basebybase

Where genomics meets sound. Music & podcasts inspired by research.

[NEJM @NEJM]

In the phase 3 TRIUMPH-1 trial involving participants with obesity, retatrutide, a triple hormone receptor agonist, resulted in substantial weight reduction and a decrease in knee osteoarthritis pain and obstructive sleep apnea events. Full trial results and Research Summary: https://t.co/RyCnPv4grV

[Marco Demaria @marc_dema]

@BasebyBasePod @embojournal Very nice, thank you

[basebybase @BasebyBasePod]

@AJHGNews ▶️ Watch the video version on YouTube: https://t.co/8vWa7kcusx

[basebybase @BasebyBasePod]

A lab score for 9,225 TP53 mutations tracked real cancer risk: in 437 people with Li-Fraumeni syndrome, high-scoring variants were associated with earlier cancer. @AJHGNews

👇 Link to the full episode in the first reply.

[basebybase @BasebyBasePod]

@AJHGNews 🎧 Listen to the full episode, with transcript and sources: https://t.co/K0SgLXjHky

[basebybase @BasebyBasePod]

@AJHGNews ▶️ The 3-minute version, with original animations: https://t.co/jyp3PT7ktm

[basebybase @BasebyBasePod]

Same gene, very different risk 🧬

A cell score that predicts cancer risk in Li-Fraumeni syndrome, in 3 minutes with original animations.

📄 Penkert et al. · AJHG, 2026 · CC BY 4.0
🎧 Full episode: https://t.co/K0SgLXjHky

[basebybase @BasebyBasePod]

Same damage, different risk? 🧬

Two collagen genes, two different risks, in 3 minutes with original animations.

📄 Tzoumkas et al. · AJHG, 2026 · CC BY 4.0
🎧 Full episode: https://t.co/9D8SR3VSz0

[basebybase @BasebyBasePod]

Why do cells stop dividing? 🧬

Cellular senescence, six decades of discovery, in 3 minutes with original animations.

📄 Klaver et al., The EMBO Journal, 2026 · CC BY 4.0
🎧 Full episode: https://t.co/Rqtpb3GqWG

[basebybase @BasebyBasePod]

@AJHGNews ▶️ The 3-minute version, with original animations: https://t.co/pOpXjD5w4u

[basebybase @BasebyBasePod]

COL4A3 and COL4A4 build the same kidney collagen, yet truncating and NC1 variants are far more harmful in COL4A4, in over 900,000 people. @AJHGNews

👇 Link to the full episode in the first reply.

[basebybase @BasebyBasePod]

@embojournal @marc_dema ▶️ The 3-minute version, with original animations: https://t.co/14nGsBoFKq

[basebybase @BasebyBasePod]

Sixty years after the Hayflick limit, cellular senescence looks less like an endpoint and more like a context-dependent program, and trials still lack validated biomarkers. @embojournal @marc_dema

👇 Link to the full episode in the first reply.

[basebybase @BasebyBasePod]

@AJHGNews ▶️ Watch the video version on YouTube: https://t.co/lxx972UEWf

[basebybase @BasebyBasePod]

@AJHGNews 🎧 Listen to the full episode, with transcript and sources: https://t.co/9D8SR3VkJs

[basebybase @BasebyBasePod]

@embojournal @marc_dema ▶️ Watch the video version on YouTube: https://t.co/C6E8nEavoo

[basebybase @BasebyBasePod]

@embojournal @marc_dema 🎧 Listen to the full episode, with transcript and sources: https://t.co/Rqtpb3FT78

[basebybase @BasebyBasePod]

@NatureGenet ▶️ Watch the video version on YouTube: https://t.co/CQX2Tg8Y3I

[basebybase @BasebyBasePod]

A haplotype panel from 490,319 UK Biobank genomes improved imputation in most populations tested and sharpened a COVID-19 signal at 3p21.31 in Italian data. @NatureGenet

👇 Link to the full episode in the first reply.

[basebybase @BasebyBasePod]

@NatureGenet 🎧 Listen to the full episode, with transcript and sources: https://t.co/OfIVrHZWjJ