The Aging Brain Lab

Barron lab @NTU_LKCMedicine @NTUsg
Neuroscience lab studying #mitochondria #metabolism #microglia #aging and #Alzheimers

[The Aging Brain Lab @AgingBrainLab]

📢New paper out in #PNAS on mitochondrial control of microglial phagocytosis.
🧵A brief thread
https://t.co/z3mUgJH2HD
@PNASnews @NTU_LKCMedicine @NTUsg @alzforum
#mitochondria #microglia #Alzheimers #Immunometabolism

[LKCMedicine @NTU_LKCMedicine]

Breaking boundaries in neuroscience! 🧠 Asst Prof Anna Barron (@AgingBrainLab), our new EMBO Global Investigator, explores mitochondria's role in brain health. Despite pandemic challenges, her commitment to knowledge remains unwavering.
Learn more: https://t.co/bFZRYN2neO

[EMBO @EMBO]

Putting mitochondria on the map: learn about new EMBO Global Investigator Anna Barron and her research on cellular metabolism as a regulator of microglial fate and function

https://t.co/mMFGlTd86z

[The Aging Brain Lab @AgingBrainLab]

What a great end to 2023! Very excited to join the EMBO Global Investigator network and looking forward to the new opportunities it brings!

[EMBO @EMBO]

Ten life scientists are welcomed to the EMBO Global Investigator Network, which provides access to the EMBO networking and training activities

https://t.co/pkfgnWxReU

[Chih Hung Lo @ChihHungLo]

Excited to share our Review Article published in Journal of Neuroinflammation where we discuss key mechanisms contributing to lysosomal acidification dysfunction in microglia. https://t.co/xbxKRKseYS Great collaboration with @JialiuZeng @jiahui_w20 @AMBarroness @AgingBrainLab!

[The Aging Brain Lab @AgingBrainLab]

Read more about our latest work here https://t.co/3w4tyrEJMy

[NTU Singapore @NTUsg]

💊 #NTUsg scientists may have found a way to spur brain immune cells into clearing toxic waste linked to #Alzheimers disease. This breakthrough could provide new possibilities for developing new drugs targeted at Alzheimer's disease. @NTU_LKCMedicine https://t.co/oL2CQBkhIz

[Medical Xpress @medical_xpress]

Study shows new way to spur brain #immunecells to clear toxic waste linked to #Alzheimer'sdisease @PNASNews https://t.co/RqqUBzhZYg https://t.co/BtHtBsJofC

[The Aging Brain Lab @AgingBrainLab]

💡Congratulations to lead authors @LaurenHFairley1 @KeiOnnL @jiahui_w20 and collaborators including @AnselmVincent @SarahRLangley @gdagstn
🧵 (7/7)

[The Aging Brain Lab @AgingBrainLab]

📢New paper out in #PNAS on mitochondrial control of microglial phagocytosis.
🧵A brief thread
https://t.co/z3mUgJH2HD
@PNASnews @NTU_LKCMedicine @NTUsg @alzforum
#mitochondria #microglia #Alzheimers #Immunometabolism

[The Aging Brain Lab @AgingBrainLab]

To restore the immune cells’ clean-up function 🧹, we “switched off” glycolytic metabolism by removing hexokinase-2 bound to the mitochondria.
This spurred microglia to gobble up 🍽️ toxic proteins that can build up in the brain 🧠 leading to Alzheimer’s.
🧵 (6/7)

[The Aging Brain Lab @AgingBrainLab]

Latest work from the lab. Mitochondrial control of microglial phagocytosis in Alzheimer’s disease https://t.co/9RAHN79I9A @LaurenHFairley1 @KnockOutinLab

[The Aging Brain Lab @AgingBrainLab]

@ForMolecular Fantastic work!

[The Aging Brain Lab @AgingBrainLab]

Our latest paper is out! Congratulations @LaurenHFairley1 !

[Dr Lauren H. Fairley @LaurenHFairley1]

Thrilled to share our recently accepted paper on the therapeutic effects of #TSPO in a model of tauopathy. @BioMedCentral @AMBarroness @AgingBrainLab @NTU_LKCMedicine @WomenAtNTU @alzassociation
https://t.co/Tx76Vpx7QB

[Dr Lauren H. Fairley @LaurenHFairley1]

Excited to share our new article "Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer’s Disease" @FrontImmunol @AgingBrainLab @NTUsg @WomenAtNTU @AMBarroness Jia Hui Wong
https://t.co/Qgo23qhM6H

[Anna @AMBarroness]

Our new paper out showing that the mitochondrial translocator protein is critical for brain steroidogenesis https://t.co/y81qrGd4gv

[Anna @AMBarroness]

Visualizing damaged mitochondria in Alzheimer’s mice https://t.co/6gXMVAx1yt

[Masafumi Shimojo @MasafumiShimojo]

Genetically targeted reporter imaging of deep neuronal network in the mammalian brain https://t.co/OBBzh8osKv