Isacco Desideri

Radiation oncologist, University of Florence

[OncoAlert @OncoAlert]

Day FOUR of #ESTRO26 Coverage by OncoAlert 🚨
PERSIAN TRIAL (NCT03449719): a randomized phase II trial testing Apalutamide and SBRT for hormone-sensitive prostate cancer Presented by Giulio Francolini 🇮🇹
#RadOnc ☢️

The PERSIAN randomized phase II trial evaluated apalutamide ± SBRT in oligometastatic hormone-sensitive prostate cancer. Biochemical response rates were high in both arms, with no significant differences overall. A consistent numerical trend favoring SBRT was observed, particularly in patients with higher disease burden. Treatment was well tolerated, with limited interruptions. These findings suggest a potential role for SBRT alongside systemic therapy in selected patients.

@ESTRO_RT
@yasemin09896924
@LindaMrissa
@christian_roenn
@Valeriadionisi
@gerryhanna
@clchiang_hk
@mtugceyilmaz
@B_Tomasik
@gmpetrianni
@CiroFranzese1
@Atem84
@piet_ost
@brachyexpert
@BlanceS90
@The_PT_Explorer
@BarbaraJereczek
@Mat_Guc
@ZilliThomas
@AnnaKirby17
@PBlanchardMD
@achoud72

Pinging OA faculty
@MKnoll_MD
@_ShankarSiva
@Icro_Meattini
@seanmmcbride
@NiuSanford
@nataliagandur
@acampsmalea
@to_be_elizabeth

[Robert Fripp @frippofficial]

Join us in sending birthday greetings to the guitarist as we build a RF@80 song playlist celebrating his 80th year. Find out more at
https://t.co/IqD0oNp0Ua

[RohanKar @RohanKarMooN]

It sucks to see that the last time my recent repack posts (excluding reposting old ones) ever reached 100k views was more than a month ago, and even games like halo 2 (whose predecessor had 1m views) couldn't even reach 50k. Even changing to new format didn't helped so I'll stick to old one ig.

[Shankar Siva @_ShankarSiva]

#ESTRO26 - INTRAGO phase III trial Dr Frank Giordano investigated that dose escalation in #glioblastoma #braincancer. Using single fraction intra-operative #radiotherapy dose escalation did not improve outcomes. Congrats to authors completing this challenging trial!

[Isacco Desideri @Atem84]

Agreed. GBM is unfortunately a much more complex disease to be effectively treated only by tweaking dose and volume. #ESTRO2026

[Isacco Desideri @Atem84]

No improvement in oncological outcomes with intraoperative dose escalation in GBM patients. Time to shift from dose and volume to other approaches in this uncurable disease. #ESTRO2026

[Isacco Desideri @Atem84]

Long term outcomes of conventional fractionated re-irradiation in recurrent pediatric ependymomas: prolongs survival but concerns regarding long-term complications. #ESTRO2026

[Felix Ehret @FelixEhretMD]

What is the role of reirradiation for recurrent meningioma? Read our systematic review and meta‑analysis in @Advances_ASTRO!
@ASTRO_org @ESTRO_RT @LabRaleigh @joostverhoeff

https://t.co/37dc0IyO6R

[Isacco Desideri @Atem84]

2/ Interesting proof of concept multicentric trial just discussed in a lively CNS proofered paper session #ESTRO2026

[Isacco Desideri @Atem84]

1/ Promising targeted strategy in unmethylated GBM addressing both vasculogenesis (NOX-A12) and angiogenesis (Bevacizumab) #ESTRO2026 @OncoAlert

[Isacco Desideri @Atem84]

Inferior oncological outcomes as well as Qol

[Isacco Desideri @Atem84]

Non-inferiority was not demonstrated with 6x6Gy vs 30x2Gy in GBM patients #ESTRO2026

[Raphael Colantonio @rafcolantonio]

For people who want Dishonored3: rejoice, wait no more: Elon Musk just said gamers will be able to generate GTA6 before GTA6 comes out in minutes thanks to AI, so D3 should be a walk in the park. Right?

[Don Winslow @donwinslow]

I do not believe this story.

[Troll Football @TrollFootball]

Respect Italy ✊

[PDBrown @PDBrownOnc]

Editorial CATNON IDHmt Grade 3 Astrocytoma
· NO benefit concurrent temozolomide
· Sig benefit w/adjuvant TMZ
· MGMT NOT prognostic
· Poor prog CDKN2A/B homo deletion, PDGFRA amp, methy profile
https://t.co/e8wGebVHFI

[定 @de3dsoul]

That moment in a game when you know you were about to play a masterpiece

[Joe Y Chang @JoeChangMD]

In MD Anderson, we have treated all SBRT consecutive days including 54 Gy in 3 FX, 50 Gy (SIB GTV 60 Gy) in 4 Fx, 50 Gy (SIB GTV 60 Gy) in 5 Fx. We don’t observe any particular concerns for side effects and it is much convenient for our patients.

[NonsparseOncologist @5_utr]

Nobody:
Absolutely nobody:
Post SBRT lung sitting there for the last 3 years as fibrosis: 👁️👄👁️
Radiologist: “cannot exclude residual disease, clinical correlation recommended, suggest PET/CT, bronchoscopy, repeat CT in 6 weeks, and carrier pigeon to oncologist”

[Vatnik Soup @P_Kallioniemi]

@RyanAFournier This you?