Disorder in protein structures is critical to their biological functions but can also contribute to diseases. Our work introduces a new way to characterize protein disorder in biological systems, complementing existing '-omics' approaches and computational prediction methods.
Researchers present a proteome-wide workflow using the bifunctional chemical probe TME to capture, enrich, and profile endogenous disordered proteins in cells.
@shouxiang_zhang@owyongtc@yuning_hong@LIMSLTU@latrobe
https://t.co/gm3AG6QHOw
Disorder in protein structures is critical to their biological functions but can also contribute to diseases. Our work introduces a new way to characterize protein disorder in biological systems, complementing existing '-omics' approaches and computational prediction methods.
Researchers present a proteome-wide workflow using the bifunctional chemical probe TME to capture, enrich, and profile endogenous disordered proteins in cells.
@shouxiang_zhang@owyongtc@yuning_hong@LIMSLTU@latrobe
https://t.co/gm3AG6QHOw
Out today @naturemethods! Excited to share our work on a new method (RUBICON) based on a chemical probe to target in situ, enrich and profile endogenous disordered proteins in cells, including #IDPs and those that acquire disorder. #ozchem#proteostasis
https://t.co/0PNZca8y9d
1/2 π¬ Congratulations to LIMS & @SABE_Latrobeβs A/Prof Yuning Hong, Dr Shouxiang Zhang and Dr Tze Cin Owyong, whose world-first research creating a chemical tag to study disordered proteins in living cells has been published in @naturemethods! Read more: https://t.co/C2bvkWY1TI
Researchers present a proteome-wide workflow using the bifunctional chemical probe TME to capture, enrich, and profile endogenous disordered proteins in cells.
@shouxiang_zhang@owyongtc@yuning_hong@LIMSLTU@latrobe
https://t.co/gm3AG6QHOw
Finally, heartfelt thanks to the anonymous reviewers for their positive feedback and constructive comments, helping us maximize the potential of our data, to @naturemethods & @DrArunimaSingh for the opportunity - an absolutely delightful experience to work with them.
The way towards Single-Molecule Temporal Omics, exploring the future of #nanopore in cutting-edge temporal omics @naturemethods Many thanks to Mengyin @li_mengyin and Rujun@εζΉη§ε€§ https://t.co/WK4XbSISJV
Great evening with our fantastic @LIMSLTU@latrobe colleagues at the @TheASMR1 Victorian Gala Dinner. Congratulations and thank you ASMR medallist @MattDun17 for a moving and inspirational talk!
MCCB 2025: Drug Discovery in Darwin! Present research, network with experts, and explore innovations. Early bird registration open!
π https://t.co/LEF0CuKfrm
#RACI#ozchem#BOD1640