Alzforum

A news and information resource website helping scientists advance AD research since 1996. Alzforum doesn’t endorse any specific product or scientific approach.

[Alzforum @alzforum]

A new protective variant, W276C, lowers ApoE oligomerization, while a new risk variant, R189C, increases its lipidation. #alzheimersdisease @StanfordMed @dundeeuni @CUAnschutz @salkinstitute https://t.co/XuzHpZVBli

[Alzforum @alzforum]

Annexin-A11 and CHMP2B act in quick succession to repair holes in the plasma membrane. ALS/FTD mutations derail the process. @UCL@KingsCollegeLon https://t.co/9hC0Q1gerA

[Alzforum @alzforum]

TMEM106B drops in the CSF as FTD worsens, suggesting it may be a good marker. However, this lysosomal protein falls in AD CSF and it naturally runs low in people who carry a protective TMEM106B variant. @UCSF https://t.co/Y1q7pyAGR1

[Alzforum @alzforum]

Plasma proteomics indicates APOE4 accelerates astrocyte aging. Older astrocytes increase the likelihood a person will get Alzheimer’s. @StanfordMed https://t.co/LPsimGCSyM

[Alzforum @alzforum]

At a MJFF conference in London, seven research groups shared progress toward developing a PET tracer for synucleinopathies @MichaelJFoxOrg https://t.co/Z57s6yMyyy

[Alzforum @alzforum]

Excess glycosylation in the #alzheimersdisease brain may weaken memory, and taking glucosamine may make this worse. @UF https://t.co/dKeaxrvaKQ

[Alzforum @alzforum]

Drawing blood from jugular vein enhances the sensitivity of AD biomarkers, particularly Aβ42/40. The better performance might not be worth the risk. @CQU1929 https://t.co/4O3SGXIBif

[Alzforum @alzforum]

Studying tau paired helical fragments? Then check your reagents. Some scientists appear to have used an antibody to plant homeodomain finger protein 1, a.k.a PHF1, instead of anti-tau antibodies. At least 25 studies are potentially affected. https://t.co/OLv4L49rhf

[Alzforum @alzforum]

Thanks to advancements in neuroscience and engineering, brain-computer interfaces are better than ever, giving computer speech and cursor control to a 45-year-old man with ALS—all in the comfort of his own home. @ucdavis https://t.co/d2i0YDDAPF

[Alzforum @alzforum]

At the second annual TDP-43 summit, scientists debuted a machine learning algorithm for detecting LATE from MRI scans and showed the first human data from a TDP-43 PET tracer. #amyotrophiclateralsclerosis #frontotemporaldementia @UWMadison @RushMedical https://t.co/GAWIkns5fV

[Alzforum @alzforum]

Filming axonal transport in live mouse brain, a study finds that mutant tau forms tau clusters on microtubules and clogs axonal transport before pathology develops. Inhibiting a tau kinase eased the congestion. @_U_C_L_ https://t.co/JZHpxVWieE

[Alzforum @alzforum]

Spatial transcriptomics spies pivotal microglial shifts over the course of AD, as the cells transition from dealing with plaques to tangles. @KU_Leuven https://t.co/jnbAm564Tg

[Alzforum @alzforum]

New research places microglia at the center of endothelial-astrocyte-neuron crosstalk necessary for metabolite flow to neurons during learning. @nyulangone https://t.co/h33z6yW5q6

[Alzforum @alzforum]

Circular RNA chaperones were more effective than linear ones at keeping TDP-43 soluble, acting at nanomolar concentrations. #amyotrophiclateralsclerosis #frontotemporaldementia @CAS_Science https://t.co/gSeP6n4vje

[Alzforum @alzforum]

A positive Alzheimer’s blood test correlated with worse cognitive performance and faster decline in a cohort of relatively healthy people in late middle age. #alzheimersdisease @UCSF https://t.co/dpvpcyDpM3

[Alzforum @alzforum]

Latest massive AD Meta-GWAS unearths 16 new risk loci and uncovers a further 25 risk variants in known loci. @PasteurLille https://t.co/t102oNzAJO

[Alzforum @alzforum]

Proteomic analysis of the leptomeninges in AD finds shifts in matrix remodeling and cell-signaling proteins @RushUniversity https://t.co/L72UAOHTqb

[Alzforum @alzforum]

Blocking neuronal membrane proteasomes triggers tau fibrillization. APE might exacerbate the process. @Columbia https://t.co/yvybvHRECv

[Alzforum @alzforum]

TPPP, a protein that aggregates with α-synuclein, can form fibrils. Their concentration in CSF distinguishes MSA from PD and related disorders. @FudanUniversity @CAS_Science https://t.co/RgmPeZ16uR

[Alzforum @alzforum]

A new way to trace neuronal proteins in the brain shows they drain through a variety of routes, and leave via their nearest exit. @GladstoneInst https://t.co/0XSBOdICWZ