Ange Barberi

[Ange Barberi @AngeBarberii]

@MediumTrade En attendant Poxel , gensight pour s’en mettre plein les fouilles 😎

[Ange Barberi @AngeBarberii]

@sergiodde @VincentReliquet @Stuckelberger Pas mal

[Ange Barberi @AngeBarberii]

@craft_pascal Qu’attend @sanofi ou @Servier pour développer l’imeglimin en France pour les patients malades , @poxel est une société lyonnaise laissez à l’abandon . C’est vraiment honteux vivement que la presse s’empare du sujet

[craftum pascal @craft_pascal]

NOUVEAU CONGRES DE SUMITOMO le 9 octobre uniquement pour l'imeglimin ( twymeeg)https://t.co/mGdYasS1wO

[Ange Barberi @AngeBarberii]

@Boursicoter2016 T’es à côté de la plaque les actifs de la société valent des centaines de millions d’euros la question est de savoir quand est ce que les actifs seront valorisés à sa juste valeur

[Ange Barberi @AngeBarberii]

@SylvainTekris les big pharma @merckgroup @sanofi @bmsnews @AstraZeneca @OrbiMed les patients atteints de diabète de type 2 en occident #usa #europe attendent avec impatience ce traitement révolutionnaire disponible qu’au @japan

[Tekris Sylvain @SylvainTekris]

POXEL

Imeglimin Treatment May Improve Whole-Blood Fluidity and Influence Hemorheology in Patients with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the INFINITY Study

https://t.co/3vzr6iYdJL

[Ange Barberi @AngeBarberii]

@La_Melooow @Uther_pandragon

[Ange Barberi @AngeBarberii]

@ligue1plus @ogcnice @Uther_pandragon

[Ange Barberi @AngeBarberii]

https://t.co/yR1Av1XoVN

Nouvelle preuve scientifique pour la révolutionnaire molécule #imeglimin dans le diabète de type 2

[Ange Barberi @AngeBarberii]

@QuartzTrad Il est possédé lui 😂

[Ange Barberi @AngeBarberii]

@VieDeLaJoconde Océan elevens

[Ange Barberi @AngeBarberii]

@RapaNews L’imeglimin est bien meilleur que tous les autres antidiabetique que ça soit les sglt2 ou autres

[오창명 @changmyung1981]

🚨 Can a diabetes drug become a therapy for sarcopenia?

A new study in Journal of Cachexia, Sarcopenia and Muscle reports that imeglimin, a first-in-class mitochondrial-targeting antidiabetic agent, protects skeletal muscle from atrophy in both obesity and ageing mouse models. Rather than acting through classical anabolic pathways, imeglimin appears to suppress chronic inflammatory and oxidative stress programs within muscle.

🔬 Key findings:
• In HFD-induced obese mice, imeglimin increased the cross-sectional area of fast-twitch (Type IIX/D) EDL muscle fibers by 66% compared with untreated obese controls.
• In naturally aged mice, 12 weeks of treatment preserved EDL fiber size and improved grip strength despite no significant changes in systemic glucose tolerance.
• Transcriptomic analyses showed coordinated suppression of immediate-early genes, inflammatory pathways, and TGF-β-associated signaling, all molecular signatures linked to sarcopenia.
• In cultured C2C12 myotubes, imeglimin reduced palmitate-induced ROS production and inflammatory gene expression, suggesting a direct protective effect on myocytes.
💡 Why this matters
Current metabolic therapies—including GLP-1 receptor agonists and SGLT2 inhibitors—can reduce lean mass during weight loss, raising concerns about sarcopenia. In contrast, imeglimin demonstrated a distinct profile by preserving muscle while targeting mitochondrial stress responses rather than stimulating mTOR or other anabolic pathways. The data suggest that reducing redox-sensitive inflammatory signaling may represent a complementary strategy for maintaining muscle health during ageing and obesity.
⚠️ Important caveats
This remains a preclinical mouse study. Although previous clinical studies have reported improved muscle strength in patients with type 2 diabetes receiving imeglimin, definitive randomized trials evaluating muscle mass, function, and long-term outcomes in older adults are still needed.

📄 Paper:
Ye Y, Qian D, Nomura I, et al. Imeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing. Journal of Cachexia, Sarcopenia and Muscle. 2026.

🔗 DOI: https://t.co/Le9FLmEOV2

#Sarcopenia #MuscleBiology #Aging #Obesity #Mitochondria #Inflammation #Metabolism #Diabetes #Imeglimin #JCSM

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Imeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing

https://t.co/ug2ubCOMqh

[Ange Barberi @AngeBarberii]

@RapaNews @sanofi @merckgroup @AstraZeneca @bmsnews @novonordisk
Ils attendent quoi pour soigner les diabétiques en occident ?

[Rapamycin News @RapaNews]

Imeglimin: An Approved Diabetes Pill Just Made Old Mice Stronger https://t.co/PmGErRyK44

[Ange Barberi @AngeBarberii]

@ABESHI_WISE La santé a t’elle un prix ? Twymeeg est bien meilleur que les autres

[La Twitchance @LaTwitchance]

Le timbre de voix de ZERATOR ?

Incroyable. 😭

[Leon @Leon9_40]

Bro.. had everyone thinking they were on camera. 😆