Alpha-gal Syndrome Research

Sharing research on alpha-gal syndrome and related topics. Tweets≠medical advice.

[Alpha-gal Syndrome Research @AlphaGal_RES]

A superb review, with an especially in-depth look at the glycobiology of alpha-gal syndrome. Must-read for anyone with a serious interest in this topic.
https://t.co/z08OjUWF5F

[Bloodsucking Parasites @bloodSparasites]

A salivary histamine-binding protein from Rhipicephalus microplus and its evaluation as an anti-#tick vaccine antigen https://t.co/6CPj99GZFT VetParasitol

[Alpha-gal Syndrome Research @AlphaGal_RES]

@CzerwinsMarcin @alphagal_info Looking forward to reading this! My weekend treat.

[Marcin Czerwinski @CzerwinsMarcin]

New piece from our lab: alpha-Gal syndrome from a glycobiologist's perspective. How glycans in ticks' saliva immunize us, and how our immune system responds to similar glycans present in red meat.
https://t.co/dWWIF3NR97
@alphagal_info
#glycotime

[Sarah McGill @SarahMcGillMD]

@SameerRaoMBBS @alphagal_info @NGMJournal @mgrover_gi @AlphaGal_RES @RutgersIMRes Important review! Strong work💪💪💪

[Alpha-gal Syndrome Research @AlphaGal_RES]

"These parallels suggest that tick saliva induces an immunosuppressive macrophage phenotype that shares mechanistic features with macrophage reprogramming in chronic diseases."
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[Alpha-gal Syndrome Research @AlphaGal_RES]

Tick saliva reprograms macrophages into immunosuppressive hubs that regulate T-cell immunity in Rhipicephalus microplus infestation
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https://t.co/KsC0651VXS

[Alpha-gal Syndrome Research @AlphaGal_RES]

"Thus, in this first European study investigating anti-α-Gal antibody responses in patients with end-stage carotid stenosis, an association was noted between α-Gal-specific IgG levels and the presence of the disease. However, no association was observed between IgE sensitization to α-Gal and either the presence of the disease or phenotypic characteristics of carotid stenosis. Further studies are essential to delineate the potential role of α-Galspecific antibody responses in early-stage carotid atherosclerosis by incorporating younger age groups and a broader range of disease severities."
3/3

[Alpha-gal Syndrome Research @AlphaGal_RES]

IgE And IgG Antibody Responses to α-Gal and Association With Carotid Stenosis in Swedish Patients
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https://t.co/tUT235Elin

[Alpha-gal Syndrome Research @AlphaGal_RES]

"Emerging evidence suggests that α-Gal sensitization may also be implicated in coronary artery disease."

"This study constitutes the first European investigation of the clinical relevance of IgE and IgG antibodies to α-Gal in a cohort of patients with carotid atherosclerosis."
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[Alpha-gal Syndrome Research @AlphaGal_RES]

"Severe reactions to parenteral therapies containing alpha-gal may occur in patients who do not have alpha-gal syndrome, as was first noted in the evaluation of cetuximab anaphylaxis that led to the discovery of the alpha-gal syndrome. In this case, the patient reported having no problems eating mammalian meat. Similarly, in a recent study from Arkansas, 4 of 5 subjects with adverse drug reactions to F(ab′)2 or Fab and positive IgE for alpha-gal reported consuming mammalian meat without symptoms ."
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[Alpha-gal Syndrome Research @AlphaGal_RES]

Anaphylaxis to Antivenom in a Patient With Asymptomatic Alpha-Gal IgE Antibodies: A Case Report
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https://t.co/m46Va3Vlsi

[Alpha-gal Syndrome Research @AlphaGal_RES]

Shocking new data on the rising number of cases in KY and VA! More alpha-gal syndrome deaths!

[Alpha-gal Syndrome Research @AlphaGal_RES]

https://t.co/3es7Wp5GzV

[Alpha-gal Syndrome Research @AlphaGal_RES]

https://t.co/3es7Wp5GzV

[Alpha-gal Syndrome Research @AlphaGal_RES]

Alpha-Gal Syndrome in a Pediatric Patient From Northeast Florida
https://t.co/bq1EZe6f3r

[Alpha-gal Syndrome Research @AlphaGal_RES]

"Given Missouri’s prominent role in AGS epidemiology and the demonstrated feasibility of telemedicine approaches, a comprehensive evaluation of digital health applications for this condition is warranted to inform clinical practice and healthcare policy in the region."
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[Alpha-gal Syndrome Research @AlphaGal_RES]

Digital Health Solutions for Alpha-Gal Syndrome: A Scoping Review of Telemedicine Evidence and Applications
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https://t.co/0RFAtvfNZT

[Alpha-gal Syndrome Research @AlphaGal_RES]

"Overall, this research supports that screening of wild boar sera for anti-α-GAL antibodies could serve as a broadspectrum indicator for pathogen exposure, supporting its potential inclusion in integrated monitoring schemes, complementing traditional pathogen screening approaches."
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[Alpha-gal Syndrome Research @AlphaGal_RES]

Nothing to do with alpha-gal syndrome, but an interesting use of alpha-gal as a biomarker for monitoring wildlife for pathogen exposure:

Biomarkers of pathogen exposure in wild boar for integrated wildlife monitoring
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https://t.co/eOhSCYkyXN