🚨 Scientists have uncovered how deliberately training the mind to notice and savor positive experiences can fundamentally reshape neural architecture through neuroplasticity, the brain's remarkable ability to form new connections and reorganize itself in response to repeated activity.
Our brains naturally exhibit a negativity bias, an evolutionary remnant that prioritizes threats and unpleasant events for survival, causing positive moments to fade quickly while negative ones linger.
However, consistent practices like gratitude journaling or pausing to absorb good feelings counteract this by repeatedly activating reward and emotion-regulation circuits in regions such as the prefrontal cortex and anterior cingulate cortex.
Each time you focus on something uplifting—a kind interaction, a beautiful sunset, or personal accomplishment—neurons fire together, strengthening synaptic pathways associated with optimism and resilience.
Over weeks, this repeated activation thickens gray matter in areas tied to learning, memory, and emotional processing while diminishing the dominance of stress-related networks.
The result is a brain more attuned to positivity, reducing anxiety, enhancing emotional regulation, and fostering greater well-being even amid challenges.
Starting today requires only brief daily intention: notice the good, enrich the sensation by lingering on its details for ten to thirty seconds, and absorb it fully to convert fleeting experiences into lasting neural traits.
This accessible process empowers anyone to harness neuroplasticity for a more balanced, joyful mind.
Source: "The Neuroscience of Gratitude & Its Effects on the Brain," PositivePsychology. com (summarizing peer-reviewed fMRI studies including Zahn et al).
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And this is where I think there may be a huge opportunity.
Instead of continuing to measure only:
“How fatigued are you from 0 to 10?”
we could look for biologically defined fatigue phenotypes.
For example:
immune checkpoint inhibitor fatigue vs no fatigue
effector CD8 cells
IFN-γ
IL-2
IL-12
IL-6
metabolomics
glucose/lactate
brain ATP/PCr
dysautonomia
perfusion
objective activity
And then look for the same signature in:
- Long COVID
- ME/CFS
- post-EBV illness
- Sjögren’s
- lupus
- rheumatoid arthritis
- axial spondyloarthritis
- psoriatic arthritis
- inflammatory myopathies
- sarcoidosis
- multiple sclerosis
- primary biliary cholangitis
- IBD
Maybe there is no single “universal biomarker of fatigue.”
But there may be several objective subtypes of fatigue:
- immune-inflammatory
- neuroimmune
- autonomic
- vascular
- bioenergetic
- endocrine
- haematological
- neuromuscular
And then we could stop treating fatigue as a vague, nonspecific sensation and start asking:
what mechanism is producing fatigue in this patient?
That could completely change how we diagnose it, how we design trials and, ultimately, how we treat it.
I write these threads because I genuinely enjoy science communication, and because I hope this information can be useful to patients, researchers, clinicians or anyone trying to understand these diseases better.
If you found this thread useful, sharing it or leaving a like helps it reach more people.
And if there are other topics you would like me to write about in future threads, feel free to leave them in the comments.
You can also visit my profile for more threads on immunology, autoimmunity, Long COVID, ME/CFS, EBV, HLA, viral persistence and post-infectious disease.
I’m always happy to know what people find useful or want to understand better.
Thank you for reading.🩵
AI detectors are not always reliable.
For example, I tested some of my own publications from 2008-2012 using these detectors, and they all incorrectly predicted that 80-100% of the content was AI-written.
Technical writers will have a hard time navigating these AI detections.
A similar situation happened when photography was first invented. At first, traditional artists struggled to accept it, but over time, photography and painting found their own places as distinct art forms.
Similarly, as society becomes more familiar with AI, the fears and confusion will decrease, and a new normal will emerge.