Alana Horowitz

PhD @ucsf

[Anthony Venida @AnthonyVenida]

It’s recruitment season and I’m here to tell you in 21 seconds why @UCSF is an incredible place to train!

On top of the fantastic programs @UCSFGradDiv has to offer, there are so many perks of living in San Francisco.

[Alana Horowitz @AlanaHorowitz]

@obiwormkenobi I want to be appalled on behalf of Bridgerton but it was a little too far south of satisfactory

[Alana Horowitz @AlanaHorowitz]

@AnthonyVenida You’re so cool and this is DEFINITELY going to work 🤞🏻🤞🏻

[Benoit Bruneau @benoitbruneau]

"single cell RNA sequencing reveals" in a paper title is the current science equivalent of "feat. Pitbull"

[McKnight Lab @McKnightLab_UO]

I'm raising money for Helping Laura and Katherine get through my death.. Click to Donate
https://t.co/NNO8Sko6o3

[Alana Horowitz @AlanaHorowitz]

@ACovarrubiasPhD @UCLA Hell yeah, Anthony!! Congratulations 🎉

[Alana Horowitz @AlanaHorowitz]

@obiwormkenobi It might just make me forget 2020 for two whole heartbeats

[Nathan LeBrasseur @NKLeBRASSEUR]

Harnessing the Effects of Endurance #Exercise to Optimize Cognitive Hea... https://t.co/0hFtENceQ7

[Alana Horowitz @AlanaHorowitz]

This is a wonderful article on our recent publication. I especially love the questions raised by experts in the field. Does Gpld1 correlate with clinical outcomes in humans? Does it interact with another brain-boosting protein, klotho? There's so much exciting work to be done!!

[Neurology Today @NeurologyToday]

Aged sedentary mice demonstrated increased #hippocampal #neurogenesis and hippocampal-dependent #memory benefit after receiving plasma from more active aged mice. Read on to learn more. #neurology @UCSFMedicine @VilledaLab https://t.co/ioUsLTDjg1

[Joe Udeochu @JUdeochuNeuro]

Thank you @BlackInNeuro for this opportunity. I am a post doc @LiGanLab where I study cellular and molecular mechanisms that lead to neurodegeneration. I model interactions between different cell types, organelles and pathways #BlackNeuroRollCall

[Villeda Lab @VilledaLab]

Luke's thesis work is now online in Aging Cell! In this study, we investigate the role of the aged hematopoietic system in driving cognitive decline, and identify Cyclophilin A as a pro-aging factor associated with aged HSCs: https://t.co/xjHuU5BCU0

[Alana Horowitz @AlanaHorowitz]

How much exercise is enough to trigger Gpld1? What target of Gpld1 enzymatic activity crosses the blood brain barrier? Will this translate to neurodegenerative disease states? I'm so excited to see @VilledaLab and the field pursue these questions in the future. (10/10)

[Alana Horowitz @AlanaHorowitz]

Essentially, Gpld1 recapitulated the benefits of exercise on cognition and neurogenesis. The ability to transfer the benefits of exercise to the brain has huge therapeutic potential, but many questions are outstanding: (9/10)

[Alana Horowitz @AlanaHorowitz]

To test if Gpld1 was part of the brain-improving signal in exercise, we increased levels of Gpld1 in aged mice. Gpld1 treatment improved the ability of old mice to learn and remember new tasks, and even increased the number of newborn neurons in their brains. (8/10)

[Alana Horowitz @AlanaHorowitz]

One of these liver-derived factors, Gpld1, correlated strongly with cognitive ability in aged mice. We also found higher levels of Gpld1 in the blood plasma of more active elderly humans (!!) in collaboration with @UCSFmac. (7/10)

[Alana Horowitz @AlanaHorowitz]

To figure out what might be responsible for this effect, we took an unbiased approach to to identify all of the factors that show up in blood after exercise. Surprisingly, we found that these factors weren’t coming from muscle or fat, but primarily from the liver. (6/10)