Agnes Noy

Agnes Noy research account: Senior Lecturer at the University of York. DNA, biophysics, modelling, supercoiling, and much more. Active in @agnesnoy.bsky.social

[Agnes Noy @ANoyLab]

Come to York and fight antimicrobial resistance with Daniel Cole, @dghilarov and Inspiralis Ltd.
MRC DiMeN Doctoral Training Partnership: Computational Drug Discovery Targeting DNA Gyrase to Tackle Antimicrobial Resistance at University of York on https://t.co/tTCCSf6HjA

[Steve Quinn @Steve_Quinn_Lab]

Congrats to @JamiesonH - our latest @PhysLifeYork work dissecting the structural landscape of the Rep Helicase is now in Nucleic Acids Research! Huge team effort! @Craggs_Lab @AllisonHSquires @ANoyLab @BPSIYork @mahmoud @DrM_Abdelhamid @Single_Mole
👇
https://t.co/6bhd3mRmDf

[Agnes Noy @ANoyLab]

Overall, HU binds DNA in a multi-step process: electrostatic interactions build up gradually until the protein locks onto its target site. This prevents HU from sticking to random DNA along the way.

[Agnes Noy @ANoyLab]

Check our latest publication in #JACSAu @ACSPublications with @ElliotWChan and @BPSIYork where we describe how the bacterial protein HU binds DNA at atomic resolution. Thanks to @EPSRC and @N8CIR and @hecbiosim for computational resources. See more👇https://t.co/OWgl9rJpK7

[Agnes Noy @ANoyLab]

The switch to high-affinity HU–DNA binding happens only at the target site, helped by DNA’s own flexibility. It suggests a concerted mechanism, bridging the gap between “induced fit” and “conformational selection.”

[Kunal Rai @krai171009]

Gave my first talk at the @UniOfYork Grateful to @BPSIYork & @ANoyLab for the opportunity, and to my supervisor @joshiphy for his constant support. It was a truly enriching experience to share my work and interact with such inspiring researchers. Also thnks to @SonamRagha77827

[MDDB @mddbEU]

📢 Our article calling for a #FAIR database for #MolecularDynamics simulation data has now been peer-reviewed and published in @naturemethods

📖 Read it here: https://t.co/2VXy3pgepZ

📝 Support the statement: https://t.co/7vp58TPy1A

#MDDB #FAIRdata #collaboration

[Agnes Noy @ANoyLab]

Looking forward to attending this meeting and having interesting discussions about ai vs physics-based modelling approaches 🙂

[Potestio Lab @r_potestio]

Biophysics, Stat Mech and Machine Learning will meet in Trento from July 7th to 11th, 2025 in our StatPhys29 Satellite Workshop "Molecular biophysics at the transition state: from statistical mechanics to AI": https://t.co/B6P1HW2YrY.

Co-organized with @ai_ngrosso.

[Andrew Goryachev 🇺🇦 @GoryachevAndrew]

🚨🚨Please RT! 📢📢
Still time to submit short talk abstract for EdinPBS2025!
Five themes this year:
· Mechanobiology
· Protein pattern formation
· 4D Genome
· Stochastic biology
· Biohydrodynamics
https://t.co/rIeodmzBHQ

[Agnes Noy @ANoyLab]

This is one of the conferences where I have genuinely learned more. Delighted to contribute to this vision article.

[Mahipal Ganji @mahipal_ganji]

An article talking about ‘Future directions of the prokaryotic chromosome field’. This vision article resulted from of a workshop organized at @lorentzcenter

https://t.co/HsTz3uapWA

[University of York @UniOfYork]

Fundamental research into DNA “bubbles” will improve scientists' understanding of how genetic programs unfold to help in disease detection and treatment @ANoyLab https://t.co/aZWanzttPl

[Agnes Noy @ANoyLab]

Were you interested in our last paper in @PhysRevLet but found it too complex to follow? Then look at this article by @physorg_com, where it is explained in plain terms
https://t.co/XIR6eQ9CGv

[Agnes Noy @ANoyLab]

Thrilled that the paper has just appeared in @PhysRevLett. Excellent work from Matt Burman's @EPSRC -funded PhD. Thanks to @N8CIR and @hecbiosim for computational resources. Check the updated thread in @agnesnoy.bsky.social!
https://t.co/mqxtR94Cyk

[Agnes Noy @ANoyLab]

📢 Preprint alert: How the structure of linear DNA is distorted by physiological levels of torsion and tension? 🧬🧬 The answer by all-atom simulations and it is similar from what we saw on minicircles with @alicepyne 👇(1/n) https://t.co/xBs2rImX24

[Mahipal Ganji @mahipal_ganji]

Having attended the previous edition, I can vouch for how insightful this conference is. Don’t miss the chance to be part of this vibrant community!

[Agnes Noy @ANoyLab]

Nearly 50% of researchers quit science within a decade, huge study reveals. women are more likely than men to leave research. https://t.co/1qy69ymIG3

[David K Smith @professor_dave]

So she was first author on his key paper - in fact she's on most of his key papers, yet she didn't get the Nobel Prize, in spite of the fact they could have given 3 awards, not just 2. Explain to me how STEM is not institutionally sexist.

[Agnes Noy @ANoyLab]

We visited Tony Maxwell in Norwich last week, and he kindly accommodated us at his home. He mailed the socks I forgot back to me… 😂

[Physics of Life @PhysicsofLifeUK]

A fantastic outcome from @PhysicsofLifeUK summer studentship funding, congratulations @TaniaGardasevic and @ANoyLab on this lovely 🧬paper.