Ahmed Ismail, MD

IM PGY-2 @EVMSedu @ODU | Former Research Fellow @ONealCancerUAB & @NUFeinbergMed 🇺🇸 | MD @CairoUniv 🇪🇬

[Ahmed Ismail, MD @A_Ismail_MD]

I am happy to share our most recent study, published in @Cancers_MDPI, which evaluates the significance of baseline lymphopenia among ICI-naive patients with solid tumors receiving ICI.

Many thanks to my great professors for their mentorship and support! @YanisBoumberMD, @NinaOncMD, and @GRSimonMD.

🔗 https://t.co/7imi9fzxXc

📊 Results:
Among 10,498 propensity-score-matched patients, baseline lymphopenia was associated with:
• Worse OS at 6 months (HR 1.29), 12 months (HR 1.28), and 24 months (HR 1.26).
• Higher early healthcare utilization (HR 1.12).
• Higher serious infection risk (HR 1.11).
• Interestingly, similar clinically coded irAE risk (HR 1.0).
• The association remained evident even after stratification by major tumor types and prior lines of therapy.

💡 Takeaways:
• Baseline ALC may be a simple, widely available biomarker for risk stratification before the start of ICI, helping identify patients at higher risk of poor outcomes.
• Can targeted lymphocyte reconstitution before or alongside ICI initiation improve outcomes?

@EVMSMedicine @EVMSedu
#HemeOnc

[Ahmed Ismail, MD @A_Ismail_MD]

@Dan_Batlle @Biomol_MDPI @ADesaiMD @YBoumber @EVMSMedicine Thank you, Dr. Batlle! 🙏😁

[Ahmed Ismail, MD @A_Ismail_MD]

I am happy to share that our review article on Non-HER2 ADCs in NSCLC has been accepted in @Biomol_MDPI.

Thank you, @ADesaiMD, and @YBoumber, for your continued mentorship and guidance!
https://t.co/UE4P6W2FOK

#HemeOnc @EVMSMedicine

[EVMS Medicine @EVMSMedicine]

Proud of our residents & med students presenting at national & local conferences!
Advancing knowledge. Inspiring innovation. Shaping the future of medicine.
#MedEd #Research #FutureOfMedicine @EVMSedu

[Ahmed Ismail, MD @A_Ismail_MD]

@badawyy111 Badaaaaawy! Thank you very much!

[Ahmed Ismail, MD @A_Ismail_MD]

@badawyy111 Thank you, Badawy!🩷

[Ahmed Ismail, MD @A_Ismail_MD]

I had the pleasure of presenting my work at the AACR Annual Meeting 2026 and connecting with colleagues interested in hematology/oncology.
Grateful for the opportunity to share my research and learn from leaders across the field.

[Ahmed Ismail, MD @A_Ismail_MD]

@Blabla_ologist حبيبي يا ياسر ❤️ بعض ما عندكم 😬❤️

[Ahmed Ismail, MD @A_Ismail_MD]

@Dan_Batlle @ardemp @CellCellPress @NUFeinbergMed @NU_Nephrology Congratulations, Dr. Batlle! Happy Holidays! 🎉

[Ahmed Ismail, MD @A_Ismail_MD]

@badawyy111 @svinsociety Ya Badaaaawy! Congrats, bro! ❤️

[Ahmed Ismail, MD @A_Ismail_MD]

@badawyy111 @OncJournal @ADesaiMD @Jani_Chinmay ❤️❤️

[Ahmed Ismail, MD @A_Ismail_MD]

I am happy to share that our paper on evaluating HER2 in solid tumors has been accepted in @OncJournal.

Thank you @ADesaiMD @Jani_Chinmay for your mentorship and guidance!

[Chinmay Jani @Jani_Chinmay]

Check out our recent analysis @OncJournal under mentorship of @ADesaiMD of 653 solid tumors evaluating HER2 by IHC, CNV & mutational profiling.
📊 Results:
•IHC+: 3+ (3.1%), 2+ (13.2%), 1+ (19.8%), 63.9% neg
•CN amplification: 3.1% (75% IHC3+)
•Pathogenic ERBB2 mutations: 3.1% (only 5% IHC3+)
🔑 ERBB2-mut tumors rarely show IHC3+/CN amp → highlights need for comprehensive genomic testing.
💡 In the era of pan-tumor T-DXd approval, integrating genomic + phenotypic data can refine patient selection & advance precision oncology.
@ONealCancerUAB @MehmetAkce2 @YanisBoumberMD @BasselElRayesMD
@SylvesterCancer
@HemOncMiami @carisls

[Mario Balsa @MarioBalsaMD]

📢 New in @FrontOncology by @ADesaiMD, @A_Ismail_MD & @YanisBoumberMD:
HER2-altered #NSCLC: from🔬 to therapeutics 🎯

https://t.co/SdPAPqVBhR

🤝 Love it!! But…can HER2 keep dancing when resistance cuts the music? 🎹

#OncoAlertAF @On@OncoAlert @_SEOM @gecp_org @Lung_Cancers @LungCancerRx

[Ahmed Ismail, MD @A_Ismail_MD]

@azzaakhaled95 شكرًا يا عزة 🙏

[Ahmed Ismail, MD @A_Ismail_MD]

A new chapter begins: Day 1 of orientation at @EVMSMedicine ✅ Grateful and excited for the journey ahead.

[Khaled Ali, MD @KhaledAliMD]

Hi,
I am applying for cardiology
I need prayers
Bye
#Cardiology
#cardiotwitter
#match26
@TheNRMP

[Ahmed Ismail, MD @A_Ismail_MD]

@Muhammadarnous Thank you ya Arnous! ❤️

[Ahmed Ismail, MD @A_Ismail_MD]

@shadyazzam1 Thanks, Shady!
Of course, I DMed you. 🙏

[Ahmed Ismail, MD @A_Ismail_MD]

@Essam_Ibrahim94 Thank you, Essam ❤️

[Ahmed Ismail, MD @A_Ismail_MD]

@Karim_ALarby @EVMSMedicine Thank you ya Kimo ❤️

[Ahmed Ismail, MD @A_Ismail_MD]

@Dan_Batlle Thank you very much, Dr. Batlle! 🙏🌟