Alexander Fernández de la Torre

[Alexander Fernández de la Torre @Alexand35535548]

@CarinaDelpicco1 @LatinXChem Yes, when four equivalents of NaIO4 are added to the reaction we used water to solubilize this salt and add drop by drop

[Alexander Fernández de la Torre @Alexand35535548]

Hi @LatinXChem, this is my work ‘Multicomponent synthesis of peptoids containing α,β-didehydroamino acids’, #LatinXChem #LXChemOrg #OC044 #LatinXChem2021

[Alexander Fernández de la Torre @Alexand35535548]

@CarinaDelpicco1 @LatinXChem then sequentially, amine (0.2 mmol, 1.0 equiv.), the carboxylic acid (0.2 mmol, 1.0 equiv.), and isocyanide (0.2 mmol, 1.0 equiv.), were added. After completion, aqueous NaIO4 was added dropwise to the reaction, and the mixture was stirred at rt until the reaction was finished.

[Alexander Fernández de la Torre @Alexand35535548]

@CarinaDelpicco1 @LatinXChem The general procedure:
piperidine (0.01 mmol, 5 mol%) was dissolved in 0.8 mL of 2-MeTHF (0.5 M). then aldehyde (0.2 mmol, 1 equiv.), the solution was stirred for 10 minutes at 25°C. Then N-(Phenylseleno)-phthalimide (0.2 mmol, 60.4 mg, 1 equiv.) was added and stirred y 3h).

[Alexander Fernández de la Torre @Alexand35535548]

@CarinaDelpicco1 @LatinXChem In this protocol, I used 0.2 mmol, 1 equiv. of all reagents!

[Alexander Fernández de la Torre @Alexand35535548]

@CarinaDelpicco1 @LatinXChem Is a good question...in all compounds synthesized we cannot see the other isomer! Firstly, we assume that NMR analysis should be from the E and Z isomers of alkene but the results are from rotamers of tertiary amide bonds.

[Alexander Fernández de la Torre @Alexand35535548]

@CarinaDelpicco1 @LatinXChem The R1 is from the aldehyde and R4 is from the isocyanide component. As you can see in the scheme there is a mistake with the color of substituent, the blue should be for R1 and red for R4.

[Alexander Fernández de la Torre @Alexand35535548]

@CarinaDelpicco1 @LatinXChem Thanks for your comments!

[Sebastián Manríquez @Seba_MS1]

Hello everyone @LatinXChem ! Here's my work titled "Multicomponent synthesis of some computational derivative for application as metalloprotease inhibitors" for the #LXChemOrg category, poster number #OC086. #LatinXChem #Ugi4CR #docking

[Alexander Fernández de la Torre @Alexand35535548]

Direct Access to Tetrasubstituted Cyclopentenyl Scaffolds through Diastereoselective Isocyanide-based Multicomponent Reaction - now published in Chemical Science https://t.co/Rh8Ews45kE

[MWPaixão Group @mwpaixao]

Complexity and diversity in one shot! We have just published in @ChemicalScience a new isocyanide-based multicomponent reaction towards the assembly of complex and highly functionalized cyclopentenes !! @FAPESP, @ufscaroficial

[Elizabeth Magalhaes RSC-Brazil 🏳️‍🌈 MRSC @bethaquario]

#LatinXChemOrg fellows, while posting you posters \o/, register to our next webinar section on Organic Chemistry. https://t.co/oCHJMbCLpe

[Alexander Fernández de la Torre @Alexand35535548]

@Rossinha4 @LatinXChem Hi, @Rossinha4 and @LatinXChem some peptides having phosphonic acid have been employed in the '90s as LasB inhibitor but none was synthesized in a one-pot manner and not as peptoids scaffold.

[Alexander Fernández de la Torre @Alexand35535548]

"Hi @LatinXChem, this is my work "Synthesis of N–Alkylated phosphonopeptides as potential Inhibitors of LasB", #LatinXChem #LatinXChemOrg #OC027"

[Alexander Fernández de la Torre @Alexand35535548]

@Rossinha4 @LatinXChem Hi, @Rossinha4 and @LatinXChem I used Boc protected AA in the multicomponent reaction Ugi-4CR. After the product was obtained the boc and ester deprotection is done in a one-pot manner.

[Juliana Murillo @Juliana26176902]

@Alexand35535548 @LatinXChem Hi @Alexander35535548, that depends on what property do you want to analyze. But in general these reduced models give some hints about the energetics, which can be used as a starting point for condensed-phase calculations

[Walter Rabanal León @W_RabanalLeon]

@Alexand35535548 @LatinXChem Dear @Alexand35535548, till the date there is no experimental confirmation of aromaticity for these kind of systems. Since, aromaticity it is not a quantum observable there is no a direct physical concept to rationalize (or measure) it.

[Juliana Murillo @Juliana26176902]

@Alexand35535548 @LatinXChem In this work we found that at least under implicit water, the carboxylation of Propionyl-CoA coupled with Biotin reduced the energy barrier at around 20kcal/mol. Finally the enzyme will help to reduce the other part.. :D

[Alexander Fernández de la Torre @Alexand35535548]

"Hi @LatinXChem, this is my work "Synthesis of N–Alkylated phosphonopeptides as potential Inhibitors of LasB", #LatinXChem #LatinXChemOrg #OC027"

[Juliana Murillo @Juliana26176902]

Hi @LatinXChem, this is my work “Mechanism study of Biotin-dependent carboxylation reaction”, #LatinXChem #LatinXChemTheo #THEO047 by which we unravel the most thermodynamically favored path to conducted a carboxylation reaction using Biotin as carboxyl-carrier.

[Walter Rabanal León @W_RabanalLeon]

Hi @LatinXChem, this is my work "Revisiting Aromaticity Assessments in Inorganic Clusters", #LatinXChem #LatinXChemTheo #THEO042. This looks into the assignment of aromaticity in inorganic clusters, where the aromaticity measure can be ambiguous by the tool used on the analysis.