Gaucher's Disease: A bone marrow aspirate shows lipid-laden macrophages AKA "wrinkled tissue paper" or "crumpled silk" (Gaucher cells). The BM aspirate may give you diagnostic clues to enzyme deficiencies and storage disorders. 🦴🩸🧬🔬 Image from @StanleySchrier & ASH Image Bank! #MedEd #Hematology #ASHImageBank #hemepath https://t.co/GoskTxyyWv
@KMirza@artsinyc
Case of Syringomatous Adenoma of Nipple 🍥🔬
A benign but infiltrative tumor of the nipple dermis that is, for all intents and purposes, nearly identical morphologically to low-grade adenosquamous carcinoma of the breast.
#PathX#PathTwitter#breastpath
CC372. ORGAN and DIAGNOSIS. The importance of clinical information is directly proportional to the value that morphology has without it. Their combination is extremely synergistic, but it is advisable to know how to handle them separately #cytopath
Cervical lymph node - The pattern tells us the patient’s history.
🧩Papillary Thyroid Carcinoma (PTC)
-BRAF V600E mutation (m/c mutation)
-True papillae with nuclear features (enlargement & chromatin clearing)
-Psammoma bodies, cystic changes and lymph node involvement is common.
This is the block cell.
Sheets with epitheliod cell morphology admixed with spindle cells. DOG1 and CD117 positive: GIST.
What tips can you add for the diagnosis of this tumor?
An interesting case from Course Director Dr. Alexandros Polydorides
https://t.co/F8RCZplycl
Clinical history: 67 F with prior appendectomy, now presenting with an implant in the mesentery of the jejunum
#PathX#PathTwitter
What actually is p120?
And why does it stain cytoplasmic in lobular carcinoma of the breast, but membranous in normal breast tissue and DCIS?
What actually changes at the molecular level that leads to this shift in staining? A short 🧵
Use of p53 immunohistochemistry can improve diagnostic agreement for differentiated vulvar intraepithelial neoplasia (dVIN): an international reproducibility study - Dasgupta - Histopathology - Wiley Online Library #openaccess#gynpath https://t.co/XHYAJq83tJ
We think of a "null" (complete loss) p53 immunohistochemical staining pattern in Barrett's esophagus with high-grade dysplasia, but this example of low-grade dysplasia shows it.
#GUpath bladder bx for patient with hematuria and erythematous patch
🔬sneaky "undermining" pattern urothelial CIS
(notice transition from benign at left)
Lymphocyte rich esophagitis in a pt with Crohn’s disease.
This is a common injury pattern seen in pts with systemic immune mediated disorders.
Other d/dx - infections, medications, motility disorders & reflux.
#GIpath