Alloutcoach

Inspiring #Performance & #Pharmaceutical #CompanyCulture. Adding #energy, excitement & character! #MIT certifed #coach + #mentor. Stretch Yourself, Lift Others!

[Alloutcoach @alloutcoach]

Check out the latest article in my newsletter: Inside The 2026 Medical Innovation Olympics Kick-Off at Rockefeller Center https://t.co/ms5Gc0c9QT via @LinkedIn

[Alloutcoach @alloutcoach]

Olympian & NHS advisor Chris Cook on why the 5th Annual 2026 Medical Innovation Olympics #MIO2026 @Rockefeller Center is the arena for future healthcare champions🏛️🏅Watch & register now (50% off with code JULY4MIO until July 11, 5 pm ET) 👇https://t.co/sX4zmsUUYM via @YouTube

[Alloutcoach @alloutcoach]

Here is how we kicked off the 5th annual Medical Innovation Olympics - https://t.co/6XE8qniMSN - you still have a chance to be a healthcare champion so sign up now to compete or attend https://t.co/gE2aIVk0OT use NYBIO code for 30% discount #MIO2026 #medicalinnovationolympics

[Lifespan @JoinLifespan]

Today, @lifebiosciences confirmed the first patient has been dosed with an epigenetic restoration drug candidate. An exciting milestone 🚀

Life Biosciences is the OG cellular rejuvenation using epigenetic restoration to reverse diseases of aging. It was cofounded by @davidasinclair, who serves as Chairman

The company’s proprietary Epigenetic Restoration platform utilizes three transcription factors, OCT4, SOX2, and KLF4 (OSK), to restore older and damaged cells to a younger and healthier state. This innovative approach targets a root cause of aging at the epigenetic level, and has the potential to address a wide range of serious age-related diseases

The Phase 1 trial will evaluate the safety and tolerability of ER-100, with additional endpoints assessing visual function. ER‑100 is the first clinical candidate from Life Bio’s Epigenetic Restoration platform, which uses controlled expression of three transcription factors, OCT4, SOX2 and KLF4 (OSK) to restore cellular function by resetting the epigenetic code to more youthful patterns of gene expression

“This is an important moment for Life Bio and for the field of aging biology,” said David Sinclair, Ph.D., Co‑founder of Life Biosciences and Professor of Genetics at Harvard Medical School. “Our research has suggested that aging is driven in large part by the loss of epigenetic information, not irreversible damage. This clinical study represents the first opportunity to test whether restoring that information can ameliorate human disease.”

Beyond ER-100, the company is strategically broadening its therapeutic pipeline to address additional age-related diseases, underscoring the platform’s versatility and transformative potential.

“This milestone reflects years of rigorous scientific development and translational research,” said Sharon Rosenzweig‑Lipson, Ph.D., Chief Scientific Officer of Life Biosciences. “Our preclinical studies have demonstrated that controlled OSK expression can reset epigenetic patterns associated with healthy cellular function, improve tissue performance, and restore visual function in animal models. Advancing ER‑100 into the clinic is an important step toward translating epigenetic restoration into a new class of medicines for age-related diseases.”

Optic neuropathies represent a large unmet medical need. Current treatments primarily address risk factors, such as intraocular pressure in glaucoma, but do not directly target the damage to retinal ganglion cells. As a consequence, the disease often leads to irreversible vision loss despite treatment

Vision loss not only directly impacts patients’ lives, but also increases the risk of loss of independence, damaging falls, and depression and dementia due to social isolation, underscoring the need for disease-modifying therapies.

Beyond ER‑100, Life Bio is developing applications of its proprietary Epigenetic Restoration platform for multiple indications in a variety of organs, reflecting the broad therapeutic potential of this platform.

About Optic Neuropathies Optic neuropathies are a group of disorders characterized by damage to retinal ganglion cells (RGCs), the primary neurons connecting the eye to the brain. Because RGCs do not naturally regenerate, damage results in permanent vision impairment. One such optic neuropathy, open-angle glaucoma (OAG) is a chronic neurodegenerative disease and a leading cause of blindness in older adults

While often associated with elevated intraocular pressure, disease progression frequently continues despite treatment, and some patients suffer from OAG despite normal intraocular pressure. Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in adults over fifty. It involves sudden, painless vision loss due to insufficient blood flow, for which there are currently no approved treatments

About ER-100 ER‑100 is an investigational therapy in clinical development for the treatment of optic neuropathies including OAG and NAION. ER‑100 is designed to restore function in retinal ganglion cells using Life Biosciences’ Epigenetic Restoration platform, which utilizes controlled expression of three transcription factors, OCT4, SOX2 and KLF4 (OSK), to reset cellular gene expression patterns and restore cells to a more youthful and functional state. ER‑100 is currently being evaluated in a Phase 1 clinical trial. More information can be found at https://t.co/GDRzIctoot (NCT07290244): https://t.co/Jj9cnu2M6w

For more information, visit https://t.co/msih0JTYfF or follow on social media
https://t.co/pEGPJjFjnQ

[Alloutcoach @alloutcoach]

Check out this post on MIO2026 https://t.co/xJmpDWQdU2 via @walls_io

[Alloutcoach @alloutcoach]

https://t.co/Q9xDQsj7SV 5th annual Medical Innovation Olympics kicking off June 12 @ Rockefeller Center in NYC with the Trials Qualification Session 1 featuring some incredible startups, Olympians, healthcare executives

[Alloutcoach @alloutcoach]

Check out the latest article in my newsletter: From Promise to Proof: What #FTPharma NYC Means for #MIO2026 https://t.co/HxMAo3kYco via @LinkedIn
#MedicalInnovation
#Pharma
#HealthTech
#AmedeaPharma

[Alloutcoach @alloutcoach]

I am hosting 2026 Medical Innovation Olympics - Trials Session 1 @ the iconic Rockefeller Center in NYC. Join me, life science investors, leading scientists, Olympic champions to learn, compete, and connect! https://t.co/FZw5l2lrIj via @LumaHQ #MIO2026 #medicalinnovationolympics

[Alloutcoach @alloutcoach]

Check out the latest article in my newsletter: WHY MEDICAL AFFAIRS STILL STRUGGLES TO PROVE ITS IMPACT IN 2026 https://t.co/ftAviLtJuA via @LinkedIn

[Alloutcoach @alloutcoach]

Very personal podcast on Spotify https://t.co/zmsqpvAgvj...
Apple Podcasts Link https://t.co/XDDubtCbUF...
It premiered today on the Alloutcoach YouTube Channel at 12:00 pm ET: https://t.co/HlxUr3IYFo
#leadership #globalleadership #humanism #Sakartvelo
#ItalyGeorgia #Alloutcoach

[Alloutcoach @alloutcoach]

The Flames and Fireworks to Watch in Healthcare: #JPM2026 and #FTPharma https://t.co/lTbcsWESFV The first issue of the 9th year of the "InWeekend" journal is now published.

#JPM2026 #MIO2025 #FTPharma #AmedeaPharma #MIO2026 #MedicalInnovation #aihealthcare #medtech

[Alloutcoach @alloutcoach]

I have 4 (or 2) Speed Skating tickets for Feb 20 listed on the official Milano Cortina resale - DM me and I’ll tell you exact event so you can find it quickly Offer no: MC256529827 #MilanoCortinaOlympic2026 #speedskating #MilanoCorrina2026 #milanolympics

[Alloutcoach @alloutcoach]

Register here now for our first livestream broadcast of the year - an update on #JPM2026 #ftpharma MIO2025 + those who register will receive exclusive BONUS VIP Guest Pass to the 2026 Medical Innovation Olympics: https://t.co/ovBC6lp4HY. Live on LinkedIn https://t.co/AlGsxuyIdy

[Alloutcoach @alloutcoach]

https://t.co/AlGsxuyIdy join us live Jan 29 @ 12 pm #JPM2026 #MIO2025 #Ftpharma looking for speakers who attended JPM2026 - contact me w/ DM and your email if interested

[Alloutcoach @alloutcoach]

Living longer & better lives is a reality in 2026 w/ new leaps in precision of longevity science, gut microbiome testing + multi-omics being integrated into the clinic.
#MIO2025 Expert Panel on Apple Podcasts: https://t.co/qla60sktLp
#longevitymedicine #gutmicrobiome #multiomics

[Alloutcoach @alloutcoach]

What happens when pharma measures performance like the Olympics? I was a guest on the Industry Ignited podcast - do not miss this conversation
https://t.co/qBt5cJNjeY #medicalaffairsimpact #performancekpis #businessaccountability #amedeapharma

[Alloutcoach @alloutcoach]

https://t.co/O09PPaNMPo #longevitymedicine #longevityexpertpanel #MIO2025 #agingresearch #agingbiology #alzheimers

[Alloutcoach @alloutcoach]

Join an unforgettable #MIO2025 Medical Innovation Olympics Longevity Medicine all-star global expert panel premiering right now on YouTube https://t.co/VYVZTq5F6V and on Spotify https://t.co/aZixRuorSB #longevitymedicine @agingdoc1 #preventivemedicine #agingresearch

[Alloutcoach @alloutcoach]

Check out the latest article in my newsletter: No More Excuses in 2026: Healthcare Leaders Need a New Operating System https://t.co/34s3tQj6Op via @LinkedIn #businesslegacy #healthcareimpact #healthcareoperations #medicalaffairsimpact

[Alloutcoach @alloutcoach]

https://t.co/Nlqcf7HW1I How do you turn accountability into motivation on your Medical Affairs, pharma, biotech teams? We have the answer at https://t.co/seVVB8ZIBY via our ANCORA platform, and the real world daily applications to prove it. #medicalaffairsimpact #highperformance