Anrg

[Jess @MeetJess]

Alzheimer's Protein Detected in Long COVID Patients https://t.co/5Aws3UUsHc

[Michael | APC Injury @internetuserf12]

Not-so-fun fact: SARS-CoV-2 actually has the fastest RNA-copying engine known to science, allowing it to print its massive genome at a blistering 169 letters per second. But there’s a catch: it copies so fast it makes fatal errors. It only survives because it carries a unique proofreading enzyme (nsp14) that acts like a spell-checker. Without this enzyme to fix its mistakes, the virus cannot replicate and drives itself into instant extinction which is what novel antivirals are being designed to throw off.

[Manuel Ruiz @manruipa]

Where does fatigue really come from?

Long COVID.
ME/CFS.
Lupus.
Sjögren’s.
Multiple sclerosis.
Rheumatoid arthritis.
Psoriatic arthritis.
Axial spondyloarthritis.
Systemic sclerosis.
ANCA-associated vasculitis.
Sarcoidosis.
Inflammatory myopathies.
Myasthenia gravis.
Primary biliary cholangitis.
Crohn’s disease.
Cancer.
Infectious mononucleosis.

All of these are very different diseases.

But many of them can produce remarkably similar fatigue.

Why?

Maybe we have spent too long studying “the fatigue of each disease” separately.

And perhaps we should start studying the common biology of fatigue.

(1/44)🧵

[Psychiatry Excellence @psycheureka]

Autoimmune disease can look entirely psychiatric at onset.

Early presentations often mimic primary psychosis, mania or catatonia.

Here are 7 immune-driven brain changes every clinician should recognise 👇🧵

[Michael R Scoma MD @DrMichaelScoma]

The Vascular Dimension of Long COVID

One striking observation in Long COVID is how rarely endothelial dysfunction is considered, despite fatigue, cognitive dysfunction, exertional intolerance, and dysautonomia suggesting impaired microvascular regulation.

[Brain Inflammation Collaborative @BrainInflCollab]

New brain imaging research is shedding light on why so many people with ME/CFS feel like their brain is constantly running on empty.

Researchers found that parts of the brain appear to be operating as if they’re chronically starved of oxygen, even when oxygen levels in the blood are completely normal.

They’re calling this “virtual hypoxia.”

We broke down the study in plain language, including what the results actually mean (and what they don’t).

Read the full piece here: https://t.co/mAJVdanFmU

[Amy Proal, PhD @microbeminded2]

It's madness that most people in the healthspan-extension space do little to control the activity of #viral, bacterial, #parasite and other pathogens that can hack their bodies over time.

Come listen to me talk at the Liberty Hotel next Thurs where I will discuss how to change this by optimizing anti-pathogen treatment approaches!

https://t.co/6XIhPz54tB

[Anrg @Anrg007]

@PNASNews Still trying to cover up.

[Anrg @Anrg007]

@sleazeberg @PNASNews Yep there are millions who still think it's natural and billions of others who don't care. But one day the truth comes out and everyone loses their mind.

[Dr. Sabine Hermisson 🦋 @SabineHermisson]

„ME/CFS ist, wenn ein Gutachter dich für arbeitsfähig erklärt und der andere Gutachter dir assistierten Suizid genehmigt.“ (@cstroeckw)

Constanze Ertls Rede anlässlich der Verleihung des Robert Hochner-Preises.

Dringende Leseempfehlung!
https://t.co/DkNxqrwkkE

[Michael R Scoma MD @DrMichaelScoma]

The Neuroimmune Autonomic Model of Long COVID

Long COVID has been viewed through many lenses: viral persistence, immune dysregulation, autoimmunity, and latent pathogen reactivation. These may converge on a common downstream pathway: chronic autonomic dysfunction.

[Zdenek Vrozina @ZdenekVrozina]

That logic could include -
immunoadsorption, plasma exchange, IVIG, Fc-receptor modulation, complement modulation, interventions targeting B and plasma cells.
Not as a blanket strategy for all long COVID - but as a rational approach for the right immunological phenotype.

[Anrg @Anrg007]

@SalvMattera Yes one is more likely to develop LC if reinfected.

[Anrg @Anrg007]

@SalvMattera 💯

[Zdenek Vrozina @ZdenekVrozina]

In people with long COVID, arterial stiffness in the large vessels looked no different from people who’d recovered cleanly.
The deficit sits one level down - in the smallest vessels, and specifically in how fast they can react.🧵

[Friesein @Friesein]

@wtogami Great imaging. Long COVID remodels vasculature to be tortuous, just like this research.

[James Throt MBBS, MD, PhD, FRCPath @JamesThrot]

Of course, all of this neurological damage is a result of social media, screen time, lockdowns 6 years ago, and the shots.

It’s definitely not the neuroinvasive, brain damaging SARS-CoV-2, proven to disrupt white matter, cause neuroinflammation, and destroy/shrink grey matter.

[Anrg @Anrg007]

@Sunny_Rae1 @hannahspierMD My doctor says don't believe all these. People publish just for recognition. He says more research was published in last 5 years than the 100 years before combined.

They always find something to discard you. Even brain atrophy and infarcts are called as insignificant findings.