Aml Labib

Renal pathologist

[Aml Labib @AmlLabib]

Glomerular crescents 🌙

❓What’s a crescent?

🔬Crescentic GN?

🧩 How are crescents formed?

🔬🗂 Types of crescents? ❗️Pseudo-crescents?
(1/6)
#renalpath #PathResidents #Pathbracket

[Boonyarit Cheunsuchon, MD @roboonya]

Atypical necroinflammatory interstitial nephritis can be seen in SLE patients. This lesion is similar to lesion seen lymph nodes of KFD patients https://t.co/cxK1eqhAvN

[Kanishk Gupta, MD @kanishk10246585]

An interesting case of Amyloid cast nephropathy with Lambda restriction in 62 yr, male with AKI. Diffuse congophilic casts with Apple green birefringence on polarising light.

[Xuanli (Shary) Tang @shary_tang]

73y,M,proteinuria for 40yrs(start with sudden NS, treat with ARB and TW, UP fluctuate+~++,no steroid use). Recent 24hUP12g,ALB15g/L, FSGS lesion with IgA++ deposits, diffuse FPE and mesangium EDD. Would you consider secondary FSGS due to IgAN, or primary FSGS with IgA deposits?

[Vikram Deshpande @Vik_deshpandeMD]

Can you access the WHO Blue Books when you need them? Pathologists, trainees and researchers worldwide: share your experience in our survey. All levels of access welcome.

https://t.co/1ClvGTAEUM

#Pathology

[Grace Choung, MD 박영이 @grace_choung]

Clinicopathologic spectrum of kidney disease in pregnancy - Kidney International Reports https://t.co/8T4OK4Gg9H

[Sanjeev Sethi @SethiRenalPath]

Kidney biopsy findings in a patient treated with complement inhibitor-pegcetacoplan. First one for me.

Glomeruli appear and vacuolated and washed out. The vacuoles are most prominent in the podocytes.

The interstitium also contains vacuolated cells.

Glomeruli appear non proliferative and were negative for Ig and C3 on Immunofluorescence.

However, there was extensive global glomerulosclerosis and tubular atrophy and interstitial fibrosis.

[Anthony Chang, MD (張賀文) @ChangUCanSpare]

Kidney biopsy in the diagnosis of IgA Nephropathy

https://t.co/kLNwtSm6t6

[Jonathan Zuckerman MD PhD @JZRenalPath]

Some of the best hump-like deposits are seen with cases of C3 GN. This case in a 50's y/o pt with monoclonal gammopathy https://t.co/gRy4WcaU0v. #renalpath #pathtwitter

[Grace Choung, MD 박영이 @grace_choung]

Clinicopathological Features of NELL1-Associated Membranous Nephropathy with Tubular Basement Membrane Deposits - Kidney International Reports https://t.co/9wmA5W5aF5

[Anthony Chang, MD (張賀文) @ChangUCanSpare]

Kidney-shaped Kimmelstiel-Wilson nodule in DN #renalpath

[Sanjeev Sethi @SethiRenalPath]

Tough case.

LM: granulomatous interstitial nephritis, extensive.
IF: negative.

Look carefully and you start seeing small foci of necrosis in glomeruli, surrounded by inflammation/rupture of Bowman’s capsule.

Dx: 1. Granulomatous interstitial nephritis. 2. Necrotizing glomerulonephritis, pauci-immune. (both possibly drug related).

30-yr woman with rash, serum creatinine 10, bipolar disorder-just started treatment. ANCA, other serology negative.

[Lester Thompson @HeadandNeckPath]

Cocaine-Induced Plasma Cell Dermatomucositis (CI-PCDM): Clinical and Histopathological Features of a UK Cohort
G Thermos, E Morrison, L Cuddy, et al.
https://t.co/TuWzcFU7OW
#HeadNeckPathol #HNPJ #HeadandNeckPath #Pathology #ENTPath #PathologyTweet

[AJKD @AJKDonline]

FREE Atlas of Renal Pathology: Lecithin–Cholesterol Acyltransferase (LCAT) Deficiency https://t.co/iRpXuquIzn #renalpath

[Jonathan Zuckerman MD PhD @JZRenalPath]

Young pt with family history of CKD, hyperuricemia, increased Cr. Fluffly thick ascending limb inclusions; blue on trichrome stain. Hyperplastic ER with dilated cisternae and stacked lamellar structure by EM. Characteristic for Uromodulin-related kidney disease. #renalpath

[Anthony Chang, MD (張賀文) @ChangUCanSpare]

Most outrageous TBM involvement by fibrillary GN ever. Occurs in 10-15% of cases, but usually not this extensive #renalpath

IgG IF and DNAJB9 IHC

[Boonyarit Cheunsuchon, MD @roboonya]

Drug-induced granulomatous interstitial nephritis in 60 yo man who had history of NSAID use #renalpath

[Grace Choung, MD 박영이 @grace_choung]

The ultrastructure of a cast: the art and science of renal tubular pathology: Ultrastructural Pathology: Vol 50 , No 3 - Get Access

#EM #ultrastucture #renalpath
https://t.co/QkgLwQNx5t

[Grace Choung, MD 박영이 @grace_choung]

Complement in Kidney Disease: Core Curriculum 2026 - American Journal of Kidney Diseases https://t.co/C2hmAQQSFi

[Priya Alexander, MD @MPAlexanderMD]

To confirm the interstitial amyloid was ALECT2 amyloid.

The patient was Hispanic. ALECT2 was likely an incidental finding.

Check out this very timely publication ⬇️

Co-occurrence of systemic anti-neutrophil cytoplasmic antibody-associa… https://t.co/nml5RspEUc

[Jonathan Zuckerman MD PhD @JZRenalPath]

Well developed example of medullary angiitis (https://t.co/oqTXYTE2Fx) in a case of MPO-ANCA associated GN. Neutrophils and hemorrhage in the medulla. Also plenty of active crescents in this case. #renalpath #pathwitter #nephrology