The Bagni Lab

Research group at @DNF_neuro, Lausanne. We investigate the pathological mechanisms of Autism Spectrum Disorder and Fragile X Syndrome.

[The Bagni Lab @BagniLab]

@organoidscience

[The Bagni Lab @BagniLab]

Our first organoid study is in @EMBO reports!
Controlling fluid dynamics produces organoids with uniform morphology and preserved transcriptional identity across batches and cell lines.
Thanks to @G_Aiello91, Mohamed Nemir, @BarboraVidimova & @CelVivo3D!
https://t.co/2YISmkRjBr

[The Bagni Lab @BagniLab]

Check out our new work on organoids!

Reducing fluid flow shear stress during neural induction, we obtained consistent morphology, cellular composition and metabolic profiles across batches and different cell lines.

https://t.co/cIdAcWHz2Q

@unil @DNF_neuro @BOrganoid

[The Bagni Lab @BagniLab]

Today is International Fragile X Awareness Day, an opportunity to shed light on a genetic condition that significantly impacts individuals and families across the globe.
Let's continue to spread knowledge, raise awareness, and work all towards a brighter future together.

[The Bagni Lab @BagniLab]

We explored the impact of CYFIP1 gene variants on NDDs using flies and fibroblasts. Our research revealed disruptions in the wave regulatory complex, impacting processes such as actin polymerization and brain morphology.
Published in @BiologicalPsyc1 🪰
https://t.co/gPNWJFyGDA

[The Bagni Lab @BagniLab]

We are very happy to welcome Kyriaki to our lab! Kyriaki joins us to investigate mutations in ASD-linked genes using Drosophila melanogaster. Her expertise in genetics and molecular pathways makes her a great asset to take our research on #ASD a step further.🪰

[The Bagni Lab @BagniLab]

Unique Opportunity at Claudia Bagni's Lab: Seeking a Passionate and Dedicated Laboratory Technician! 🌟 Join Our Team

[The Bagni Lab @BagniLab]

Crafted from real-life experiences, 'Instants (x) Fragiles,' a poignant play by the Compagnie Essentiel Ephémère supported by the @FrenchFragileX association sheds light on the challenges of #FragileXSyndrome. Teaser here https://t.co/wQ9PYybhAU.

[The Bagni Lab @BagniLab]

Exciting news! Our review on repurposing cancer drugs for #ASD treatment is out in @TrendsinPharma @CellPressNews .
Discover new #TherapeuticStrategies in #neurodevelopment. Read for free  https://t.co/vxHA3BPi88 until 26/12/23.
#Neuroscience #Innovation @DNF_neuro @FBM_UNIL .

[The Bagni Lab @BagniLab]

Recently awarded CAVALIERE O.M.R.I. - Knight of the Order of Merit of the Italian Republic. Grateful to all my mentors, students and colleagues for contributing to my academic journey. Honored by President Mattarella for my work on #FragileXSyndrome and #Autism. Thank you all!

[VMariano @VMariano3]

Very honored and grateful!! 🤩Merci à la @FBM_UNIL!! 🙏🏻 I couldn’t have achieved this without the support of my mentors and colleagues from @BagniLab, family and friends who have believed in me every step of the way! Felicitations à tous!! 🍾🎉

[The Bagni Lab @BagniLab]

Two open postdoc positions at @BagniLab @DNF_neuro! We are seeking for motivated candidates to investigate the mechanisms underlying neurodevelopmental deficits using🪰and 🐭. #postdoc #neuroscience #DNF
Send CV, Cover letter and 3 referees by August 1st, 2023 (see ad).

[The Bagni Lab @BagniLab]

Interested in understanding what modulates striatal flexibility? Here is our paper in @NeuroCellPress on FXS! https://t.co/QDmYdy8hVR

Congrats to @valemercaldo, all the coauthors and @BagniLab .
@DNF_neuro @FBM_UNIL @unitorvergata @unil

[Department of Fundamental Neurosciences @DNF_neuro]

Altered striatal actin dynamics drives behavioral inflexibility in a mouse model of fragile X syndrome - New article on @NeuroCellPres from the @BagniLab

https://t.co/43W4NUleXv

@FBM_UNIL @unil @unitorvergata @LndsNeuro @NeuroLeman

[Università di Roma Tor Vergata @unitorvergata]

Agire sull'area cerebrale dello #striato per migliorare i #disturbi #comportamentali legati all’ autismo e alla sindrome dell'X fragile (FXS). Nuovi meccanismi molecolari e nuove speranze terapeutiche nello studio di @BagniLab su @NeuroCellPress @unil

https://t.co/nIFVG4e5P1

[The Bagni Lab @BagniLab]

Press release: https://t.co/kqbhfpeeiR

[The Bagni Lab @BagniLab]

We are happy to share that our latest work on Drosophila melanogaster 🪰 and sleep is now out in @naturecomms!! Congrats to @VMariano3 , the whole team and all the @bagniLab. https://t.co/4ft3Ieslj5. Highlights in the thread.

[The Bagni Lab @BagniLab]

Finally, we demonstrated that modulation of SREBP or the Malic enzyme was sufficient to ameliorate sleep deficits in Cyfip heterozygous flies. The work suggests modulation of the SREBP metabolic axis as a new avenue worth exploring for its therapeutic potential in sleep disorders

[The Bagni Lab @BagniLab]

3. Furthermore, we showed that the over-activity of SREBP and one of its targets, the Malic enzyme, cause sleep deficits in Cyfip mutant flies via dysregulation of the brain NADP+/NADPH ratio.