Mark_Davies_Lab

Applied pathogen genomics laboratory at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Australia

[Ouli Xie @ouli_xie]

Pleased to share our latest paper @NatureMicrobiol on the emergence of antimicrobial resistant S. pyogenes lineages driving scarlet fever in China - a collaboration w Dr Yuanhai You and the China CDC @MDaviesLab @mark_uq @XinweiRuan @TheDohertyInst
https://t.co/u68koUDnLJ 🧵👇

[Mark_Davies_Lab @MDaviesLab]

Comparative clinical and genomic study of invasive SDSE v invasive S. pyogenes in Australia (and beyond). Rise of the clone..... SDSE stg62647! Beautiful work @ouli_xie (remember to read the supplementary material for more details). Powerful collaboration across borders. 🧵👇

[Ouli Xie @ouli_xie]

Excited to share our latest paper on invasive Streptococcus dysgalactiae subsp. equisimilis (iSDSE) disease in Australia and in a global context. @syctong @MDaviesLab https://t.co/YD4RR9hmoC

[Mark_Davies_Lab @MDaviesLab]

In press article out now @LancetMicrobe! https://t.co/OGnAJai1Fe

[Doherty Institute @TheDohertyInst]

Heard of SDSE? This under-recognised strep bacterium is causing a growing number of serious infections in Australia, with First Nations Australians disproportionately affected.
Learn more 🔗 https://t.co/sQScJXe7W7
@ouli_xie @syctong @MDaviesLab

[Mark_Davies_Lab @MDaviesLab]

Collaboration is the key! @TheDohertyInst @UniMelbMDHS @MenziesResearch @MonashHealth @WestSydHealth

[Ouli Xie @ouli_xie]

Excited to share our latest research published in @LancetMicrobe exploring epidemiology and lineage dynamics of invasive S. pyogenes across diverse regions of Australia. https://t.co/iog3qG4C2t. A huge collaboration with many partners @syctong @MDaviesLab @rh_chisholm. 🧵👇

[Mark_Davies_Lab @MDaviesLab]

Please read the next S. pyogenes genomic epi instalment from the laboratory (thread below). Huge amount of work by 'Dr Dr' @ouli_xie. Many thanks to the multitude of collaborators who contributed to this important work.

[Ouli Xie @ouli_xie]

Excited to share our latest research published in @LancetMicrobe exploring epidemiology and lineage dynamics of invasive S. pyogenes across diverse regions of Australia. https://t.co/iog3qG4C2t. A huge collaboration with many partners @syctong @MDaviesLab @rh_chisholm. 🧵👇

[Mark_Davies_Lab @MDaviesLab]

This study highlights the value of systematic investigations of publicly available (and high quality) bacterial genome sequences. The ability to direct future phenotypic investigations lies on developing tools and approaches to identify evolutionary cues hiding within genomes.

[Mark_Davies_Lab @MDaviesLab]

Excited to share our new lab work - driven by our fantastic PhD student (now Dr) @magnus_gj with @HayesScience @syctong: Cataloging of chromosomal inversions in #StrepA reference genomes. Sets an analytical framework for investigations in other pathogens. https://t.co/i5Jd55i5E2

[Mark_Davies_Lab @MDaviesLab]

Special thanks to Dr Aneley Getahun Strobel @HayesScience @wytamma @BenjaminHowden @MulhollandKim @DickStrugnell1 and many others - especially the hospital/public health workers in Fiji @MOHFiji @TheDohertyInst @UniMelbMDHS @MCRI_for_kids with support including @gatesfoundation

[Mark_Davies_Lab @MDaviesLab]

Pleased to share our latest collaborative research on the genomic epi of typhoid fever in Fiji published in @MicrobioSoc. Wonderful collaboration with public heath parters in Fiji/Aus. Evidence of 'selection' in the S. Typhi Vi capsule locus. https://t.co/qYknuplntX.

[Mark_Davies_Lab @MDaviesLab]

Honoured to be a member of the StrepA Outbreak Prevention Team @eurekaprizes 2024. Huge thanks to the many students and staff that facilitate the magic of team work and collaboration. Congrats to all #EurekaPrizes finalists!

[Doherty Institute @TheDohertyInst]

🏆 Huge congrats to @MDaviesLab from @TheDohertyInst who, together w/ collaborators at @IMBatUQ, won the prestigious #EurekaPrize for their crucial work on tracking Strep A spread and advancing vaccine development. [Watch https://t.co/6DLFvFHrn6]

@UniMelbMDHS @UniMelb @TheRMH

[Mark_Davies_Lab @MDaviesLab]

Out now: @magnus_gj latest PhD work: https://t.co/yLxZdHTouH Systematic evaluation of existing #StrepA transposon mutagenesis work using a pan-genome framework. Interactive html is included for searching of your favour strepA gene: https://t.co/IZuun1DolU @HayesScience @syctong

[Mark_Davies_Lab @MDaviesLab]

With an ageing population, we should be wary of the clinical burden of pathogens such as SDSE. Timely review led by the talented @ouli_xie. More clinical information on SDSE disease is needed (watch this space....)

[Ouli Xie @ouli_xie]

Is Streptococcus dysgalactiae subp. equisimilis (SDSE) just the poor cousin of S. pyogenes? Although it mostly causes disease in adults, there's actually much clinical and genomic overlap! See our review just out in CMR @syctong @MDaviesLab @TheDohertyInst https://t.co/7rdAfgp8pW

[Mark_Davies_Lab @MDaviesLab]

We have a research position in 'Microbial Bioinformatics' available in our laboratory. Masters/PhD level applicants with bacterial genomics experience are encouraged to apply. Come and join us @TheDohertyInst @UniMelbMDHS! Applications close 17 June 2024 https://t.co/gnpMy96zpt

[Doherty Institute @TheDohertyInst]

World-first research shows Streptococcus pyogenes (#StrepA) & emerging pathogen Streptococcus dysgalactiae subsp. equisimilis (#SDSE) coexist & share genes, opening up potential vaccine target pathways.
https://t.co/dqBtKH1Tbz
@ouli_xie @syctong @MDaviesLab @UniMelbMDHS @TheRMH

[Mark_Davies_Lab @MDaviesLab]

Excited to see our latest collaboration in print. Fantastic analysis driven by the talented @ouli_xie . Much still to learn about #strepA and #SDSE transmission and associated clinical genomic epidemiology. @TheDohertyInst @UniMelbMDHS https://t.co/Uh0c8VsCqp

[Ouli Xie @ouli_xie]

Great to share our latest paper in @NatureComms examining real-world transmission interactions between S. pyogenes and the emerging pathogen S. dysgalactiae subp. equisimilis (SDSE) https://t.co/2QtnQsXarj
@syctong @MDaviesLab @TheDohertyInst + many collaborators!
🧵👇

[Mark_Davies_Lab @MDaviesLab]

New global genomic framework for SDSE from our team at the @TheDohertyInst @UniMelb and @DrDaveMacca @usceduau with many international partners. Big shout out analytical skills of @ouli_xie. Refer to thread 👇for key messages. https://t.co/kPsoXigOG4 More SDSE news coming soon!

[Ouli Xie @ouli_xie]

Excited to share our Streptococcus dysgalactiae subsp. equisimilis (group C/G strep, SDSE) population genomics study highlighting its overlap with S. pyogenes (group A strep). Made possible by many partners @MDaviesLab @syctong @DrDaveMacca @TheDohertyInst https://t.co/X4X5y54tcu

[Nina van Sorge @N_van_sorge]

A great and inspiring 1.5 day visit to Doherty Institute and MCRI in Melbourne kindly hosted by Mark Davies and @JoshOsowicki Apparently just missed out on @Pink singing for the kids at the hospital yesterday. You rock 🤙!

[Mark_Davies_Lab @MDaviesLab]

Huge effort by a huge consortia! Amazing resource for the global community.

[ᐯIᑕTOᖇ ᑎIᘔET @victornizet]

Awesome🇦🇺team science @natcomms

Spearheaded by André Mu @muandre01 and anchored by Mark Walker @UQ_News, paper applies a standardized genomic, transcriptomic, proteomic + metabolomic tech framework to leading sepsis pathogens -> now open source for all!

https://t.co/XhOOpyFdev

[Mark_Davies_Lab @MDaviesLab]

@ElvyJuliet @NatureComms @TheDohertyInst @UQ_News @UniMelbMDHS sorry missed your question @ElvyJuliet Yes, multiple StrepA clones will be associated with changes in iGAS epidemiology. Our study targeted M1 StrepA, of which there are multiple sub-clones, including one clone with 3 extra virulence genes. Coordinated surveillance is key.

[Mark_Davies_Lab @MDaviesLab]

Excited to share our latest research which identifies the presence of the 'new' pandemic S. pyogenes clone 'M1uk' in Australian invasive #StrepA cases.
https://t.co/QP9TIn9vXn @NatureComms @TheDohertyInst @UQ_News @UniMelbMDHS

[Mark_Davies_Lab @MDaviesLab]

Timely review in @NatureRevMicro by our national team on the latest research developments in #StrepA pathogenesis, host responses, genomic epidemiology, AMR and vaccine development.
Including @magnus_gj @mark_uq @UQ_News @TheDohertyInst @UniMelbMDHS https://t.co/J4PnYosSGX

[David De Oliveira @DrDe_Oliveira]

Our team's latest work published in @NatureRevMicro. Here we cover the most recent advances and developments in Group A Streptococcal research
https://t.co/twWni5OTlN

Well done Stephan Brouwer, @tania_riv_her @MDaviesLab & team! #GroupAStrep