Alexis Maillard

PhD student in the HGID lab
Critical Care and Infectious Diseases - MD

[Alexis Maillard @AlMaillard]

1/ We are very pleased to share our recent work just published in @CIDJournal to improve the management of infections caused by wild-type AmpC beta-lactamase-producing Enterobacterales.

@BleibtreuAlexa1

https://t.co/FD6SKpIQkZ

[Aurélien Sokal @AurelienSokal]

Excited to share the latest work of our team published in Cell @CellCellPress 🎉
Congratulations to the team and all the collaborators!
@NeckerInem @casanova_lab @institutpasteur @PChappert @GorochovG
Read the paper here 👇https://t.co/FSltAG2pMl

[Matthieu Chaldebas @MChaldebas]

1/ Why do some genetic diseases remain unsolved even after whole-genome sequencing? The 5′UTR could hold the answer. In @AJHGNews, we present 5ULTRA, a new computational method to decode how these variants affect protein translation.

https://t.co/sE3sl9mrZZ

[Casanova Lab @casanova_lab]

1/ We are excited to report in @SciImmunology that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂https://t.co/fJ1QJ8JjBn

[Casanova Lab @casanova_lab]

1/ We are excited to share our new report in @PNASNews: all three cases of encephalitis triggered by the live-attenuated chikungunya (CHIKV) vaccine (IXCHIQ®) are due to pre-existing autoantibodies neutralizing type I IFN (AAN-I-IFN) (https://t.co/bR7wlUpUdE).

[Shen-Ying Zhang @ShenYingZhang1]

This is the 2nd severe live-attenuated viral vaccine disease, the 7th Arbovirus related disease, and the 11th severe viral disease, caused by human type I IFN autoantibodies: chikungunya live-attenuated vaccine encephalitis | PNAS https://t.co/P2BcFdxH4h

[Casanova Lab @casanova_lab]

Yet another reason to screen people over 65 years of age for type I IFN autoantibodies:

Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis | PNAS https://t.co/kNn5Nog8p3

[Vivien Béziat @BeziatV]

🧬 New in @CellGenomics 🧵
1/ With @CasanovaLab, we propose a rethinking of monogenic disorders of immunity:
👉 common variants can matter — a lot.

[Casanova Lab @casanova_lab]

Human inborn errors of the alternative NF-κB pathway https://t.co/M4ZrSpCfyW

[Alexis Maillard @AlMaillard]

https://t.co/6KJ22rn0mI

[Journal of Human Immunity @jhumimmunity]

Luciani, @BeziatV et al. report that patients with TAP1/TAP2 deficiency develop rubella-associated skin granulomas due to impaired HLA-I antigen presentation. Markedly elevated rubella IgG levels may support diagnosis when PCR is unavailable. https://t.co/Bij5neGJUw

[Journal of Human Immunity @jhumimmunity]

Alioua, Rosain @JRosain @hopital_necker and colleagues describe seven intronic pathogenic variants underlying inborn errors of immunity. https://t.co/9o3jcrhlWk

#InbornErrorsOfImmunity

[JAMA Neurology @JAMANeuro]

Case report: an atypical postvaccinal encephalitis in a 60-year-old man, with radial perivascular enhancement consistent with inflammation of glial fibrillary acidic protein–rich white matter loci. https://t.co/AyEzugwpPn

[Journal of Human Immunity @jhumimmunity]

Materna, @BeziatV et al. @institutimagine report children with complete TCRα deficiency, a lack of αβ T cells, & a severe condition. Previously characterized TCRα deficiency, which wasn't as severe as expected, was partial, as opposed to complete https://t.co/NM3i8zYyCB

[Alexis Maillard @AlMaillard]

@ElieAzoulay5 @ICM @yourICM

[Alexis Maillard @AlMaillard]

1/ Thrilled to share our latest study from the GRRR-OH group on critically ill immunocompromised patients, led by @ElieAzoulay5, and just published in Intensive Care Medicine (@ICM).

https://t.co/N3QuEMLy2z

👇

[Alexis Maillard @AlMaillard]

@ElieAzoulay5 @ICM 10/ 🙏 Grateful to @ElieAzoulay5 for his leadership, and to the entire GRRR-OH group and co-authors for their incredible work on this study.

📄 Published in @ICM: https://t.co/1NZAauC0cZ
Free link: https://t.co/N3QuEMLy2z