Baolei Yuan

Bioscientist

[Mo @Mo_Li_KAUST]

New in @NatureComms simple 5′Cy5 modification of ssODN donors boosts CRISPR–Cas9 HDR, improves survival, and enables precise editing in human organoids and blastoids, reaching 30% sickle cell mutation correction
@KAUST_News @KAUST_BESE @KAUST_PSE @ShmsLab https://t.co/Iw3iDEKVWt

[Baolei Yuan @BLY36865709]

Excited to share our recent work on boosting CRISPR-Cas9 HDR efficiency using simple chemical modified ssODNs - 5'Cy5-ssODNs - in multiple stem cell models, just published in @NatureComms! Huge Thanks to my advisor @Mo_Li_KAUST and co-authors
Read it here: https://t.co/kG7kIqQRJ9

[Mo @Mo_Li_KAUST]

Our new paper: comprehensive analysis of CAS9-induced, unintended large insertions using various donor types reveals widespread integration of repetitive & regulatory elements & donor sequences, @ target sites ⁦@KaustResearch⁩ ⁦⁦@CommsBio⁩ https://t.co/3I8OmdbbYi

[Oxford Nanopore @nanopore]

.@Mo_Li_KAUST shares how his team in Saudi Arabia are leveraging nanopore sequencing to tackle unique genetic disorders in the region stemming from consanguinity — overcoming the limitations of traditional sequencing methods.

[Mo @Mo_Li_KAUST]

Our new strategy suppresses unwanted deletion events to make genome editing safer and more precise https://t.co/dURp39AB28 via @physorg_com @altos_labs @KaustResearch

[Baolei Yuan @BLY36865709]

Time flies!#MyXAnniversary

[Elliot Hershberg @ElliotHershberg]

Humans: nanotechnology will never work!!!

Bacteria: hold my beer.

[Mo @Mo_Li_KAUST]

Thanks @KaustResearch for highlighting our genome editing work. Stay tuned for more interesting finding in follow up studies. @BLY36865709 @nanopore @altos_labs https://t.co/D8JK0rvjUt https://t.co/D8JK0rvjUt

[Mo @Mo_Li_KAUST]

Our latest work on discovering the dark side of CRISPR-Cas9 using our IDMseq @nanopore sequencing method @KaustResearch @KAUST_SHI grateful for great collaborators at @KAUST_News @PKU1898 and @altos_labs
https://t.co/OgFYDleoTU

[Baolei Yuan @BLY36865709]

@Mo_Li_KAUST @altos_labs @KAUST_SHI @KaustResearch Thank Mo for the warm words. I appreciate your supervision during my PhD. It is hard to say goodbye for me, too. Looking forward to seeing more big publications and progress from our lab.

[Oxford Nanopore @nanopore]

iMiGseq is a potentially groundbreaking technique, that uses long nanopore sequencing reads to overcome the limitations of traditional mtDNA sequencing methods.

Learn how it provides comprehensive analysis of mtDNA in single cells: https://t.co/aUCjJOU7yd @Mo_Li_KAUST

[Mo @Mo_Li_KAUST]

My group members had a good discussion on career development with Prof Han Liang who visited KAUST Bioscience program from MD Anderson cancer center last week @KaustResearch @KAUST_SHI

[Mo @Mo_Li_KAUST]

Our article "Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing" received 3,591 downloads since its publication! @BLY36865709 @KAUST_SHI @KaustResearch @NatureComms Access the article here: https://t.co/g4ZvdKOZaG

[Baolei Yuan @BLY36865709]

@Mo_Li_KAUST @KAUST_News Thank Mo for your great supervision. You are the best mentor!

[Mo @Mo_Li_KAUST]

My lab welcomes postdocs with developmental biology and stem cell background

[Mo @Mo_Li_KAUST]

Thanks KAUST Discovery for highlighting our work. @KaustResearch @carlosduartephd @Samhan182 @SilviaArossa Bioreactor
keeps cell culture conditions under control https://t.co/EJo06yKVwW via @KAUSTResearch

[Mo @Mo_Li_KAUST]

Our work on CAS9 induced large deletions in bioRxiv @KaustResearch @BLY36865709 Modulation of the microhomology-mediated end joining pathway suppresses large deletions and enhances homology-directed repair following CRISPR-Cas9-induced DNA breaks https://t.co/I5MVh35fnL

[Prof. Feynman @ProfFeynman]

Religion is a culture of faith; science is a culture of doubt.

[Prof. Feynman @ProfFeynman]

Life is too short to worry about stupid things. Have fun. Fall in love. Regret nothing, and don't let people bring you down. Study, think, create, and grow. Teach yourself and teach others. 🧠

[Sarah C.P. Williams @sarahcpwilliams]

New work in @NatureComms by @Mo_Li_KAUST, @BLY36865709 & colleagues at @KaustResearch and @salkinstitute reveals RNA splicing defects that underlie the #rarediseases Wiskott-Aldrich syndrome. https://t.co/iRYMf4y002