@KimberlyBlumen1 Congratulations, Kim!! Richly deserved!!
What a long and winding road, hopefully not riddled with too many existential crises. Perhaps the impact of the work when eventually judged by history will turn out to be directly proportional to the number of RO1 submissions!
@ShohamTxID If anyone asks for the RCT CCP data in I/C pts, then ask them for the RCT dexamethasone data in I/C pts.
Severe COVID in immunocompetent pts ≠ prolonged COVID in I/C pts.
The only antibody therapy known to neutralize SARS-CoV-2 variants XBB.1 BQ.1.1 in vitro + available under FDA EUA for immunocompromised COVID is convalescent plasma from vaccinated/boosted donors.
Grateful to @giveblood for making CCP available!
We are so excited to gain such an incredible new class of incoming fellows today! Congratulations to each of you on all you have already accomplished. We cannot wait for you to join our Stanford ID family in a few short months!
@JessicaLittleMD Inpatient: RDV + hybrid CCP
Outpatient: pax, RDV maybe. Can’t use beb in prolonged cases b/c EUA limits. Haven’t set up CCP for outpatients but would be fine under EUA.
*Need more hybrid CCP data in I/C*
Impaired T cells worse than isolated impaired B cells in covid.
@RicardoLaHozMD@JessicaLittleMD Did you grow them from the patient’s T cells, use a matched related donor, or have a bank of HLA matched cells? Curious also whether it was under clinical trial protocol as other VSTs are and if you are accepting referrals.
Great news! Novavax COVID-19 vaccine just got authorized for 1st booster! Doesn’t matter what u got for 1st/2nd (primary series). Lots of ppl who had oddball symptoms after mRNA or J&J of unclear attribution have waited for this. Uses protein subunit tech, not mRNA.
Allergies are weird!! Thanks, @KatherineJWu, for “shedding” some light on cat allergies. The human body is a strange place. The more we learn, the stranger it gets. Glad your B cells and mast cells have made their peace with Calvin and Hobbes.
The DOWNSIDE of going from single to multi dose vials is wastage/also many of us in primary care still do PPD skin test (to test for TB) which is intradermal,but not all health workers are trained to do this.Nevertheless its an incredible boost for a dwindling supply of vax -fin
Novel COVID variants are likely arising from immunocompromised people.
~2-3% of the population is immunocompromised.
~100% of the population is impacted by novel variants.
We need to invest in preventing infection in immunocompromised people — globally.
It enrages me to hear immunocompromised patients say that their doctors told them they shouldn’t get vaccinated against covid because being immunocompromised means they won’t benefit from vaccination