Gan Lab

We've moved to Bluesky! Please follow us there!

[Gan Lab @LiGanLab]

Our new study online today @MolNeuro shows that microglial DAP12 controls tau buildup and drives myelin loss by mediating a harmful tau-induced SLIT2 signal from neurons to oligodendrocytes https://t.co/fC8Dx5Cyfx

[Gan Lab @LiGanLab]

Follow us on Bluesky🦋!: https://t.co/eJUEAw6fjV

[Gan Lab @LiGanLab]

Lu et al. profiled >10,000 plasma & CSF samples to uncover how APOE2 & APOE4 confer divergent AD risk. APOE2 protects by sustaining homeostatic & anti-inflammatory signatures before Aβ accumulation, whereas APOE4 proteomic changes respond after pathology https://t.co/QWLkJrj2A5

[Gan Lab @LiGanLab]

Follow us on Bluesky🦋!: https://t.co/eJUEAw6fjV

[Gan Lab @LiGanLab]

Gan lab takes on Central Park zoo! Groups ideated, wrote and shot 2-4min short videos about intriguing CP zoo lore last Friday. Awesome time storytelling and collaborating with everyone!

[Gan Lab @LiGanLab]

Follow us on Bluesky🦋!: https://t.co/eJUEAw6fjV

[Gan Lab @LiGanLab]

In our latest preprint, we show microglia protect against levodopa-induced dyskinesia (LID): microglia-derived sTREM2 acts on TrkB, boosts BDNF-TrkB signaling, and points to plasticity as a potential Parkinson’s/LID therapy https://t.co/usYPduPC96

[Gan Lab @LiGanLab]

Follow us on Bluesky🦋!: https://t.co/eJUEAw6fjV

[Gan Lab @LiGanLab]

Excited to share our spotlight article in Cell Stem Cell on CAR-A astrocyte therapy for Alzheimer’s disease, an innovative approach for in vivo amyloid clearance. We discuss both the promise and the challenges ahead. 🧠
https://t.co/1pfjpP4Kup

[Gan Lab @LiGanLab]

Follow us on Bluesky🦋!: https://t.co/eJUEAw6fjV

[Gan Lab @LiGanLab]

New in Nature: de Faria et al. show focal white matter lesions trigger remote microglial response to demyelinated neurons in grey matter, which is required for remyelination. Deplete grey matter microglia→repair failures→chronic grey matter inflammation https://t.co/CfOxlaOJxZ

[Gan Lab @LiGanLab]

Follow us on Bluesky🦋!: https://t.co/eJUEAw6fjV

[Gan Lab @LiGanLab]

New collaborative study in Nature Medicine! Our AcTau174 antibody powers a sensitive CSF assay from Teunissen lab that cleanly separates FTLD-TDP from FTLD-Tau & tracks cognitive decline in AD & FTLD—enabling subtype-specific clinical trial enrollment https://t.co/rb9OwQ4R0M

[Gan Lab @LiGanLab]

Check out our earlier work: Immunotherapy targeting AcTau174 improves cognition in mouse models of TBI & tauopathy, establishing AcTau174 as a driver of cognitive decline https://t.co/iGZMkbRYxx

[Gan Lab @LiGanLab]

Follow us on Bluesky🦋!: https://t.co/eJUEAw6fjV

[Gan Lab @LiGanLab]

Paquet lab addresses iPSC limitation: new line with endogenous P301L/S320F 4R tau develops age-related tauopathy phenotypes stem cells typically fail to model. Platform shows pathological tau aggregation for more precise tauopathy research & drug screening
https://t.co/6SCxhFiiUv

[Gan Lab @LiGanLab]

Follow us on Bluesky🦋!: https://t.co/eJUEAw6fjV

[Gan Lab @LiGanLab]

MAPT p.R406W disrupts autophagy–lysosome pathway, impairing Tau degradation. Mutant neurons accumulate Tau/pTau in lysosomes, impairing motility, fusion, & clearance. Autophagy enhancement lowers Tau & restores degradation but doesn't rescue trafficking https://t.co/toEKdUHruY

[Gan Lab @LiGanLab]

Follow us on Bluesky🦋!: https://t.co/eJUEAw6fjV

[Gan Lab @LiGanLab]

The 13th Annual Appel Symposium on Mar 24 spotlighted the interconnectedness of neurodegenerative diseases. Drs. Sreeganga Chandra (Yale), Eddie Lee (UPenn), & Anna Orr (Appel) gave keynote presentations, preceded by over two dozen trainee posters from Appel & collaborating labs

[Gan Lab @LiGanLab]

Follow us on Bluesky🦋!: https://t.co/eJUEAw6fjV

[Gan Lab @LiGanLab]

PanNDA leverages deep proteomics of 2,279 human brain samples (AD, LBD, FTD-TDP-43, PSP, VD, & PD) to reveal shared disease mechanisms, spotlighting GPNMB (microglial/lysosomal activation) & NPTX2 (synaptic regulation). Data: https://t.co/bHaD0VgOCe Paper: https://t.co/tm3b1nzUBD