Let’s review epithelial-myoepithelial lesions of the breast this week! 🦑
Collagenous Spherulosis 🔬
Well-circumscribed intraluminal spherules of basement membrane-like material surrounded by a dual epithelial-myoepithelial cell population.
#PathX#PathTwitter#breastpath
Second look! 🧐
Exaggerated intracanalicular growth pattern with leaf-like stromal fronds and hypercellular stroma.
Which molecular alteration is characteristic?
A) MED12 and TERT promoter mutations
B) CTNNB1 (beta-catenin) mutation
C) MYC amplification
D) ETV6::NTRK3 fusion
A 62-year-old woman presents with a polypoid intrauterine mass.
Aggressive cases of this tumor demonstrate:
A) JAZF1::SUZ12 fusion
B) FOXL2 mutation
C) DICER1 mutation
D) MYBL1 amplification
#PathQuiz 🔬🧬
#Pathology#GYNPath#MolecularPath
Clue in caption 🧐
Excited to share our latest work published in @IJGynP!
PRAME IHC is highly sensitive and specific for distinguishing endometrial from endocervical adenocarcinomas, with strong concordance to mRNA expression. A practical adjunct in challenging cases and tumors of uncertain primary. #GynPathology
Link 👉🏻 https://t.co/u6m28m0KLF
Spindled lesions in the breast? No longer feared after this collaborative session between breast pathologist Dr. Atkins and soft tissue pathologist Dr. Fanburg-Smith!
Full house at the Pulmonary Pathology Society lecture by Dr. Jennifer Boland
Genomically Defined Carcinoma of The Lungs discussing the features of Thoracic SMARCA4- deficient undifferentiated and NUT carcinoma of the Thorax @TheUSCAP@JenniferBoland7
Our poster about ERBB2 driven malignant adnexal tumors triggered a lot of interesting and insightful discussions! Thanks for all who came by to talk with me about it! #USCAP#pathology#USCAP2026#dermatopathology