Aparna Bhaduri

Assistant Professor at UCLA in the Department of Biological Chemistry

[Aparna Bhaduri @BhaduriLab]

@UCLA @biorxiv (5/5) Why it matters: In vivo ablation of NVP-associated programs remodels the tumor and significantly extends survival. These studies move us from descriptive atlases to a mechanistic, targetable understanding of tumor organization. Check them out!

[Aparna Bhaduri @BhaduriLab]

(1/5) How does glioblastoma maintain its immense heterogeneity? 🧠 Two new companion papers from the Bhaduri Lab @UCLA now on @bioRxiv offer a lineage-resolved view of GBM hierarchies. Let’s dive in! 🧵👇

https://t.co/ss3FWXWakN
https://t.co/DFRqbeEttO

[Aparna Bhaduri @BhaduriLab]

@UCLA @biorxiv (4/5) Next: Meet the NVP (Neurovascular Progenitor) 🧬. This rare population co-expresses neural and perivascular programs. Using patient-derived lineage tracing, we proved NVPs can bridge the gap, giving rise to both neural and mesenchymal fates.

[Aparna Bhaduri @BhaduriLab]

I'm incredibly proud to be a  part of the V Foundation's new PSA campaign because they’re 💯% in for Victory Over Cancer®!
The V Foundation gives 💯% of every dollar donated directly to lifesaving cancer research—no exceptions.
I'm so honored to be on this team!

[The V Foundation for Cancer Research @TheVFoundation]

We’re 💯% in for Victory Over Cancer®. We need to give everything we’ve got.

That’s why the V Foundation gives 100% of every dollar donated directly to lifesaving cancer research.

Our new PSA campaign showcases the incredible team it takes to achieve Victory Over Cancer®, featuring Cancer Survivor @chauntelowe and V Foundation Grantee, @BhaduriLab.

Give 💯% today: https://t.co/nR0LzFt3vj.

[Aparna Bhaduri @BhaduriLab]

@KonopkaLab Welcome to UCLA! Delighted to have you here!

[Aparna Bhaduri @BhaduriLab]

So excited to share this paper led by @ShivaniBaisi_MD! Check out iHOTT!!

[Shivani Baisiwala, MD MS @ShivaniBaisi_MD]

🧵Excited to share our new preprint introducing iHOTT - an autologous tumor-immune co-culture model that captures patient-specific responses in #Glioblastoma

💥Now on @biorxivpreprint: https://t.co/sQAnQg9MnS
📝From @BhaduriLab in collaboration with @UCLANsgy

[Aparna Bhaduri @BhaduriLab]

A huge thank you to the amazing collaborators and members of the Bhaduri Lab for their contributions to this study! Antoni Martija, @prnano9, @Jalbsoto, Dan Jaklic, @MilJessenya, Rista White, @JacquiMMartn1, Dakshesh Rana, @GeschwindLab

[Aparna Bhaduri @BhaduriLab]

Excited to present our new preprint led by @claudianguyen95 uncovering how thalamic input shapes human cortical development! We discover that thalamic axons promote upper layer cortical neurogenesis through NRXN1-mediated contacts with outer radial glia. https://t.co/cmdprwV7ch

[Aparna Bhaduri @BhaduriLab]

Our findings suggest that the early entry of thalamocortical afferents in human and nonhuman primate cortex mediates communication with cortical progenitors. This demonstrates that the human thalamus actively sculpts cortical architecture during early development! 🧩

[Stéphanie Baulac @BaulacS]

📢 Paper out! FCDII is more complex than expected - somatic mTOR-activating mutations affect multiple cell lineages, yet only a fraction become cytomegalic. Dysmorphic neurons show mitochondrial dysfunction. #Epilepsy #BrainMosaicism #Neurodevelpment

[Aparna Bhaduri @BhaduriLab]

@ArlottaLab Congratulations!! What amazing news!

[UCLA @UCLA]

A new UCLA study leverages computational methods and existing data to bring us closer to answering the question: How does the brain build itself?

@dgsomucla
@UCLAHealth
@UCLAstemcell https://t.co/EurWmjQK7T

[Nature Neuroscience @NatureNeuro]

Parallel meta-analyses of the human cortex in development (seven datasets) and adulthood (16 datasets) generated over 500 gene co-expression networks describing of cortical development, centering on peak stages of neurogenesis

@BhaduriLab @prnano9

https://t.co/hGcgujjeBR