Chronic Migraine: Preventive Treatment Options
(Note: The choice of drug depends on various factors, including age, gender, comorbid factors, pregnancy, availability and affordability. Treating doctor is the best judge to decide the best option for individual cases)
Reference: https://t.co/NeOXGBDi4S
#Medtwitter #Neurotwitter
ESCITALOPRAM: Rule of 3
1. 1x daily, morning/evening, with/without food. Milk OK. Works in 2–3 weeks, not instantly.
2. For long term anxiety, depression, panic & OCD maintenance.
3. Taper slowly. Sudden stop → brain zaps/dizziness. Avoid alcohol.
ALPRAZOLAM: Rule of 3
How Much does 1 unit of Insulin lower Glucose??
On an average, 1 unit of rapid-acting insulin lowers blood glucose by about 50 mg/dL (or roughly 2.5 to 3 mmol/L), but this varies widely.
Factors That change the Drop
• 𝗜𝗻𝘀𝘂𝗹𝗶𝗻 𝘀𝗲𝗻𝘀𝗶𝘁𝗶𝘃𝗶𝘁𝘆 : People who are very sensitive to insulin may see a drop of 75 mg/dL or more per unit, while people with 𝗜𝗻𝘀𝘂𝗹𝗶𝗻 𝗿𝗲𝘀𝗶𝘀𝘁𝗮𝗻𝗰𝗲 may only see a drop of 10 to 25 mg/dL per unit.
𝗧𝗼𝘁𝗮𝗹 𝗗𝗮𝗶𝗹𝘆 𝗗𝗼𝘀𝗲 (𝗧𝗗𝗗): Doctors often estimate your specific correction factor using formulas like the 𝟭𝟱𝟬𝟬 𝗼𝗿 𝟭𝟴𝟬𝟬 𝗿𝘂𝗹𝗲 (dividing 1500 or 1800 by your total daily units of insulin).
𝗔𝗰𝘁𝗶𝘃𝗶𝘁𝘆 𝗮𝗻𝗱 𝗦𝘁𝗿𝗲𝘀𝘀: Exercise, stress, illness, and hormones can change how your body responds to insulin.
⚠️Disclaimer: only for Education purposes
This doesn’t replace Professional medical advice or individualised insulin dosing.
#EndoTwitter #Obesity
Could some cases of migraine be on the same disease continuum as idiopathic intracranial hypertension? Interesting proposition! https://t.co/zBUPb8sl9T
"Diagnosis, Treatment, and Prognosis of Cerebral Venous Thrombosis" published in the journal Neurology (2026)
It visually breaks down the condition into distinct sections covering underlying mechanisms (such as thrombosis and inflammation), clinical phenotypes (like isolated headaches, seizures, and encephalopathy), radiologic findings on imaging scans, therapeutic pathways (including anticoagulation and surgical intervention), and long-term functional impacts.
https://t.co/0sjeS1zoNB
It’s not easy to find the perfect topic for a meta-analysis, but parainfectious (rather than postinfectious, as most patients still have fever at onset) neurological encephalopathic syndromes are a perfect one!
Great summary of this highly heterogeneous topic in @TheLancet !
Key messages:
• In adults, consider only ANE, FIRES, and MERS.
• Rotavirus is associated with MERS; influenza/SARS-CoV-2 with ANE, and HHV6 with AESD.
• High heterogeneity in MRI patterns and outcomes, with ANE having the worst outcomes despite treatment, suggesting that even umbrella term, they probably are different pathomechanims.
• And, of course, CSF helps rule out infection but, so far, does not aid much in diagnosis!
#Neurology #ITEM #Autoimmune
Key takeaways for coffee lovers:
✅Plain black or lightly sweetened coffee is best; avoid sugary syrups/additives.
▶️If you have advanced pre-existing kidney disease, monitor intake due to potassium content.
For most adults, your daily cup supports both organs- liver and kidneys!
3/3
Dr Sudhir Kumar @hyderabaddoctor
@SynapseDot Why? She could have helped so many kids…like my son w/ autism & seizures. Also, Train so many doctors along w/ AI. Intelligent ppl. r so fragile. Oh well.. (Drowning or autism is neither of our choices but we reflect/move along in life is in our hands.)
The FDA has approved tavapadon (JUVMO), a new once-daily dopamine D1/D5 receptor partial agonist for Parkinson’s disease that can be used as an initial symptomatic therapy or added to levodopa in people experiencing motor fluctuations, with the goal of improving good “ON” time. If you try tavapadon, remember that it is not automatically a replacement for your current Parkinson’s medications and that changes should be made with your treating clinician. Although clinical trials suggest that some of the problems traditionally associated with dopamine agonists may occur less frequently with this more selective drug, as tavapadon moves into real-world use we need to remain vigilant for the full spectrum of dopamine agonist related effects, including sleepiness, hallucinations, orthostatic hypotension, dyskinesia, and impulse-control behaviors (shopping, gambling, hypersexuality, others). New mechanism and once-a-day dosing are exciting, but careful monitoring after approval will tell us how tavapadon performs in the broader Parkinson’s community.
A middle-aged female presents to the EMG lab with chronic, progressive neuropathy symptoms. The symptoms are classic, the exam is striking, and the EMG showed a unique pattern. Can you solve the case?