niki sinclair

[niki sinclair @zckpheobe]

@zaquanisqandar it depends on your meds jugak, cuba tny dgn mna2 AI apps. mmg jwpn suruh refer dgn dr dlu. jgn sukahati ambil tkut ubat yg kita dh consume hari2 tk function well.

[niki sinclair @zckpheobe]

@facepjmoff can i have em besty?

[Interesting AF @interesting_aIl]

A recent breakthrough might provide a ‘functional cure’ for HIV

Scientists at Caring Cross infused immune cells engineered to target HIV, and after 2 patients were injected, the virus was undetectable

[Science girl @sciencegirl]

A major challenge in curing HIV/AIDS is that the virus can hide inside human cells by inserting its genetic material into them. In this inactive state, it forms hidden “viral reservoirs” that are difficult for the immune system and current medications to detect or remove. Researchers are studying an internal immune sensor called CARD8 that can recognize when HIV becomes active inside a cell.

Normally, HIV avoids triggering this sensor because an important viral enzyme becomes active only after the virus leaves the infected cell. Scientists have discovered that experimental drugs called targeted activators of cell clearance (TACKs) can cause this enzyme to activate earlier while the virus is still inside the cell. When this happens, the CARD8 sensor detects the virus and triggers the infected cell to shut down through a natural cellular process before the virus can spread.

Early studies in people have shown promising results. In one study, these drugs reduced hidden HIV reservoirs by about 20–50% after four months of treatment. This is not a complete cure yet, but it shows that shrinking these hidden reservoirs may help control the virus in the future without lifelong medication. Researchers also believe reducing these reservoirs could lower long-term inflammation linked to health problems such as heart disease and some cancers. Scientists and pharmaceutical companies are now working to develop stronger versions of these drugs as part of ongoing efforts to eventually eliminate HIV.

[Shining Science @ShiningScience]

🚨 This triggers an internal immune sensor that destroys HIV from within.

For decades, the primary hurdle in curing HIV has been the virus’s ability to weave its genetic code into human cells and remain dormant, effectively hiding from both the immune system and standard medications. However, researchers have identified a way to exploit an internal immune sensor called CARD8. Normally, HIV evades this sensor by delaying the activation of its protease enzymes until it has already exited the host cell. New research shows that a class of drugs known as targeted activators of cell kill (TACK) can force these enzymes to activate prematurely while still inside. This “trips the alarm,” causing the infected cell to undergo pyroptosis—a form of programmed cell suicide—before it can release new copies of the virus into the bloodstream.

Early clinical evidence has already shown significant promise, with a recent study involving human participants demonstrating a 20% to 50% reduction in hidden viral reservoirs after just four months of treatment. While this is not yet a total cure, the proof-of-principle suggests that depleting these reservoirs could eventually lead to a "functional cure," allowing patients to control the virus without lifelong medication. Beyond a total cure, these TACK molecules could drastically improve long-term health by reducing the chronic inflammation linked to heart disease and cancer in survivors. Major pharmaceutical developers are now accelerating the testing of even more potent molecules, marking a pivotal shift in the global effort to finally eliminate the HIV epidemic.

Source: Cohen, J. (2026). New HIV cure approach forces hidden virus into tripping immune sensor. Science.

[Lollapalooza @lollapalooza]

Now we're all ONCE 🥲 @JYPETWICE

[dubu 🍫 seen Artms! @crushinondahyun]

EVERYBODY IS A ONCE !!! 🩷🧡🩷🧡

[This Is For TWICE again²⁰²⁶ @tzu___wice]

Same girl 😭 everyone is crying for twice

TWICE SEALS LOLLAPALOOZA #TWICE_AT_LOLLAPALOOZA #TWICEPALOOZA
@JYPETWICE

[AARON @lidolmix]

twice is really something else like you CAN’T speak on these girls

[👀 @ughhtwice]

I SAW JIHYO 👀

[steven 2.0 @nayeonationTTT]

Anyways

[Mingyu @mingyu0647]

Mingyu with his fanboy

[Wolf of X @WolfofX]

Proposals and Weddings

1. She didn't even look at the ring.. Bro won at life

[this is for twice fans mumbai @tozakivy]

thank god we didn't lose her to medical school 🙏🏼

[Pop Base @PopBase]

TWICE unveils the music video teaser to ‘Strategy’ ft. Megan Thee Stallion. Out this Friday.

[Pop Base @PopBase]

TWICE unveils the music video teaser to ‘Strategy’ ft. Megan Thee Stallion. Out December 6th.

[Pop Base @PopBase]

TWICE drops the album trailer to ‘STRATEGY.’

[chart data @chartdata]

#NAYEON is the best selling female K-Pop soloist by pure albums in the US this year so far.

[TWICE Charts @TWICE_Charts]

1 RETWEET/REPLY = 1 VOTE FOR TWICE!

THIS IS MY ONE VALID VOTE FOR DAY 3 #2024MAMAVOTE #TWICE

[julie @tzujuliee]

1 RETWEET = 1 VOTE FOR TWICE

RETWEET + REPLY

#2024MAMAVOTE #twice @JYPETWICE