI in engineering. The common narrative is that AI makes all engineers more productive. That may be true in isolation, but at an organization level - that is the farthest thing from reality.

Here's what we've validated recently at ClickUp: the great engineers, the ones who can orchestrate, architect, and review, are becoming 100x engineers. They're not writing code. They're directing agents that write code. The skill is judgment.

AI makes the best engineers wildly more productive, and everyone else using AI slows these engineers down.
Think about it - the bottlenecks are (1) orchestration - telling AI what to do, and (2) reviewing - what AI did. Everything is leapfrogged and no longer needed.
So who do you want orchestrating and reviewing code?

And how do you want your best engineers to spend their time?

If your best engineers are spending time reviewing other people's code, then this is inherently an inefficient bottleneck. These engineers can review their agent's code much faster than reviewing human code.

The new world is about enabling your 10x engineers to become 100x.

The wrong strategy is to push every engineer to use infinite tokens. Companies doing this are celebrating 500% more pull requests. But customer outcomes don't match the volume of code being generated.

I call this the great reckoning of AI coding, and every company will face this soon if not already.

More code is just another bottleneck to the best engineers, and ultimately to your company's impact as well.

— THE BUILDERS: 10X PRODUCT MANAGERS
Product management and design roles are merging.

Designers that have customer focus, become more like product managers.

And product managers that have intuition for UX become more like designers.

The bottleneck of user research is gone. It takes us just one mention of an agent to kickoff research and analyze results.

The bottleneck of product <> design iteration is also gone. The product builder iterates on their own, along with agents and skills that ensure alignment with quality and strategy.

Also controversial today - I believe that the wrong strategy is to have your PMs shipping code - that just introduces another bottleneck that the best engineers will waste their time on.

To be clear, PMs should be coding but they should do this in a playground to iterate, validate, and scope. That code should not go to production.

Everything outside of managing systems, orchestrating AI, and reviewing output becomes a bottleneck.
That's why the other roles that are critical along with these are the systems managers (to reduce bottlenecks) along with a bottleneck you can't replace - customer meeting time.

— THE SYSTEM MANAGERS
Ironically, the people that automate their jobs with AI will always have a job. They become owners of the AI systems - agent managers. We have many examples of these people at ClickUp.

The underlying systems in which we operate are absolutely critical to get right. I think most companies are delusional to think they can iterate on existing systems and compete in this new world.

You must create enough disruption so that old systems are deprecated entirely. If there's any definition for 'AI native' that's what it is.

— THE FRONT-LINERS
In a world that will become saturated with AI communication, the human touch will matter more than anything to customers.

This is a bottleneck that you shouldn't replace - even when agents are high enough quality to do video meetings.

One-on-one meeting time with customers is something that shouldn't be automated. The systems around the meetings should be - so that front-liners spend nearly 100% of their time with customers.

REWARDING 100X IMPACT
In a world where companies are able to do so much more with less, where does that excess money go?
In our case, much of the savings in this new operating model will flow directly back to those that enabled it.

We must reward people that create productivity accordingly. This aligns incentives on both sides. Plus, in a world where your best people create 100x impact, you can't afford to lose them.

You should aim to retain these employees for decades. The context they have and their ability to efficiently orchestrate and review will be nearly impossible to replace.

Compensation bands of today should be thrown out the door. We're introducing $1 million cash/year salary bands with a path available to nearly everyone in the company if they produce 100x impact by creating or managing AI systems.

THE FUTURE
Nearly every company will make changes like these. The ones that do it proactively will define what comes next.

The future is not fewer people. It's different work, new roles, and better rewards for those who embrace it. We're already seeing entirely new roles emerge, like Agent Managers, that didn't exist a year ago.

ClickUp is positioning to lead this shift, not just internally, but for our customers too. I've never been more certain about where we're headed.

[Cloudflare @Cloudflare]

Cloudflare's security team spent the last few weeks testing Anthropic's Mythos against fifty of our own repositories. What we learned about offensive AI, why faster patching is the wrong reaction, and what the architecture around vulnerabilities has to look like next. https://t.co/RSrRtIhgaV

[Demis Hassabis @demishassabis]

I’ve always believed the No.1 application of AI should be to improve human health.

That work started with AlphaFold, and now at @IsomorphicLabs with the mission to reimagine drug discovery and one day solve all disease!

We are turbocharging that goal with $2.1B in new funding.

[Yesu @yesuy]

@alokebajpai impressive.. how is the adoption of this so far Aloke.. Are the conversions better via this medium than the traditional browse? if possible, do share your learnings on this subject..

[Yesu @yesuy]

@crystal_kizor looks superb.. how do you plan for reptiles/insects not coming inside. I imagine due to the trees etc, that is a possibility..

[Dubai Media Office @DXBMediaOffice]

Dubai Metro Gold Line Project, the largest transportation project in Dubai, with a total cost of AED 34 billion.
@rta_dubai

[The White House @WhiteHouse]

The future of air travel has arrived. Today, @SecDuffy announced groundbreaking new airspace software that will modernize America’s skies and dramatically REDUCE delays.

The GOLDEN AGE OF TRAVEL IS HERE! ✈

[Pope Leo XIV @Pontifex]

Without a change of direction in the assumption of political responsibility, and without respect for institutions and international agreements, humanity's destiny risks being tragically compromised. God does not want this. His holy Name must not be profaned by the desire for domination, arrogance, or discrimination. Above all, it must never be invoked to justify death-dealing choices and actions.

[Pope Leo XIV @Pontifex]

Even more than in the past, it is clear today that the proliferation of armed conflicts is often driven by the exploitation of oil and mineral deposits, with no regard for international law or the self-determination of peoples.

[HH Sheikh Mohammed @HHShkMohd]

ضمن برنامجنا لجعل دبي أفضل مدينة للعيش في العالم بحلول 2040 .. اعتمدنا قبل فترة خطة دبي لتطوير الشواطئ بقيمة 3 مليارات درهم بهدف زيادة استيعاب شواطئ دبي للسياح والزائرين بنسبة 170%

وبدأ العمل .. ولم تتوقف فرق العمل عن الإنجاز ولم يحدث أي تباطؤ ولن يحدث..

تفقدت أحد مشاريع الاستراتيجية وهو "مشروع شاطىء الممزر" الذي أوشك على الانتهاء ليكون أجمل وجهة شاطئية للعائلات في دبي قادر على استيعاب 7 ملايين زائر سنوياً وعلى مساحة 4 ملايين قدم مربع ..

المشاريع مستمرة .. العمل لن يتوقف .. الوتيرة ستكون مضاعفة .. لدينا أجندة تنموية .. ونحن ملتزمون بأجندتنا.

والقادم سيكون أكبر و��جمل بإذن الله.

[Yesu @yesuy]

@RohanNayak2 @PocketFM_App Congratulations @RohanNayak2 🚀🚀

[Alfred Lin @Alfred_Lin]

MOST PEOPLE:
6-12 months
escalate → discuss → roadmap
“let’s circle back”

HEAT SEEKER:
1-2 days
isolate → fix → ship
“done”

[Pope Leo XIV @Pontifex]

Woe to those who manipulate religion and the very name of God for their own military, economic, and political gain, dragging that which is sacred into darkness and filth. #ApostolicJourney #Cameroon https://t.co/bKteFZ3iWE

[Iran in Ghana @IRAN_GHANA]

Dear Italy,
Your PM just defended Pope and lost an ally in Washington — the Commander in Grief, yet the most 'powerfool'man on earth.

We'd like to apply for the vacancy.

Our qualifications: 7,000 years of civilization, a shared love of poetry, architecture, and food that takes longer to prepare than Trump's attention span.

The only thing Iran and Italy have ever fought over is who invented ice cream. Faloodeh came first. Gelato came louder. We've been in a 'cold' war over this for 2,000 years.