We're a biotech building AI infrastructure for rare disease drug development and have been using @AnthropicAI models, among others. This week's announcement that Anthropic intends to develop preclinical programs in rare disease to learn and build better products for customers has made me think more deeply about how AI-native companies should architect their infrastructure to take advantage of both open and closed models.
I also watched Karp's recent interview and haven't stopped thinking about this:
"What the technical customers want is control over their compute, their models, their data stack, and their alpha. They want to know they own the means of production, and it's not being transferred to someone else."
It also aligns with @satyanadella recent essays, where he argues that durable advantage won't come from the models themselves, but from a company's domain expertise, evals, and the systems it builds around them.
I don't take that to mean companies shouldn't use frontier models. Quite the opposite. Foundation models are advancing at an incredible pace. But I do think it means companies need to be deliberate about what they own. Their data, workflows, institutional knowledge, and evaluations should for the most part remain under their control, while their infrastructure stays flexible enough to use the best model for each task. Recent examples like Fable's use in biology reinforce that it's unlikely a single model or provider will be the best choice for every task. The ability to combine both open and closed models will become increasingly important.
At the same time, Anthropic's announcement feels like validation of something we've believed at @MendraInc from the beginning: rare disease is an important frontier for AI and one that deserves far more attention. There are more than 10,000 rare diseases, most still without effective treatments. More attention, more models, and more companies building in this space is ultimately a good thing.
Today, we’re launching Mendra, a rare disease therapeutics company enabled by AI.
We’re announcing an oversubscribed $82M Series A co-led by @OrbiMed, @8vc, and @5amVentures with participation from @Lux_Capital and @Wing_VC.
Full announcement 👇
https://t.co/rjxxWMa3Nu
People on my insta are really posting “Alhamdullilah” under a post saying SHC bans ScrapFest… the post is literally a group of people dancing their hearts out and having fun… how bitter do you have to be in your own life to care about other people enjoying their life? FFS 🤬🤬
#WATCH: On #WorldSuicidePreventionDay, Atia Naqvi, a psychologist whose 24-year-old son ended his life in 2018, urges Pakistan to decriminalize suicide and create a world "where no child feels hopeless enough to end their life" @AtiaNaqvi70@azfarnaqvi16
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https://t.co/YVKNoxlu0o
Let's be clear: the Pakistani people did not do this to Pakistan –– we all did, and the high-emitting nations are most responsible.
Unless we end our species' addiction to fossil fuels, every country in the world will remain in the crosshairs of the climate breakdown.
Will we (women) ever be able to go to work on public transport without being harassed by a lowlife who asks for money/help and in the same breath says nasty Af things about you 🤬🤬🤬🤬🤬🤬
running theory: everyone feels 2 years younger than they actually are because the pandemic ate two years of growth and life experiences. No idea if it’s true for everyone, but it is for me and at least 5 other people I know 😂
Of course pregnancy can make one more prone to medical conditions and could require medical attention. But pregnancy on its own is not a medical condition
Someone I know described a mutual of ours as having a medical condition because she was pregnant.. pregnancy is NOT a medical condition. It is a natural process.