Charles Bayly-Jones

Investigating protein nanomachines and their dynamics.
ARC DECRA Fellow @MonashBDI.

Structural biologist. Author of WIGGLE. He/Him. 🏳️‍🌈

[Charles Bayly-Jones @bj_charles]

We are thrilled beyond words to see our LYCHOS (GPR155) publication out today in @Nature. 🥳

“LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR”
https://t.co/I7ibRphMzS

🧵

[Charles Bayly-Jones @bj_charles]

👀

[Charles Bayly-Jones @bj_charles]

Here's a little preview. Check out the manuscript for an unexpected finding!!

https://t.co/P2QdkCQf9V

[Charles Bayly-Jones @bj_charles]

Sometimes projects have a particular hurdle - this project had an avalanche. Every stage of the investigation was tough; cloning, purifications, freezing, analysis, function. This figure highlights the #cryoEM analysis.

[Charles Bayly-Jones @bj_charles]

Absolutely thrilled to see our latest study online @CellCellPress.

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex.

https://t.co/P2QdkCQf9V

@LuptonCJ @Dr_MLHalls & Andrew Ellisdon.
#cryoEM #KICSTOR #mTORC1 #GATOR1

[Charles Bayly-Jones @bj_charles]

https://t.co/70gVvLR6Sl

[Charles Bayly-Jones @bj_charles]

Earlier this year, I was incredibly honoured to receive the Premier’s Award for Health and Medical Research in the Basic Science category.

This recognition is a huge testament to the amazing work of our entire team. 🙌💥🎉

Photography and video: @vicgovau.bsky.social

[Charles Bayly-Jones @bj_charles]

Monash just got a huge upgrade - How a $60m computer called MAVERIC could change Australia’s AI future https://t.co/KYejdFJXLe

[Charles Bayly-Jones @bj_charles]

@bluesocks81 DeepSeek and Jaycar for the win... 🤣

[Hijai Regina Shin @HijaiShin]

Amidst the chaos, here's a belated but exciting highlight on the recent LYCHOS structure by @bj_charles @LuptonCJ @Dr_Ellisdon @Dr_MLHalls
@RobertoZoncu and I broke down their findings, explored future directions, and tackled the key remaining questions.
https://t.co/1ECXKjmG3D

[Mark Nelson @energybants]

The next nuclear reactor to be prematurely closed in Europe turns off February 15th, in the dead of winter.

[Daniel Fox @_danielfox]

The first major body of work from my PhD is now up on BioRxiv!

We used AI-designed binders to block the uptake of heme from hemoglobin through ChuA, a heme transporter found in pathogenic E. coli. 🦠🩸🔬

I’m very grateful for my supervisors and all coauthors for their support!

[Charles Bayly-Jones @bj_charles]

@chaidiscovery I'm come across a rather perculiar behaviour. Chai1 correctly models a complex fold when provided Cα-Cα constraints (as little as 2% work) with use_esm_embedding=False. However if I alter the sequence by even a single residue, the prediction fails... Any insight?

[Charles Bayly-Jones @bj_charles]

@JhonatanReales @LuptonCJ @ScienceAdvances @sci_laura @Dr_Ellisdon Many thanks! It has been a long project in the making...

[Charles Bayly-Jones @bj_charles]

@allostericstate @MonashBDI @MonashUni @CryoEM_Monash @HariVenugopal2 Thanks TJ - it certainly wasn't. We learnt the hard way that TSC is also quite prone to denaturing due to AWI issues and freezing. Not a trivial problem 😅 but we persevered and had fun!

[Charles Bayly-Jones @bj_charles]

🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in @ScienceAdvances .

Equal-first co-authors @LuptonCJ & @sci_laura. Work lead by @Dr_Ellisdon. Funding from @DeptofDefense & @arc_gov_au.

https://t.co/8JYixZHiQ2

[Charles Bayly-Jones @bj_charles]

@AlboMP Bad idea, bad policy. Focus on the things that matter - climate change, underfunded hospitals, tax inequality, housing crisis.

[Charles Bayly-Jones @bj_charles]

Work done @MonashBDI @MonashUni using our amazing @CryoEM_Monash facility. As always @HariVenugopal2 is indispensible to our success!

[Charles Bayly-Jones @bj_charles]

Finally TSC is extraordinarily flexible and is a massively difficult structural biology target. We had to use all the tricks we know to get this one... Parts of TSC can move by up to 10 nm!!!

[Charles Bayly-Jones @bj_charles]

@structureltp @ScienceAdvances @LuptonCJ @sci_laura @Dr_Ellisdon @DeptofDefense @arc_gov_au Thanks! It seems the field is exploding with structures recently.