ZPEWizard

Disclosure advocate. Physics fiend. Reality creator.

[ZPEWizard @ZPEWizard]

@bigpey Nature is healing

[ZPEWizard @ZPEWizard]

@zaidkdahhaj Aura blockers

[ZPEWizard @ZPEWizard]

@PragmaticNurse Guy thinks the sun beams out Vitamin D

[ZPEWizard @ZPEWizard]

@parapenjaga Every pose is the same and I'm tired of pretending any of them are better than the other

[ZPEWizard @ZPEWizard]

@fwmubi Is this magic?

[ZPEWizard @ZPEWizard]

Blueprint guaranteed to make you Healthy™.*

*This claim does not guarantee health.

[ZPEWizard @ZPEWizard]

@mscarnivore He'll end up pumping in more chemicals as immunotherapy before questioning his base assumptions

[ZPEWizard @ZPEWizard]

@Luizmd @bryan_johnson "Healthiest" is actually Healthy™ more medicines more healthy

[ZPEWizard @ZPEWizard]

@bryan_johnson What's your latest body temp reading? Does the immune system behave differently at different body temps?

[ZPEWizard @ZPEWizard]

@bryan_johnson Maybe we've gone overboard with the diagnosing?

[ZPEWizard @ZPEWizard]

@Sssebi Let em

[ZPEWizard @ZPEWizard]

@_The_Prophet__ "Corporate work became feminized HR theater for many personalities"

[ZPEWizard @ZPEWizard]

@UAPDr Imagine thinking you can disclose 80 years of secrets and also be able to stop an avalanche of follow up questions

[ZPEWizard @ZPEWizard]

@bigpey Spend 5 years in an industry to get scammed and crash out right before the main event. RIP

[ZPEWizard @ZPEWizard]

@DrJesseMorse Isn't it possible a molecule from a myriad of plants, pesticides, supplements etc is causing an immune cascade that shouldn't be happening?

[ZPEWizard @ZPEWizard]

@Mark_Sisson He should be rotating his main diet every 6ish months and seeing how all of his metrics change based on that.

[ZPEWizard @ZPEWizard]

@bryan_johnson @MikhailaFuller @theliondiet Aren't you the guy gathering the evidence? Also can you attempt to isolate which molecule(s) from plants, supplements etc might be involved in the autoimmune mechanism?

[ZPEWizard @ZPEWizard]

Don't eat babies or people tho. (Shouldn't have to be said but here we are)

[ZPEWizard @ZPEWizard]

Life begets life is still fundamentally true.

[William A. Wallace, Ph.D. @WilliamWallace]

Fermented foods lowered inflammation over 17 weeks. Adding more fiber did neither.

That's the finding from a Stanford randomized trial, and it should reframe how we think about feeding the gut.

Researchers assigned healthy adults to one of two microbiome-targeted diets, high-fiber or high-fermented-food, and ran deep immune and microbiome profiling across 17 weeks. The expectation going in was intuitive: fiber feeds your bacteria, so more of it should mean a healthier microbiome and lower inflammation.

That's not what happened.

The high-fiber group's inflammatory markers stayed flat. Its primary immune outcome, a composite cytokine response score, was unchanged from start to finish. And microbial diversity, one of the more reliable markers of gut resilience, held steady rather than rising.
The fermented-food group moved both. Inflammation declined steadily across the trial. Diversity climbed.

Fiber feeds bacteria the substrate they can digest. The study captured a signature of exactly this - i.e., the microbiome's glycan-degrading enzyme capacity rose while overall diversity stayed flat, consistent with the existing community upregulating rather than broadening

Fermented foods appear to do something structurally different. Live microbes plus the metabolic byproducts of fermentation seem to expand diversity directly, rather than by feeding what's already there. Greater diversity tracks with lower inflammatory load, and the fermented arm moved that lever while the fiber arm did not.
One detail worth sitting with: fiber wasn't inert for everyone. High-fiber consumers split into three distinct immune trajectories, and which one you landed in tracked your baseline microbiome diversity. Fiber's effect was contingent on the gut that received it. People starting with more diverse microbiomes likely respond differently than this average suggests.

Limitations:
Eighteen people per arm, healthy adults, 17 weeks. Inflammatory markers are intermediate biology, not clinical endpoints. Fiber's metabolic and cardiovascular benefits are established on separate, far larger evidence, and this trial doesn't touch them.

But for the specific job of moving the microbiome and inflammation, piling on more fiber wasn't the lever. The fermented foods, however, moved the needle.

Wastyk, Sonnenburg et al., Cell 2021.