Yurii

Ph.D. Scientist (chemistry and biology), CEO @Chem_space
Passionate about #drugdiscovery, Lego, and Star Wars. Proud father of two.
Post own opinions.

[Yurii @ysmoroz]

@DrBinChen @EnamineLtd Hello! @EnamineLtd is fine. Maybe it is a vacation period.

[Yurii @ysmoroz]

Some personal experience about life during war in Ukraine
https://t.co/9DhXEcQDeC

[Yurii @ysmoroz]

Identification and Validation of New Interleukin-2 Ligands Using DNA-Encoded Libraries

#drugdiscovery #openscience #DEL

[Yurii @ysmoroz]

The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators

https://t.co/jgI5cOJIpQ

#drugdiscovery #openscience #medicinalchemistry

[Yurii @ysmoroz]

Discovery of Pyrazolo[3,4-d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation

https://t.co/OwKyQQSYj8

#drugdiscovery #openscience #inhibitors

[Yurii @ysmoroz]

Site-Specific Labeling of Endogenous Proteins Using CoLDR Chemistry

https://t.co/lJPzSs4op5

#proteins #openscience #drugdiscovery

[Yurii @ysmoroz]

Flipping the Switch: Innovations in Inducible Probes for Protein Profiling

https://t.co/87Tnp2X7EP

#proteins #drugdiscovery #OpenScience

[Yurii @ysmoroz]

Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs) - something interesting on the topic if targeted protein gegradation

https://t.co/o84SeFzHVY

#drugdiscovery #OpenScience #proteindegradation

[Yurii @ysmoroz]

Discovery of Novel Small Molecule Inhibitors Disrupting the PCSK9-LDLR Interaction

https://t.co/3YpkXWXUXB

#drugdiscovery #inhibitors #OpenScience

[Yurii @ysmoroz]

Identification of covalent inhibitors that disrupt M. tuberculosis growth by targeting multiple serine hydrolases involved in lipid metabolism

#openscience #drugdiscovery #covalentinhibitors

[Yurii @ysmoroz]

Really nice preprint by @LabSkiniotis - Structure Determination of Inactive-State GPCRs with a Universal Nanobody

https://t.co/qwKhnDTtrN

#GPCRs #drugdiscovery #openscience #CryoEM

[Yurii @ysmoroz]

Macrocyclic DNA-encoded chemical libraries: a historical perspective

https://t.co/MdKcubQJcW

#DEL #drugdiscovery #OpenScience #DNA

[Yurii @ysmoroz]

Microcrystal electron diffraction (MicroED) for the study of protein-ligand interactions and the potential for drug discovery

https://t.co/XckMlUeG98

#drugdiscovery #openscience #proteins

[Yurii @ysmoroz]

Not only in silico drug discovery: Molecular modeling towards in silico drug delivery formulations

https://t.co/zzUWjYPpMR

#drugdiscovery #openscience #computerscience

[Yurii @ysmoroz]

MS imaging of multicellular tumor spheroids and organoids as an emerging tool for personalized medicine and drug discovery

https://t.co/pvEE61j05j

#drugdiscovery #OpenScience

[Yurii @ysmoroz]

Design of a mutant selective epidermal growth factor receptor inhibitor, that spans both orthosteric and allosteric sites by @DanaFarber and @uni_tue

https://t.co/jUBxGEhlMy

#drugdiscovery #OpenScience #inhibitor

[Yurii @ysmoroz]

Artificial intelligence and machine
learning-aided drug discovery in central nervous system diseases:
State-of-the-art and future directions

https://t.co/0HWwpu8wrA

#AI #MachineLearning #OpenScience #drugdiscovery

[Yurii @ysmoroz]

Today came across an article, where scientists explore ethanol-triggered deactivation of lipid-enveloped viruses, like ebola, influenza, and #coronavirus. Based on the model virus Phi6.

https://t.co/rE4AILvWOA

#openscience #viruses

[Chemspace @Chem_space]

Chemspace Catalog is already updated!
Now you are able to search in more than 4.3 Billion molecules.
https://t.co/C4bdZxflcQ
.
#chemspace #organicchemistry #drugsynthesis #science #openscience #research #drugdiscovery #chemicals

[Yurii @ysmoroz]

An insight on effects of physicochemistry of the immunomodulatory drugs on lipophilicity, solubility, metabolism, permeability, intracellular bioavailability, and cell-based potency.
https://t.co/kBsOrmJ9Oi

#drugdiscovery #openscience #thalidomide