HYPATIAtrial

Multi centre RCT to look at the benefit of HYdroxychloroquine in women with AnTIphospholipid Antibodies in pregnancy

[Professor Beverley Hunt OBE (also on BlueSky) @bhwords]

What would be the most cost effective & acceptable RCT to assess thromboprophylaxis in pregnancy/ puerperium?
- using decision analysis & qualitative studies of women & healthcare professionals
- we found a RCT in obese postpartum women would be most valueable & acceptable

[Karen Schreiber @KarenS_LDN]

🥁We have written history today: We have included the first patient into the @AtrialHypati #HYPATIA after moving sponsors of our ongoing #pregnancy RCT from the UK to the EU!
Thank you team GSTT for the extraordinary work! 🥇🙌🏻 @bhwords @doyley1_ What mountains of bureaucracy! 🏔️

[saori abe inoue @ori_114]

Autoimmune diseases and adverse #pregnancy🤰 outcomes: an umbrella review - The Lancet https://t.co/oeV23oo35g

[Karen Schreiber @KarenS_LDN]

🚨: We held the 1st European HYPATIA study ⁦@AtrialHypati⁩ site initiation visit in Copenhagen today! What a feeling! We are fighting to complete the #RCT of HCQ in pregnant women with aPL/APS 🙏🙌🏻⁦@Christine_ga_⁩ ⁦@bhwords⁩ ⁦@SavinoSciascia⁩ 🇩🇰🇬🇧🇪🇺🌍

[Professor Beverley Hunt OBE (also on BlueSky) @bhwords]

Our retrospective review of the use of hydroxychloroquine in 521 pregnancies, adds to the data showing no evidence of ⬆️ rates of fetal abnormalities when 200-400mgs HCG daily are used in pregnancy

⁦@KarenSchreiber2⁩
⁦@AtrialHypati⁩
https://t.co/UYLoXPiMj8

[HYPATIAtrial @AtrialHypati]

How difficult it has been to run HYPATIA!

[Laura Andreoli @lauraandreoli80]

The challenge of conducting clinical trials in pregnant patients #LancetSummitRheum
@KarenS_LDN narrates the journey of @AtrialHypati 🤰
Difficulties in investigator initiated trials are several&diverse ⛔️
What are your insights? Any ideas how to move forward?
@TheLancetRheum

[Laura Andreoli @lauraandreoli80]

#ICAPA2022 🇦🇷

Prof Karen Schreiber 🇩🇰@KarenS_LDN discusses the use of #HydroxyChloroquine in #pregnancy with #antiphospholipidantibodies

Looking forward to the results of #clinicaltrials 📊
#HYPATIA actively recruiting

#APSmatters

@AtrialHypati @bhwords @SavinoSciascia

[Professor Beverley Hunt OBE (also on BlueSky) @bhwords]

This is phenomenal! Running @AtrialHypati has been such a struggle through #Brexit then #COVID19
This is the boost we need to open in Europe & finish this trial. @KarenS_LDN has been truly outstanding in raising support
👏👏👏👏👏👏👏

[Karen Schreiber @KarenS_LDN]

Thank you @novonordiskfond for believing in me #EmergingInvestigator. Your support for @AtrialHypati will allow our amazing team to complete the HYPATIA study! We are fighting to start in Denmark,Italy &the Netherlands! @bhwords @SavinoSciascia @MiddeldorpS #HCQinPregnancy #APS

[HYPATIAtrial @AtrialHypati]

This is a wonderful start to @AtrialHypati opening up in Denmark!!

[Karen Schreiber @KarenS_LDN]

Thank you @novonordiskfond for believing in me #EmergingInvestigator. Your support for @AtrialHypati will allow our amazing team to complete the HYPATIA study! We are fighting to start in Denmark,Italy &the Netherlands! @bhwords @SavinoSciascia @MiddeldorpS #HCQinPregnancy #APS

[Karen Schreiber @KarenS_LDN]

This team effort deserves another tweet: ladies & gentleman, @AtrialHypati sponsor green light to open recruitment achieved. Welcome @uclh 🙌🏻#HCQinPregnancy #APS @bhwords @doyley1_ @APS_ACTION @isth

[JTH @JTHjournal]

New article: Women with 1st venous #thrombosis #VTE are at risk of recurrence during #pregnancy De Moreuil @FCouturaud et al @CHRU_Brest show high VTE recurrence in postpartum despite thromboprophylaxis.
Maternal obesity is risk factor for VTE recurrence.
https://t.co/tHhcabGYQC

[Karen Schreiber @KarenS_LDN]

Favourite emails! #OneMorePatientRecruit #HCQinAPS The HYPATIA study @AtrialHypati will answer if HCQ improves pregnancy outcomes in pregnant women with aPL! Thank you GSTT team & thank you to all our patients! 🚀📈 @bhwords @SavinoSciascia @MiddeldorpS @Willtho76313310 @doyley1_

[Karen Schreiber @KarenS_LDN]

This made our day: opening my inbox, finding a HYPATIA @AtrialHypati randomisation email from our amazing Cambridge team @Willtho76313310! You are fantastic! #APS @bhwords @doyley1_ @SavinoSciascia #hydroxychloroquineInPregnancy

[Karen Schreiber @KarenS_LDN]

@lauraandreoli80 @AliDuarteMD @AtrialHypati We are working around the clock to make the @AtrialHypati happen! Patient recruitment is ongoing thanks to amazing teams at St Thomas’, Cambridge, Oxford, Royal Free LDN soon Univ College London, Liverpool and Europe 🇪🇺🇩🇰🇮🇹🇳🇱@bhwords @doyley1_ @Willtho76313310 @SavinoSciascia

[Karen Schreiber @KarenS_LDN]

Over the moon! Our fantastic team at @Ox_wrh have recruited their first patient into our multi centre RCT @AtrialHypati HYPATIA! 💫 Thank you all for your help! Next is Europe! @doyley1_ @bhwords @Willtho76313310 @SavinoSciascia @MiddeldorpS #neverGiveUp #HCQinAPS

[Karen Schreiber @KarenS_LDN]

Best start of the w/e: confirmation of one more patient enrolled into our RCT #HYPATIA @AtrialHypati! This study will answer the q wether HCQ improves pregnancy outcomes in pregnant women with aPL #pregnancyinrheumaticdisease #APS @bhwords @MiddeldorpS @Willtho76313310 @doyley1_

[HYPATIAtrial @AtrialHypati]

Hurrahs welcome to @AddenbrookesRPG being a site for HYPATIA!
Lovely to have @Willtho76313310 & his team on board - thank you for your efficiency & enthusiasm 😄

[Willthomas @Willtho76313310]

Really happy to open @AtrialHypati in our Trust @CUH_NHS today @KarenS_LDN @bhwords

[Professor Beverley Hunt OBE (also on BlueSky) @bhwords]

Great to be part of this living ⁦@WHO⁩ guideline on the utility of hydroxychloroquine to prevent #covid-19

Despite all the early hype, after reviewing all the evidence:-
“We recommend against administering hydroxychloroquine to prevent covid-19” https://t.co/GOi3Zami9h