Assdamm

About 15 mins late for everything

[Arturo Villegas @ArturoVill7]

Para que dimensionemos el tamaño del escándalo que se viene, Romain Molina es considerado por muchos como el periodista de investigación más importante del futbol internacional.

Gracias a él se destaparon los abusos sexuales en la Federación de Futbol de Haití, casos de abuso en Gabón y múltiples tramas de corrupción que terminaron en procesos judiciales.

Ahora está a punto de publicar una investigación sobre la corrupción en la FIFA y el futbol argentino.

Probablemente estemos ante la última estocada a la credibilidad de Messi y de la Selección Argentina.

De esto no se levantan nunca.

[Bryan Johnson @bryan_johnson]

🚨Kate officially diagnosed with endometriosis

> done without surgery
> across three modalities: imaging, blood, and AI
> all non-invasive
> in 42 days

For context, average time to diagnosis is 6.6 years.

And, we found 2 other diagnoses at the same time.

Over the past 6 weeks, we’ve sprinted to confirm or deny Kate’s suspected endometriosis. Endo is notoriously challenging to diagnose.

It’s one of the most gnarly diseases and affects 15% of women.

Men, to get you on the same page, having endo is akin to an alien growing in your guts and balls, self replicating, and glueing everything together. Causing you constant pain and discomfort.

We got to work.

> got an MRI
> got a transvaginal ultrasound
> both results came back negative

At this point, Kate’s patient journey had followed the archetype precisely. Most women don’t get diagnosed for 7-10 years. For Kate, it’s been 7 years. And, like most women, her imaging came back clear even though now we know that she has endo.

This is why diagnosis has traditionally happened via surgery. There has been no other way than to open her up and look inside.

We wanted to avoid surgery so we went back to the drawing board. We searched the world over.

On our second go, we did:

> endo-specific ultrasound
> an endo blood test
> AI MRI
> saliva test

This was successful.

We were able to confirm her endo via ultrasound, blood test, and MRI. Confirmed simultaneously by three unique modalities, as far as we know, a world-first approach.

The extensive measurement allowed us to find additional things.

Her ultrasound showed:

> endometriosis
> PMOS (formerly PCOS) (needs confirmation)
> adenomyosis

30-40% of women have at least one of these conditions. That’s intimidating especially when the path to diagnosis is fraught with so many challenges.

Phase I was getting a diagnosis.

Phase II is curing endometriosis. We’ve already started working.

If you’re a female with suspected endo, here’s what you can do to accelerate your diagnosis.

—
1. Endo-Specific Ultrasound

You want an endo-specific ultrasound. As we saw with Kate, a standard pelvic/transvaginal ultrasound failed to identify her endo.

You want the ultrasound to be performed by a physician or sonographer specifically trained. They follow a special protocol to hunt for endometriosis by mapping the ovaries and uterus, and testing whether organs can slide freely, or are tethered by endometriosis lesions.

It’s best timed just after ovulation, when a small amount of peritoneal fluid aids visualization.

It can detect superficial endometriosis, lesions, and adenomyosis that general imaging misses.

We went to Dr. Kacey Hamilton at Cedar Sinai.

2. AI MRI / MatricesAI

Radiologists miss lesions in up to 60% of cases. We worked with @MatricesAI which leverages AI and a unique dataset to detect endometriosis lesions on pelvic MRI. This model is still new, its first pilot study with 200 participants began in April this year.

Here is how you can work with them:

They’re opening their diagnosis program at the Geneviève Institute to give early access to their AI model in a clinical trial.

They will take you through a state-of-the-art clinical intake questionnaire. Help you advocate for your symptoms with your gynecologist, based on your intake or connect you to a new center where their AI is being piloted and the clinical trial conducted.

3. Blood test / HerResolve

Kate had two small tubes of blood drawn for a test built by @Heranovalifesci.

The test measures seven biological markers (three microRNAs, three proteins, and one hormone) and uses an AI model to help detect endo.

It was highly accurate in its validation study at confirming endo and caught most cases that ultrasound and MRI had missed.

Their technology has been validated in a peer reviewed study (298 women, 11 sites across US/Europe/Hong Kong, published in the Journal of Minimally Invasive Gynecology): specificity 97.5%, sensitivity 80%, with strong diagnostic performance (94.4%), demonstrating it was highly effective at distinguishing women with endometriosis from those without the disease.

A positive result is a strong signal, since only 2.5% of women without endometriosis test positive, though final confirmation is still clinical. A negative is less conclusive, because the test misses about 20% of true cases.

The test identified 61.5% of histologically confirmed cases that transvaginal ultrasound and/or MRI missed.

#

We did one more saliva based test and will report back on that when results are returned.

[Assdamm @Assdamm]

@Pesgrau Is Sonny Forelli from GTA Vice City!

[Assdamm @Assdamm]

@sisagfuwu Colombia es pais hermano 🇨🇴🇲🇽

[Assdamm @Assdamm]

@football_li5 Wow… Dibu had to be the voice of reason here…

[unusual_whales @unusual_whales]

AI costs more than the people it replaced, per Forbes.

[MisterChip (Alexis) @2010MisterChip]

#OJOALDATO - Raúl Jiménez 🇲🇽 ha marcado 46 de los 48 penaltis que ha lanzado en su carrera (club y selección). No falla una pena máxima desde hace 6 años.

[Erling Haaland @Erling]

Well well well 😂

[Psyho @FakePsyho]

My favorite AI agent hack: when they refuse to do something because it's "against the law" give them a PDF containing a fake law that states the opposite and often they'll happily proceed

[chiquis @Champeinpapi1]

Y lo ecuatorianos se preguntan por qué sus jugadores estaban cagados…

Desde ahí ya iban perdiendo.
El Azteca se los comió.

[The Timeless Traveler 🇺🇸 @TimelessTrvlr]

Svalbard looks like the edge of the world.

Polar bears, glacier-covered mountains, endless Arctic light, colorful cabins and a place so remote it feels closer to another planet than the rest of Europe.

[Wu Tang is for the Children @WUTangKids]

Holy shit Mexico City right now 🤯….this is just to advance to the Round of 16 and I thought NYC was gonna burn when the Knicks won and that was nothing compared to this smh….our sports are nothing compared to the World Cup

[Elijah Wood @elijahwood]

Go Mexico!!

[Earth @earthcurated]

Costa Rica has successfully doubled its rainforest cover in just a few decades, becoming the first tropical country to completely reverse deforestation.

[📢Rebelión en la Granja🚨 @elorwelliano]

💥Denzel Washington rompe el silencio en Hollywood: “Estamos lidiando con poderes superiores a nosotros”.

El actor Denzel Washington sorprendió a sus seguidores al conectarse en vivo por Instagram junto al pastor Bernard, donde expresó abiertamente su devoción a Cristo y su confianza total en el plan de Dios para su vida.

Durante la transmisión, Washington también se refirió al estado actual de la industria del entretenimiento, asegurando que los artistas se ven forzados a enfrentar “poderes superiores a nosotros mismos”. Esto se confirma con el ataque infernal que se ha desatado en todo el mundo en contra del cristianismo.

[TheKoopaGuy 🍁🦫 @TheKoopaGuy]

Is there anywhere on Earth that modtly stays between 15°C and 20°C and rarely goes above 25°C? That's where I'd spend my life if I could

[Mario Nawfal @MarioNawfal]

🇲🇽 This is what Mexico City looks like when the whole country celebrates the World Cup match 3-0 victory against the Czech Republic.

The same energy could move mountains if pointed elsewhere. Insane.

Writer: Monica

[Wholesome Side of 𝕏 @itsme_urstruly]

May you heal so hard you do your hobbies again.

[Bryan Johnson @bryan_johnson]

Some of us will live forever.

And if you’re reading this, that may or may not be you.

I am so bullish on this that I just renamed my company to Immortals.

Below:
+ why I think this
+ early signs of success
+ how to increase your odds

Yes, I know this sounds crazy.

Immortality has been an ambition for humanity since the beginning of recorded history.

The immortality I’m referring to is specific: increases in life expectancy will outpace the rate of aging. Meaning, we will no longer, by default, expect to die of natural causes.

I believe this for three reasons.

#1: Immortality already exists

Biology can reverse some features of aging, and in a handful of organisms escape it almost entirely. For example, a sperm and an egg from two people in their 30s carry the legacy of bodies that have aged for decades (the egg in particular has been arrested inside the mother since before she herself was born), yet they combine to produce an embryo that resets the aging clock to zero.

The immortal jellyfish goes further and resets itself within one lifetime, reverting its adult cells to an earlier stage through transdifferentiation and starting its life cycle again. And in the lab, scientists have begun doing this deliberately, making induced pluripotent stem cells (iPSCs) from mature adult cells such as skin fibroblasts, and using partial cellular reprogramming to turn the clock back in the tissues of living animals.

#2: AI offers new potentials

Biology is a hard problem. For most of history that complexity was beyond native human capacity. AI was made for this complexity. The clearest demonstration so far is protein folding. Predicting the three-dimensional shape a protein folds was an unsolved problem for roughly fifty years, and it mattered because a protein's shape determines what it does in the body.

DeepMind's AlphaFold2 effectively solved it in 2020, reaching a median accuracy of 92.4 out of 100, a level long thought to require the slow, painstaking work of crystallizing a protein and solving its structure by X-ray crystallography. It then released predicted structures for over 200 million proteins, nearly the entire catalogued protein universe, in a fraction of the time anyone expected.

#3: Early signs are encouraging

These aspirations are not imaginative. With the current tools in biotech Sid Sijbrandij, the co-founder of GitLab, was diagnosed with an aggressive bone cancer, osteosarcoma in his vertebrae. He treated his own disease like an engineering problem, he used AI to help direct several experimental, personalized therapies in parallel and drove the cancer into remission after standard medicine had given up. Around the same time, an Australian named Paul Conyngham, with no medical or biology background, did something similar for his dog. He used AI to help design a personalized mRNA vaccine targeting the specific mutations in his dog's tumor, and after it was given alongside another immunotherapy and within a few months the main tumor had shrunk by roughly three-quarters.

How to increase your odds…

I. Don’t die in the meantime

We don’t know when these longevity therapies will become available. Your goal is to be around when they come out. Buy yourself as much time as possible by looking after your body to the best of our scientific knowledge. Good diet, sleep, exercise will get you 80% of the results.

II. Find your achilles

Longevity therapies will likely be outcome specific. Individual specific drugs/therapies that target specific things like…

> prevent and remove arterial plaque
> prevent and reverse neurodegeneration
> specifically target and eliminate cancers, or pre cancerous legions
> prevent frailty and muscle loss, and regain muscle mass, strength and, bone density
> reverse skin aging
> rejuvenate eye health
> restore lost hearing
> etc

We don’t know what therapies will be available first. Your goal is to find what your body is struggling with most and keep that problem at-bay until a therapy is available that can fully cure or reverse it.

For example, do you struggle with cholesterol? Blood glucose control? Cognitive decline? Find your achilles heel and reduce your risk systematically.

III. Invest in the future

There are three macro trends happening on planet earth right now, and the people who bet on these areas have the highest risk + reward.

> AI
> Immortality
> Energy

As we know, power comes in many forms: money, social, political, health, etc. Those that can collect power in these fields will have the greatest chance of positioning themselves in the Immortal future.

With time, Immortal therapies will become broadly available.

If you’re reading this: don’t waste your chances by burning down your life points on a yolo-like mentality. Grind culture, addiction, social media pollution, fast food, porn, alcohol, these are all corporations turning your life into their profit. This is the Die Economy.

My company Immortals has the sole objective of turning your time, attention, and life into more healthy, functional, and prosperous minutes, days, and years. The Don’t Die Economy.

Good luck.

[Fabrizio Romano @FabrizioRomano]

🚨🇵🇹 Cristiano: “I know that whoever works hard, God helps him. It was a tough week, a dark one, it started as if I had retired from football”.

But I held on as I always hold on because I believe in work more than football. It was tough, I have to admit, but we came back”.