Alex J Keeley

Wellcome Clinical PhD in Global Health @mrcunitgambia @LSHTM. ID SpR @SheffieldHosp. Strep A, RHD, healthcare&climate justice, he/him, @alexjkeeley.bsky.social

[Alex J Keeley @AlexJKeeley]

🧵 New paper from MRC Strep A research team out today in @NatureMedicine

https://t.co/NJO7zTrMPN

On development of #StrepA #Immunity over life course in #TheGambia raising hope for vaccines on the horizon

1/

[Medical Xpress @medical_xpress]

#Identification of protective antibodies in children marks a major advance toward a #StrepA #Vaccine, offering potential to prevent hundreds of thousands of deaths worldwide each year. @sheffielduni @NatureMedicine https://t.co/EEXP8norJu https://t.co/mGrLB5NSOK

[Waggoner Lab @LabWaggoner]

[1/2] "Streptococcus pyogenes leads to 500,000 deaths annually, many due to rheumatic heart disease in low-income settings. Limited understanding of natural protective immunity to S. pyogenes hinders vaccine development." @NatureMedicine
https://t.co/CxmiNbeHI1

[MRC Unit The Gambia at LSHTM @mrcunitgambia]

#NewStudyAlert

🆕research led by scientists @mrcunitgambia @LSHTM uncovered vital evidence that could fast-track the development of a vaccine against Streptococcus pyogenes (Strep A), a major cause of childhood illness & death worldwide.

Read more 👉 https://t.co/qK5H8NFmgh

[Alex J Keeley @AlexJKeeley]

On this note:

Huge progress being made by @PendaJohm in establishing a community advisory board for Strep A research...

Many new projects underway, lots of opportunity to collaborate...

And substantial momentum towards Strep A vaccine trials @mrcunitgambia

fin/

[Alex J Keeley @AlexJKeeley]

🧵 New paper from MRC Strep A research team out today in @NatureMedicine

https://t.co/NJO7zTrMPN

On development of #StrepA #Immunity over life course in #TheGambia raising hope for vaccines on the horizon

1/

[Alex J Keeley @AlexJKeeley]

But biggest thanks to the families, the Alkalo, and community of Sukuta.

Sharing the first results with you was a special moment (https://t.co/nR6xCRwc9R)

We look forward to the next event to show just how impactful your contribution has been.

13/

[Edwin Armitage @edwinarmitage]

What a fantastic way to end the SpyCATS study! This study will answer so many important questions about Strep A epidemiology, transmission and immunology in The Gambia. Thank you so much to everyone who participated, and who worked to hard to make it happen!

[Alex J Keeley @AlexJKeeley]

Great thread:

Where #StrepA burden greatest frequent lineage replacement seen.

Interesting points:
"vaccines without broad cross-lineage protection may also lead to S. pyogenes lineage replacement."

"need to do better surveillance from carriage and non-invasive disease"

[Ouli Xie @ouli_xie]

Excited to share our latest research published in @LancetMicrobe exploring epidemiology and lineage dynamics of invasive S. pyogenes across diverse regions of Australia. https://t.co/iog3qG4C2t. A huge collaboration with many partners @syctong @MDaviesLab @rh_chisholm. 🧵👇

[Alex J Keeley @AlexJKeeley]

Building from:
https://t.co/ldCPtvtE1x

which you can read all about 🧵👇:
https://t.co/fyOvhGgQFI

Feedback and discussion welcome:

[Edwin Armitage @edwinarmitage]

🎉Our new study published today in @LancetMicrobe: SpyCATS longitudinal household cohort study of #StrepA carriage and infection and transmission in The Gambia! https://t.co/Mmx0MCux9M [1/7]

[Alex J Keeley @AlexJKeeley]

📢 Preprint - not peer-reviewed🤞:

Development of #immunity to #StrepA in The Gambia. We assessed IgG to conserved and M protein antigens across the life course, exploring association with protection against infection:

https://t.co/LoFbJEtq9w