Will The Wise

Public and private market investor. Just thoughts, not advice.

[Will The Wise @2ndStVentures]

🧬 Gene editing is steering us into a future where inherited diseases are optional, not inevitable.

Picture what’s ahead in the next 10–20 years:

✅ Sickle cell & beta thalassemia cured at scale, replacing transfusion wards with normal childhoods.

✅ In vivo gene editing tackling blindness, high cholesterol, and rare metabolic disorders. No hospital stays, just a one-time dose.

✅ Base-edited CAR-Ts evolving into frontline cancer weapons, wiping out solid tumors once thought untouchable

✅ Gene switches fine-tuned for longevity, repairing aging cells before disease ever appears.

✅ Once delivery hurdles fall, gene editing could rewrite the future of cystic fibrosis, muscular dystrophy, and even neurodegenerative giants like Alzheimer’s, turning lifelong disease management into one-time cures.

The boundary between “treatment” and “cure” is about to blur.

$CRSP $BEAM $NTLA $PRME

[Valar Atomics @valaratomics]

This Wednesday at 3PM ET, please join Valar Atomics and NVIDIA for a special livestream on the future of atomic energy and artificial intelligence.

[Will The Wise @2ndStVentures]

@IncomeSharks I own many of these but they also tend to do this at the top of a cycle lol. The future is bright, though,

[Dirk Haussecker @RNAiAnalyst]

John, as you are a Director of Beam Therapeutics and the former CEO of RNAi platform Co Alnylam, your view here surprises me.

I can e.g. remember Alnylam sending out seize and desist letters to competing, early-stage RNAi companies for violating Alnylam's fundamental IP. Similarly, Ionis sued and threatened to sue companies raising capital based on their IP. Well, in that case, you/Alnylam was a target.

Anyhow, this China is a flagrant violation of $beam exclusive IP and I, as a shareholder in Beam expect you, as a Director of Beam, to do something about it.

[Will The Wise @2ndStVentures]

@TheFlowHorse I love it personally as an investor in biotech but it looks a lot like 2021 top tbh. $XBI especially. Hopefully, this time is different.

[Valar Atomics @valaratomics]

Ward 250 has achieved the first step of power ascension and is currently standing at 10kW of thermal output, marking the first nuclear power generated by a startup.

[Prime Medicine @PrimeMedicine]

Milestone moment:

✅ New Zealand Clinical Trial Application cleared for PM577a
✅ First clinical authorization for our in vivo Prime Editing therapy
✅ Phase 1/2 trial in Wilson disease to begin

A step toward a potential one-time genetic cure. Data expected 2027.

[Will The Wise @2ndStVentures]

@3primeAnalytica @JessieChimni You mean sell $beam above $30 and buy below $26 on repeat forever 😂. One day that won't work, and it will be a beautiful day.

[Will The Wise @2ndStVentures]

@AAMortazavi @Biohazard3737 HAE alone should support much higher valuation…you get ATTR as a free call option imo

[Will The Wise @2ndStVentures]

@lBattleRhino What’s the secret sauce? Pls share

[Will The Wise @2ndStVentures]

Initially faded $ZEC as an end-of-cycle pump, but I now think there is a decent chance it could become a new store of value asset in coming years. The volume, tech, and attention are there. Governance drama may provide nice entries if markets don't die.

[Will The Wise @2ndStVentures]

@Merridew__ I mean I won’t say life changing but I very much enjoyed it. Big octopus guy. We don’t get a lot of octopus fiction really need to savor it.

[Will The Wise @2ndStVentures]

Why are my gene editing stocks acting like semiconductor stocks today $beam $prme $ntla

[Will The Wise @2ndStVentures]

@sama LNP delivery outside the liver for rare diseases

[Will The Wise @2ndStVentures]

@GeneInvesting He's currently calling management trash bc of price action and saying they should merge with BEAM. We are close.

[Will The Wise @2ndStVentures]

Very interested in owning $MP and $LEU at some point since they are borderline monopolies for rare earth and nuclear production in the US but need a lot more red first

[Will The Wise @2ndStVentures]

@crisprspace Let me know when you sell

[Will The Wise @2ndStVentures]

The fuckery continues for $NTLA. Not sure if going to 17 or 10 but vol is insane.

[Will The Wise @2ndStVentures]

Ummm what the fuck is going on in the $NTLA order books