Afshine Emrani MD FACC

Cardiologist. Author.
Jew. ✡️ Zionist. 🇮🇱🇺🇸
Kaballah. Rumi.
Japanese antiques.
#BTC
Insta: @afshineemrani
web:

[Afshine Emrani MD FACC @afshineemrani]

@Polymarket CITADEL shorted during his wedding?
EVIL.

[Mosab Hassan Yousef @MosabHasanYOSEF]

Gaza is the land of Israel. Palestinians should return to their countries of origin, Egypt, Jordan, or Syria.

[Hampton Howell, dialogue & non-violence. @citizenpsych]

New Review Challenges High-Protein Diets for Healthy Aging

Researchers . Knopf & Lamming from the University of Wisconsin-Madison published findings in Cell Press Blue showing that protein restriction improves nutrient sensing, metabolic health, mitochondrial function, and reduces cellular senescence across species....

[Afshine Emrani MD FACC @afshineemrani]

@DavidMKeyes Here you go... https://t.co/2sfix9J348

[Forbidden HQ 🐇 @WearForbidden]

If we're being honest about what's going on in Spain:

[Afshine Emrani MD FACC @afshineemrani]

@jaredkushner some people still don't believe this...

https://t.co/TjIY1GpEEj

[John Spencer @SpencerGuard]

Hamas accepts — publicly and explicitly — a framework that includes full demilitarization and de-radicalization.!!!

[Afshine Emrani MD FACC @afshineemrani]

@jaredkushner BRAVO!

[Afshine Emrani MD FACC @afshineemrani]

@elonmusk @GadSaad When I visited Europe, no other country had as many "FREE PALESTINE" flags and graffiti as Spain. Make Spain Gaza Again...! You got rid of your Jews for Islamists. Good luck to your women.

[Afshine Emrani MD FACC @afshineemrani]

@howardlutnick @allison_lutnick Amazing! MAZAL TOV. Wow.

[S Sebag Montefiore @simonmontefiore]

The song of Boy George is moving even beautiful and it is a peace song an anti war song. There is a cost to be paid for speaking freely even in a free country like ours but it is worth the stress and strife to advance the truth.
Yet on this day of hopeful positive developments in Gaza and possible Hamas disarmament, @BoyGeorge has faced a mob of those who have tried to use purity tests, threats of peril and cancellation, and poisonous names to stop him and others speaking freely about the war & its ferocity, the sufferingof Israelis at Nova & in the Oct7 killing spree and the heartbreaking death and suffering of Palestinian civilians in the subsequent brutal Israel vs Hamas war.

It is ironic that he has apparently been forced to retire fr Jesus Christ Superstar a rather Jewish story in which he played a Judean prince Herod Antipas.

Anyway this was his admirable answer:

‘The suggestion that I feel no compassion for Palestinians is both untrue and absurd. I am devastated for the loss of the innocent lives on both sides of this war and I call for peace.

I have read members of the press calling me a ‘genocide denier’ yet those who deny the suffering of Israelis are given a free pass.

My song is pro peace and about the emotions I felt after visiting the Nova Exhibition and talking to Michael and Lisa Marlowe who had their son Jake taken from them. Murdered trying help others.

Everyone knows what happened to innocent women, kids, babies, sons and fathers on that day, innocent people who were at a festival celebrating life.
The Nova Festival is a mirror of my world as a DJ and I have played many such festivals, including in Israel so it resonated with me and I felt compelled to write something. I could have been there and we know that there were people from more than 40 countries who were. I felt these deep emotions and is wrote this song for them.

My personal opinion is that this is sadly a war , but not an attempt to wipe out Palestine. ‘

[Afshine Emrani MD FACC @afshineemrani]

GOD WILL BLESS YOU @BoyGeorge
more and more each day
YOU ARE LOVED

[Boy George @BoyGeorge]

It doesn't matter what I think or what you think. When will you realise you're doing NOTHING! It's a fucking joke. I am even falling out with Jewish friends. The madness knows no bounds.

[Afshine Emrani MD FACC @afshineemrani]

In a world where standing up for what's right often comes at a steep price, @BoyGeorge chose courage over comfort.

Despite the noise, threats, and backlash following his powerful song in support of the Jewish community, his willingness to speak out when so many remain silent speaks volumes. True art has always been about bravery, empathy, and standing with people when it matters most—not just when it’s easy.

To @BoyGeorge: The chaos and hostility do not define this moment—your moral clarity does. Thank you for using your voice, your platform, and your heart to stand against hate. You are deeply appreciated, respected, and supported by so many during this time. 💛✨

#BoyGeorge #StandUpToHate #Courage #Gratitude

[Afshine Emrani MD FACC @afshineemrani]

In a world where standing up for what's right often comes at a steep price, @BoyGeorge chose courage over comfort.

Despite the noise, threats, and backlash following his powerful song in support of the Jewish community, his willingness to speak out when so many remain silent speaks volumes. True art has always been about bravery, empathy, and standing with people when it matters most—not just when it’s easy.

To @BoyGeorge: The chaos and hostility do not define this moment—your moral clarity does. Thank you for using your voice, your platform, and your heart to stand against hate. You are deeply appreciated, respected, and supported by so many during this time. 💛✨

#BoyGeorge #StandUpToHate #Courage #Gratitude

[Afshine Emrani MD FACC @afshineemrani]

In a world where standing up for what's right often comes at a steep price, @BoyGeorge chose courage over comfort.

Despite the noise, threats, and backlash following his powerful song in support of the Jewish community, his willingness to speak out when so many remain silent speaks volumes. True art has always been about bravery, empathy, and standing with people when it matters most—not just when it’s easy.

To @BoyGeorge: The chaos and hostility do not define this moment—your moral clarity does. Thank you for using your voice, your platform, and your heart to stand against hate. You are deeply appreciated, respected, and supported by so many during this time. 💛✨

#BoyGeorge #StandUpToHate #Courage #Gratitude

[Afshine Emrani MD FACC @afshineemrani]

In a world where standing up for what's right often comes at a steep price, @BoyGeorge chose courage over comfort.

Despite the noise, threats, and backlash following his powerful song in support of the Jewish community, his willingness to speak out when so many remain silent speaks volumes. True art has always been about bravery, empathy, and standing with people when it matters most—not just when it’s easy.

To @BoyGeorge: The chaos and hostility do not define this moment—your moral clarity does. Thank you for using your voice, your platform, and your heart to stand against hate. You are deeply appreciated, respected, and supported by so many during this time. 💛✨

#BoyGeorge #StandUpToHate #Courage #Gratitude

[Afshine Emrani MD FACC @afshineemrani]

@KenDBerryMD https://t.co/OEHJ01t7vd

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. A review published this morning just took a sledgehammer to the protein-maxxing era. And the most important detail isn't in the headline — it's buried in the human data. Lamming's lab at Wisconsin reviewed over 350 studies on protein restriction and aging, published today in Cell Press Blue. As @EricTopol put it, they define — for the first time — the hallmarks of protein restriction:

Improved metabolic health. Induction of nutrient-sensing pathways. Decreased senescence. Improved mitochondrial function. An altered epigenome. And the promotion of healthy aging.

Six hallmarks. From eating less protein, while still meeting your needs.

𝗧𝗵𝗲 𝗻𝘂𝗺𝗯𝗲𝗿𝘀 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗺𝗼𝗱𝗲𝗹𝘀

Flies: up to 122% longer life. Rodents: 10-50%+ gains. Methionine restriction alone: 7-42% lifespan extension. Cutting isoleucine and valine: 23-65% in various setups — with less frailty and less cancer.

𝗧𝗵𝗲 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺 𝘀𝗵𝗼𝘂𝗹𝗱 𝘀𝗼𝘂𝗻𝗱 𝗳𝗮𝗺𝗶𝗹𝗶𝗮𝗿

Excess protein — especially leucine, isoleucine, valine, and methionine — keeps mTOR switched on. mTOR is the growth accelerator. Keep it humming and autophagy shuts down, cells stop cleaning house, and senescent "zombie" cells accumulate.

Restrict protein and it reverses. mTOR quiets. GCN2 activates autophagy. And FGF21 surges — driving fat burning, insulin sensitivity, and lower inflammation.

This is the exact pathway rapamycin targets. The exact pathway fasting targets. We've been chasing it with drugs while telling everyone to eat more of the thing that blocks it.

𝗧𝗵𝗲 𝗵𝘂𝗺𝗮𝗻 𝗱𝗮𝘁𝗮 — 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗳𝗶𝗻𝗱𝗶𝗻𝗴 𝘁𝗵𝗮𝘁 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝗲𝘃𝗲𝗿𝘆𝘁𝗵𝗶𝗻𝗴

Levine's landmark Cell Metabolism study followed adults for 18 years. Those aged 50-65 with high protein intake had a 75% increase in overall mortality and a four-fold increase in cancer death.

But here's the line nobody quotes: those associations were abolished or attenuated when the protein was plant-derived.

Same amount of protein. Different source. Different outcome.

And the age flip matters enormously: over 65, high protein was associated with reduced mortality. Your protein needs change with age — in the opposite direction from what the influencers say.

𝗧𝗵𝗲 𝗵𝗼𝗻𝗲𝘀𝘁 𝗰𝗮𝘃𝗲𝗮𝘁𝘀

Topol's own caution is right: this review rests largely on model organisms. So does most of the healthspan literature, including rapamycin — but "true in mice" isn't "true in humans," and I won't pretend otherwise.

And Lamming himself gave the nuance that saves this from being clickbait: athletes consume enormous protein without developing metabolic disease. He suspects exercise protects them — the protein goes into building muscle instead of idling in growth pathways.

So the finding isn't "protein is bad." It's that protein without exercise may be the problem. A sedentary person drinking protein shakes, eating protein cereal and protein water is chronically flooring a growth pathway with nothing demanding growth.

𝗪𝗵𝗲𝗿𝗲 𝗜 𝗹𝗮𝗻𝗱, 𝗮𝘀 𝗮 𝗰𝗮𝗿𝗱𝗶𝗼𝗹𝗼𝗴𝗶𝘀𝘁

If you're sedentary and eating 1.5-2g/kg because an influencer told you to — the data doesn't support it, and it may be working against you.

If you lift hard 3-4x a week, that protein has somewhere to go. Different equation.

And if you're over 70 or frail — do not cut your protein. Sarcopenia will kill you faster than mTOR will. Older adults and pregnant women need more, and the authors say so explicitly.

I still believe the Mediterranean diet is the best diet on earth, and this review is the mechanistic explanation of why.

It delivers moderate protein — mostly plants, legumes, nuts, fish. Lower methionine density. Olive oil, fiber, polyphenols. It hits every lever this paper describes without a single scoop of powder.

Lamming's own lab tested it: a low-protein diet modeling the traditional Mediterranean and Okinawan patterns, head-to-head against Western and ketogenic diets. Western and keto increased fat mass and frailty. The Mediterranean-style diet reduced both and improved cardiometabolic markers.

Traditional Okinawa ran about 9% of calories from protein.

The blue zones didn't drink protein shakes.

They ate beans, and they moved every single day.

[Afshine Emrani MD FACC @afshineemrani]

@BiggestComeback https://t.co/OEHJ01t7vd

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. A review published this morning just took a sledgehammer to the protein-maxxing era. And the most important detail isn't in the headline — it's buried in the human data. Lamming's lab at Wisconsin reviewed over 350 studies on protein restriction and aging, published today in Cell Press Blue. As @EricTopol put it, they define — for the first time — the hallmarks of protein restriction:

Improved metabolic health. Induction of nutrient-sensing pathways. Decreased senescence. Improved mitochondrial function. An altered epigenome. And the promotion of healthy aging.

Six hallmarks. From eating less protein, while still meeting your needs.

𝗧𝗵𝗲 𝗻𝘂𝗺𝗯𝗲𝗿𝘀 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗺𝗼𝗱𝗲𝗹𝘀

Flies: up to 122% longer life. Rodents: 10-50%+ gains. Methionine restriction alone: 7-42% lifespan extension. Cutting isoleucine and valine: 23-65% in various setups — with less frailty and less cancer.

𝗧𝗵𝗲 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺 𝘀𝗵𝗼𝘂𝗹𝗱 𝘀𝗼𝘂𝗻𝗱 𝗳𝗮𝗺𝗶𝗹𝗶𝗮𝗿

Excess protein — especially leucine, isoleucine, valine, and methionine — keeps mTOR switched on. mTOR is the growth accelerator. Keep it humming and autophagy shuts down, cells stop cleaning house, and senescent "zombie" cells accumulate.

Restrict protein and it reverses. mTOR quiets. GCN2 activates autophagy. And FGF21 surges — driving fat burning, insulin sensitivity, and lower inflammation.

This is the exact pathway rapamycin targets. The exact pathway fasting targets. We've been chasing it with drugs while telling everyone to eat more of the thing that blocks it.

𝗧𝗵𝗲 𝗵𝘂𝗺𝗮𝗻 𝗱𝗮𝘁𝗮 — 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗳𝗶𝗻𝗱𝗶𝗻𝗴 𝘁𝗵𝗮𝘁 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝗲𝘃𝗲𝗿𝘆𝘁𝗵𝗶𝗻𝗴

Levine's landmark Cell Metabolism study followed adults for 18 years. Those aged 50-65 with high protein intake had a 75% increase in overall mortality and a four-fold increase in cancer death.

But here's the line nobody quotes: those associations were abolished or attenuated when the protein was plant-derived.

Same amount of protein. Different source. Different outcome.

And the age flip matters enormously: over 65, high protein was associated with reduced mortality. Your protein needs change with age — in the opposite direction from what the influencers say.

𝗧𝗵𝗲 𝗵𝗼𝗻𝗲𝘀𝘁 𝗰𝗮𝘃𝗲𝗮𝘁𝘀

Topol's own caution is right: this review rests largely on model organisms. So does most of the healthspan literature, including rapamycin — but "true in mice" isn't "true in humans," and I won't pretend otherwise.

And Lamming himself gave the nuance that saves this from being clickbait: athletes consume enormous protein without developing metabolic disease. He suspects exercise protects them — the protein goes into building muscle instead of idling in growth pathways.

So the finding isn't "protein is bad." It's that protein without exercise may be the problem. A sedentary person drinking protein shakes, eating protein cereal and protein water is chronically flooring a growth pathway with nothing demanding growth.

𝗪𝗵𝗲𝗿𝗲 𝗜 𝗹𝗮𝗻𝗱, 𝗮𝘀 𝗮 𝗰𝗮𝗿𝗱𝗶𝗼𝗹𝗼𝗴𝗶𝘀𝘁

If you're sedentary and eating 1.5-2g/kg because an influencer told you to — the data doesn't support it, and it may be working against you.

If you lift hard 3-4x a week, that protein has somewhere to go. Different equation.

And if you're over 70 or frail — do not cut your protein. Sarcopenia will kill you faster than mTOR will. Older adults and pregnant women need more, and the authors say so explicitly.

I still believe the Mediterranean diet is the best diet on earth, and this review is the mechanistic explanation of why.

It delivers moderate protein — mostly plants, legumes, nuts, fish. Lower methionine density. Olive oil, fiber, polyphenols. It hits every lever this paper describes without a single scoop of powder.

Lamming's own lab tested it: a low-protein diet modeling the traditional Mediterranean and Okinawan patterns, head-to-head against Western and ketogenic diets. Western and keto increased fat mass and frailty. The Mediterranean-style diet reduced both and improved cardiometabolic markers.

Traditional Okinawa ran about 9% of calories from protein.

The blue zones didn't drink protein shakes.

They ate beans, and they moved every single day.

[Afshine Emrani MD FACC @afshineemrani]

@Mangan150 @sweatystartup https://t.co/OEHJ01t7vd

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. A review published this morning just took a sledgehammer to the protein-maxxing era. And the most important detail isn't in the headline — it's buried in the human data. Lamming's lab at Wisconsin reviewed over 350 studies on protein restriction and aging, published today in Cell Press Blue. As @EricTopol put it, they define — for the first time — the hallmarks of protein restriction:

Improved metabolic health. Induction of nutrient-sensing pathways. Decreased senescence. Improved mitochondrial function. An altered epigenome. And the promotion of healthy aging.

Six hallmarks. From eating less protein, while still meeting your needs.

𝗧𝗵𝗲 𝗻𝘂𝗺𝗯𝗲𝗿𝘀 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗺𝗼𝗱𝗲𝗹𝘀

Flies: up to 122% longer life. Rodents: 10-50%+ gains. Methionine restriction alone: 7-42% lifespan extension. Cutting isoleucine and valine: 23-65% in various setups — with less frailty and less cancer.

𝗧𝗵𝗲 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺 𝘀𝗵𝗼𝘂𝗹𝗱 𝘀𝗼𝘂𝗻𝗱 𝗳𝗮𝗺𝗶𝗹𝗶𝗮𝗿

Excess protein — especially leucine, isoleucine, valine, and methionine — keeps mTOR switched on. mTOR is the growth accelerator. Keep it humming and autophagy shuts down, cells stop cleaning house, and senescent "zombie" cells accumulate.

Restrict protein and it reverses. mTOR quiets. GCN2 activates autophagy. And FGF21 surges — driving fat burning, insulin sensitivity, and lower inflammation.

This is the exact pathway rapamycin targets. The exact pathway fasting targets. We've been chasing it with drugs while telling everyone to eat more of the thing that blocks it.

𝗧𝗵𝗲 𝗵𝘂𝗺𝗮𝗻 𝗱𝗮𝘁𝗮 — 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗳𝗶𝗻𝗱𝗶𝗻𝗴 𝘁𝗵𝗮𝘁 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝗲𝘃𝗲𝗿𝘆𝘁𝗵𝗶𝗻𝗴

Levine's landmark Cell Metabolism study followed adults for 18 years. Those aged 50-65 with high protein intake had a 75% increase in overall mortality and a four-fold increase in cancer death.

But here's the line nobody quotes: those associations were abolished or attenuated when the protein was plant-derived.

Same amount of protein. Different source. Different outcome.

And the age flip matters enormously: over 65, high protein was associated with reduced mortality. Your protein needs change with age — in the opposite direction from what the influencers say.

𝗧𝗵𝗲 𝗵𝗼𝗻𝗲𝘀𝘁 𝗰𝗮𝘃𝗲𝗮𝘁𝘀

Topol's own caution is right: this review rests largely on model organisms. So does most of the healthspan literature, including rapamycin — but "true in mice" isn't "true in humans," and I won't pretend otherwise.

And Lamming himself gave the nuance that saves this from being clickbait: athletes consume enormous protein without developing metabolic disease. He suspects exercise protects them — the protein goes into building muscle instead of idling in growth pathways.

So the finding isn't "protein is bad." It's that protein without exercise may be the problem. A sedentary person drinking protein shakes, eating protein cereal and protein water is chronically flooring a growth pathway with nothing demanding growth.

𝗪𝗵𝗲𝗿𝗲 𝗜 𝗹𝗮𝗻𝗱, 𝗮𝘀 𝗮 𝗰𝗮𝗿𝗱𝗶𝗼𝗹𝗼𝗴𝗶𝘀𝘁

If you're sedentary and eating 1.5-2g/kg because an influencer told you to — the data doesn't support it, and it may be working against you.

If you lift hard 3-4x a week, that protein has somewhere to go. Different equation.

And if you're over 70 or frail — do not cut your protein. Sarcopenia will kill you faster than mTOR will. Older adults and pregnant women need more, and the authors say so explicitly.

I still believe the Mediterranean diet is the best diet on earth, and this review is the mechanistic explanation of why.

It delivers moderate protein — mostly plants, legumes, nuts, fish. Lower methionine density. Olive oil, fiber, polyphenols. It hits every lever this paper describes without a single scoop of powder.

Lamming's own lab tested it: a low-protein diet modeling the traditional Mediterranean and Okinawan patterns, head-to-head against Western and ketogenic diets. Western and keto increased fat mass and frailty. The Mediterranean-style diet reduced both and improved cardiometabolic markers.

Traditional Okinawa ran about 9% of calories from protein.

The blue zones didn't drink protein shakes.

They ate beans, and they moved every single day.

[Afshine Emrani MD FACC @afshineemrani]

@Outdoctrination https://t.co/OEHJ01t7vd

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. A review published this morning just took a sledgehammer to the protein-maxxing era. And the most important detail isn't in the headline — it's buried in the human data. Lamming's lab at Wisconsin reviewed over 350 studies on protein restriction and aging, published today in Cell Press Blue. As @EricTopol put it, they define — for the first time — the hallmarks of protein restriction:

Improved metabolic health. Induction of nutrient-sensing pathways. Decreased senescence. Improved mitochondrial function. An altered epigenome. And the promotion of healthy aging.

Six hallmarks. From eating less protein, while still meeting your needs.

𝗧𝗵𝗲 𝗻𝘂𝗺𝗯𝗲𝗿𝘀 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗺𝗼𝗱𝗲𝗹𝘀

Flies: up to 122% longer life. Rodents: 10-50%+ gains. Methionine restriction alone: 7-42% lifespan extension. Cutting isoleucine and valine: 23-65% in various setups — with less frailty and less cancer.

𝗧𝗵𝗲 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺 𝘀𝗵𝗼𝘂𝗹𝗱 𝘀𝗼𝘂𝗻𝗱 𝗳𝗮𝗺𝗶𝗹𝗶𝗮𝗿

Excess protein — especially leucine, isoleucine, valine, and methionine — keeps mTOR switched on. mTOR is the growth accelerator. Keep it humming and autophagy shuts down, cells stop cleaning house, and senescent "zombie" cells accumulate.

Restrict protein and it reverses. mTOR quiets. GCN2 activates autophagy. And FGF21 surges — driving fat burning, insulin sensitivity, and lower inflammation.

This is the exact pathway rapamycin targets. The exact pathway fasting targets. We've been chasing it with drugs while telling everyone to eat more of the thing that blocks it.

𝗧𝗵𝗲 𝗵𝘂𝗺𝗮𝗻 𝗱𝗮𝘁𝗮 — 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗳𝗶𝗻𝗱𝗶𝗻𝗴 𝘁𝗵𝗮𝘁 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝗲𝘃𝗲𝗿𝘆𝘁𝗵𝗶𝗻𝗴

Levine's landmark Cell Metabolism study followed adults for 18 years. Those aged 50-65 with high protein intake had a 75% increase in overall mortality and a four-fold increase in cancer death.

But here's the line nobody quotes: those associations were abolished or attenuated when the protein was plant-derived.

Same amount of protein. Different source. Different outcome.

And the age flip matters enormously: over 65, high protein was associated with reduced mortality. Your protein needs change with age — in the opposite direction from what the influencers say.

𝗧𝗵𝗲 𝗵𝗼𝗻𝗲𝘀𝘁 𝗰𝗮𝘃𝗲𝗮𝘁𝘀

Topol's own caution is right: this review rests largely on model organisms. So does most of the healthspan literature, including rapamycin — but "true in mice" isn't "true in humans," and I won't pretend otherwise.

And Lamming himself gave the nuance that saves this from being clickbait: athletes consume enormous protein without developing metabolic disease. He suspects exercise protects them — the protein goes into building muscle instead of idling in growth pathways.

So the finding isn't "protein is bad." It's that protein without exercise may be the problem. A sedentary person drinking protein shakes, eating protein cereal and protein water is chronically flooring a growth pathway with nothing demanding growth.

𝗪𝗵𝗲𝗿𝗲 𝗜 𝗹𝗮𝗻𝗱, 𝗮𝘀 𝗮 𝗰𝗮𝗿𝗱𝗶𝗼𝗹𝗼𝗴𝗶𝘀𝘁

If you're sedentary and eating 1.5-2g/kg because an influencer told you to — the data doesn't support it, and it may be working against you.

If you lift hard 3-4x a week, that protein has somewhere to go. Different equation.

And if you're over 70 or frail — do not cut your protein. Sarcopenia will kill you faster than mTOR will. Older adults and pregnant women need more, and the authors say so explicitly.

I still believe the Mediterranean diet is the best diet on earth, and this review is the mechanistic explanation of why.

It delivers moderate protein — mostly plants, legumes, nuts, fish. Lower methionine density. Olive oil, fiber, polyphenols. It hits every lever this paper describes without a single scoop of powder.

Lamming's own lab tested it: a low-protein diet modeling the traditional Mediterranean and Okinawan patterns, head-to-head against Western and ketogenic diets. Western and keto increased fat mass and frailty. The Mediterranean-style diet reduced both and improved cardiometabolic markers.

Traditional Okinawa ran about 9% of calories from protein.

The blue zones didn't drink protein shakes.

They ate beans, and they moved every single day.

[Afshine Emrani MD FACC @afshineemrani]

@EricTopol https://t.co/OEHJ01t7vd

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. A review published this morning just took a sledgehammer to the protein-maxxing era. And the most important detail isn't in the headline — it's buried in the human data. Lamming's lab at Wisconsin reviewed over 350 studies on protein restriction and aging, published today in Cell Press Blue. As @EricTopol put it, they define — for the first time — the hallmarks of protein restriction:

Improved metabolic health. Induction of nutrient-sensing pathways. Decreased senescence. Improved mitochondrial function. An altered epigenome. And the promotion of healthy aging.

Six hallmarks. From eating less protein, while still meeting your needs.

𝗧𝗵𝗲 𝗻𝘂𝗺𝗯𝗲𝗿𝘀 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗺𝗼𝗱𝗲𝗹𝘀

Flies: up to 122% longer life. Rodents: 10-50%+ gains. Methionine restriction alone: 7-42% lifespan extension. Cutting isoleucine and valine: 23-65% in various setups — with less frailty and less cancer.

𝗧𝗵𝗲 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺 𝘀𝗵𝗼𝘂𝗹𝗱 𝘀𝗼𝘂𝗻𝗱 𝗳𝗮𝗺𝗶𝗹𝗶𝗮𝗿

Excess protein — especially leucine, isoleucine, valine, and methionine — keeps mTOR switched on. mTOR is the growth accelerator. Keep it humming and autophagy shuts down, cells stop cleaning house, and senescent "zombie" cells accumulate.

Restrict protein and it reverses. mTOR quiets. GCN2 activates autophagy. And FGF21 surges — driving fat burning, insulin sensitivity, and lower inflammation.

This is the exact pathway rapamycin targets. The exact pathway fasting targets. We've been chasing it with drugs while telling everyone to eat more of the thing that blocks it.

𝗧𝗵𝗲 𝗵𝘂𝗺𝗮𝗻 𝗱𝗮𝘁𝗮 — 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗳𝗶𝗻𝗱𝗶𝗻𝗴 𝘁𝗵𝗮𝘁 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝗲𝘃𝗲𝗿𝘆𝘁𝗵𝗶𝗻𝗴

Levine's landmark Cell Metabolism study followed adults for 18 years. Those aged 50-65 with high protein intake had a 75% increase in overall mortality and a four-fold increase in cancer death.

But here's the line nobody quotes: those associations were abolished or attenuated when the protein was plant-derived.

Same amount of protein. Different source. Different outcome.

And the age flip matters enormously: over 65, high protein was associated with reduced mortality. Your protein needs change with age — in the opposite direction from what the influencers say.

𝗧𝗵𝗲 𝗵𝗼𝗻𝗲𝘀𝘁 𝗰𝗮𝘃𝗲𝗮𝘁𝘀

Topol's own caution is right: this review rests largely on model organisms. So does most of the healthspan literature, including rapamycin — but "true in mice" isn't "true in humans," and I won't pretend otherwise.

And Lamming himself gave the nuance that saves this from being clickbait: athletes consume enormous protein without developing metabolic disease. He suspects exercise protects them — the protein goes into building muscle instead of idling in growth pathways.

So the finding isn't "protein is bad." It's that protein without exercise may be the problem. A sedentary person drinking protein shakes, eating protein cereal and protein water is chronically flooring a growth pathway with nothing demanding growth.

𝗪𝗵𝗲𝗿𝗲 𝗜 𝗹𝗮𝗻𝗱, 𝗮𝘀 𝗮 𝗰𝗮𝗿𝗱𝗶𝗼𝗹𝗼𝗴𝗶𝘀𝘁

If you're sedentary and eating 1.5-2g/kg because an influencer told you to — the data doesn't support it, and it may be working against you.

If you lift hard 3-4x a week, that protein has somewhere to go. Different equation.

And if you're over 70 or frail — do not cut your protein. Sarcopenia will kill you faster than mTOR will. Older adults and pregnant women need more, and the authors say so explicitly.

I still believe the Mediterranean diet is the best diet on earth, and this review is the mechanistic explanation of why.

It delivers moderate protein — mostly plants, legumes, nuts, fish. Lower methionine density. Olive oil, fiber, polyphenols. It hits every lever this paper describes without a single scoop of powder.

Lamming's own lab tested it: a low-protein diet modeling the traditional Mediterranean and Okinawan patterns, head-to-head against Western and ketogenic diets. Western and keto increased fat mass and frailty. The Mediterranean-style diet reduced both and improved cardiometabolic markers.

Traditional Okinawa ran about 9% of calories from protein.

The blue zones didn't drink protein shakes.

They ate beans, and they moved every single day.

[Afshine Emrani MD FACC @afshineemrani]

@xmetal_godx @messedupfoods https://t.co/OEHJ01t7vd

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. A review published this morning just took a sledgehammer to the protein-maxxing era. And the most important detail isn't in the headline — it's buried in the human data. Lamming's lab at Wisconsin reviewed over 350 studies on protein restriction and aging, published today in Cell Press Blue. As @EricTopol put it, they define — for the first time — the hallmarks of protein restriction:

Improved metabolic health. Induction of nutrient-sensing pathways. Decreased senescence. Improved mitochondrial function. An altered epigenome. And the promotion of healthy aging.

Six hallmarks. From eating less protein, while still meeting your needs.

𝗧𝗵𝗲 𝗻𝘂𝗺𝗯𝗲𝗿𝘀 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗺𝗼𝗱𝗲𝗹𝘀

Flies: up to 122% longer life. Rodents: 10-50%+ gains. Methionine restriction alone: 7-42% lifespan extension. Cutting isoleucine and valine: 23-65% in various setups — with less frailty and less cancer.

𝗧𝗵𝗲 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺 𝘀𝗵𝗼𝘂𝗹𝗱 𝘀𝗼𝘂𝗻𝗱 𝗳𝗮𝗺𝗶𝗹𝗶𝗮𝗿

Excess protein — especially leucine, isoleucine, valine, and methionine — keeps mTOR switched on. mTOR is the growth accelerator. Keep it humming and autophagy shuts down, cells stop cleaning house, and senescent "zombie" cells accumulate.

Restrict protein and it reverses. mTOR quiets. GCN2 activates autophagy. And FGF21 surges — driving fat burning, insulin sensitivity, and lower inflammation.

This is the exact pathway rapamycin targets. The exact pathway fasting targets. We've been chasing it with drugs while telling everyone to eat more of the thing that blocks it.

𝗧𝗵𝗲 𝗵𝘂𝗺𝗮𝗻 𝗱𝗮𝘁𝗮 — 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗳𝗶𝗻𝗱𝗶𝗻𝗴 𝘁𝗵𝗮𝘁 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝗲𝘃𝗲𝗿𝘆𝘁𝗵𝗶𝗻𝗴

Levine's landmark Cell Metabolism study followed adults for 18 years. Those aged 50-65 with high protein intake had a 75% increase in overall mortality and a four-fold increase in cancer death.

But here's the line nobody quotes: those associations were abolished or attenuated when the protein was plant-derived.

Same amount of protein. Different source. Different outcome.

And the age flip matters enormously: over 65, high protein was associated with reduced mortality. Your protein needs change with age — in the opposite direction from what the influencers say.

𝗧𝗵𝗲 𝗵𝗼𝗻𝗲𝘀𝘁 𝗰𝗮𝘃𝗲𝗮𝘁𝘀

Topol's own caution is right: this review rests largely on model organisms. So does most of the healthspan literature, including rapamycin — but "true in mice" isn't "true in humans," and I won't pretend otherwise.

And Lamming himself gave the nuance that saves this from being clickbait: athletes consume enormous protein without developing metabolic disease. He suspects exercise protects them — the protein goes into building muscle instead of idling in growth pathways.

So the finding isn't "protein is bad." It's that protein without exercise may be the problem. A sedentary person drinking protein shakes, eating protein cereal and protein water is chronically flooring a growth pathway with nothing demanding growth.

𝗪𝗵𝗲𝗿𝗲 𝗜 𝗹𝗮𝗻𝗱, 𝗮𝘀 𝗮 𝗰𝗮𝗿𝗱𝗶𝗼𝗹𝗼𝗴𝗶𝘀𝘁

If you're sedentary and eating 1.5-2g/kg because an influencer told you to — the data doesn't support it, and it may be working against you.

If you lift hard 3-4x a week, that protein has somewhere to go. Different equation.

And if you're over 70 or frail — do not cut your protein. Sarcopenia will kill you faster than mTOR will. Older adults and pregnant women need more, and the authors say so explicitly.

I still believe the Mediterranean diet is the best diet on earth, and this review is the mechanistic explanation of why.

It delivers moderate protein — mostly plants, legumes, nuts, fish. Lower methionine density. Olive oil, fiber, polyphenols. It hits every lever this paper describes without a single scoop of powder.

Lamming's own lab tested it: a low-protein diet modeling the traditional Mediterranean and Okinawan patterns, head-to-head against Western and ketogenic diets. Western and keto increased fat mass and frailty. The Mediterranean-style diet reduced both and improved cardiometabolic markers.

Traditional Okinawa ran about 9% of calories from protein.

The blue zones didn't drink protein shakes.

They ate beans, and they moved every single day.