Proyecto de I+D+i en líneas estratégicas.
Mutaciones somáticas y hematopoyesis clonal como factores de riesgo en aterosclerosis: del laboratorio a la clínica.
@AtheroClonal is a public-private collaborative project funded by @CienciaGob I+D+I Líneas Estratégicas 2021. We aim to unveil the connection between somatic mutations, clonal hematopoiesis driven by these mutations and atherosclerotic cardiovascular disease. Meet the team 🧵
Our latest paper -> On identifying the mutations driving clonal hematopoiesis using machine learning models - BoostDM-CH
Great team work by @SantiDemajo, @JoanEenric, @fmuinos et al
Tweetorial 👇
📢Investigadores del @CNIC_CARDIO descubren un nuevo factor de riesgo cardiovascular🫀: la hematopoyesis clonal.
➡️La colchicina es útil en las mutaciones del gen TET2.
➡️Los estudios se publican en @NatureMedicine y 'European Heart Journal'.
✍️@rocio79 https://t.co/ooKlMcpQTE
Exploring the chicken-or-egg dilemma between clonal hematopoiesis and atherosclerosis. Our latest study, published today in @NatureMedicine (https://t.co/S26bV9zs7N), addresses this critical question. Check out the thread below ⬇️
A longitudinal study finds that whereas clonal hematopoiesis confers an increased risk of #atherosclerosis, the reverse is not the case, arguing for a unidirectional effect of clonal hematopoiesis on atherosclerosis
https://t.co/ZhwDH9EBKv
Two new studies on mutated blood stem cells clones, appearing frequently in our blood with aging (known as CHIP)
—strong association with atherosclerosis https://t.co/AoLS1ErTEx
—benefit of colchicine, an anti-inflammatory agent, vs atherosclerosis in mice and heart attack in @UK_Biobank participants, with TET2 CHIP
https://t.co/vlX2LvdWHi
@josejfuster@NatureMedicine@ESC_Journals@CNIC_CARDIO
And another paper online simultaneously with #ESCCongress! With Dr. Valentin Fuster and colleagues @CNIC_CARDIO, we clarify the relationship between clonal hematopoiesis and atherosclerosis. @NatureMedicine https://t.co/4bYVH9ZBzt More details ➡️ https://t.co/ob4nfA8fku
Now online simultaneously with #ESCCongress! Colchicine as a promising candidate to prevent atherosclerosis in TET2-mutant clonal hematopoiesis. A great collaboration with @pnatarajanmd led by @MariaAZuriaga and @ZhiYu_ACGT. https://t.co/b0HhX26elt
Important new study in @JAMACardio linking clonal hematopoiesis to coronary artery disease in individuals with East Asian ancestry! https://t.co/L6YBg2RF6K Congrats to all authors @BennyCho8! Happy to write the accompanying editorial comment @CNIC_CARDIO : https://t.co/lrhzyi1wVw
An early Holiday present! @myoclonal researchers at @IRBBarcelona used machine learning to develop a data-driven approach to distinguish mutations that drive clonal hematopoiesis from non-drivers! Available as a preprint https://t.co/05RrcZ1wmB. Tweetorial 👇🏼
@miriam_diezd and @blrneble from @josejfuster group at @CNIC_CARDIO presented their work on somatic mutations, clonal hematopoiesis and subclinical atherosclerosis at the IV Interdisciplinary Human Genetics Congress last week, congratulations!