Siamak Bahram

A Major Histocompatibility Complex (MHC)-centric view of life

[Siamak Bahram @6p21_3]

@exosome Yes, quite a few. Get in touch with me by email please.

[Siamak Bahram @6p21_3]

Thanks ERC for having funded our project, HISTOGENOMICS, aiming at identifying unknown non-HLA histocompatibility genes in man.

[European Research Council (ERC) @ERC_Research]

📣 Good news today for 255 outstanding research leaders who have been offered ERC Advanced Grants.

The new funding, worth nearly €652 million, is part of the 🇪🇺EU’s #HorizonEurope programme.

Read more 👉 https://t.co/HB95Po7e0o

#ERCAdG #FrontierResearch @EUScienceInnov

[Siamak Bahram @6p21_3]

Thank you @jhumimmunity for the highlight; congratulations to all involved and thanks to all our funding agencies.

[Journal of Human Immunity @jhumimmunity]

HYOU1 deficiency links ER #proteostasis failure to human #immunodeficiency. Idani, Carapito, @6p21_3 et al. identify defective B-cell development, persistent #neutrophil abnormalities, and #interferon pathway dysregulation as key disease mechanisms. https://t.co/DZq31mFoMB

[Siamak Bahram @6p21_3]

@UTSWMedCenter Bravo Jean-Laurent, UTSW is lucky to have you.

[Siamak Bahram @6p21_3]

@casanova_lab @AhmadYatim_ @vahidnezhadlab @LeilaYoussefian @JouanguyE @BeziatV @CancerResearch Dear @casanova_lab , glad to have been able to contribute to this highly interesting study, which again challenges some established dogmas. Congratulations to all, especially @AhmadYatim_

[Casanova Lab @casanova_lab]

18/ This calls for a complete re-evaluation of the textbook paradigm that LFA-1 is essential for neutrophil extravasation. The practice of referring to LAD-I as "LFA-1 deficiency" should also be reconsidered.

[Science Immunology @SciImmunology]

Deficiency in the leukocyte integrin #LFA1 increases susceptibility to commensal human papillomaviruses (#HPVs) by impairing T cell homing and surveillance in the skin. @AhmadYatim_ @casanova_lab @JouanguyE @vahidnezhadlab @BeziatV
https://t.co/C7xfMXKD7q

[Siamak Bahram @6p21_3]

Happy to report of my appointment (for a second term) as Senior Fellow of the Institut Universitaire de France (IUF). This will further help us to concentrate on our core research of identifying hitherto unknown histocompatibility genes in man. https://t.co/L7KsvXgQhN

[Aurore Perrot @PerrotAurore]

Thank you for publishing our study!

[Jacky GOETZ @GoetzJacky]

Check out our latest tiny foray in the world of gene mutations (ITPR3) related to #immunodeficiencies.
@KatkaJerabkova (post-doc) & @ignaciobusnelli (ex-EM expert) helped the team of S.Bahram showing how such mutation perturbs IP3R3 localization in patient fibroblasts.

[Inserm @Inserm]

Une équipe de recherche #Inserm a mis en évidence une mutation #génétique rare mais récurrente, à l’origine d’un trouble complexe, touchant plusieurs #organes et associé à une immunodéficience sévère.

Lire le communiqué : https://t.co/glfTNLHByk

[Siamak Bahram @6p21_3]

Just out ! Multiyear, multiteam effort from structural biology to clinical medicine |
A pleiotropic recurrent dominant ITPR3 variant causes a complex multisystemic disease | Science Advances https://t.co/GODF4WfAUR @Inserm @InsermEst @CHRUStrasbourg @ScienceAdvances

[CRBS @CRBS_Strasbourg]

👍Pr Seiamak Bahram @6p21_3 (directeur de l'unité 1109 @Inserm @InsermEst /Université de Strasbourg, chef de service du laboratoire d’immunologie @CHRUStrasbourg) remporte le prestigieux financement européen @ERC_Research Advanced Grant
➡️https://t.co/xTKrG3hv8z

[CHRU Strasbourg @CHRUStrasbourg]

Pr Bahram @6p21_3 lauréat du prestigieux financement @ERC_Research pour son projet qui vise à identifier la totalité des gènes d’histocompatibilité : une quête inachevée depuis près d’un siècle.

https://t.co/bIWxIl0O45

[Prof. Fafi-kremer Samira @FafiKremer]

Nous sommes fier(e)s de notre directeur de l'Unité Inserm UMR_1109, Pr Seiamak BAHRAM qui a été lauréat du prestigieux financement européen ERC Advanced Grant pour ses recherches sur la génétique et biologie des gènes d’histocompatibilité chez l’homme👏👏

[Siamak Bahram @6p21_3]

Journée nationale de réflexion sur le don d’organes et la greffe, le 22 juin 2023 - Salle de presse de l'Inserm https://t.co/NojaitCZNe

[Siamak Bahram @6p21_3]

A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumors: Med https://t.co/drI6ummyo1

[Siamak Bahram @6p21_3]

New vistas unfold: Chicken MHC molecules reveal unexpected ways to present peptides to the immune system https://t.co/hncRLMOpUm

[Society for Immune Polymorphism @immunomath]

“Strasbourg days in MHC Genetics” will be a new annual meeting in Strasbourg in Spring. Siemak discusses the Elephants in the room before the Elephants of Nantes #EFI2023

[EFI_Conference #EFI2026 @ConferenceEfi]

📣 PLENARY SPEAKER ANNOUNCEMENT!
Meet Prof. Seiamak Barham, our Plenary Speaker of the Session III.
The title of his lecture is " From HLA to MICA".
Reserve your seat at https://t.co/zYHORrwg7m
#HLA #immunogenetics #immunology #Nantes