I created this visual summary of the TCGA molecular subtypes of gastric adenocarcinoma, highlighting their key molecular features, typical locations, frequencies, and prognostic differences.
Splenic marginal zone lymphoma➡️look for these 2 zones:
🩸Central zone of small lymphocytes replacing reactive germinal centers
🩸Peripheral zone of small/medium-sized cells with abundant pale cytoplasm, resembling marginal zone cells
#hemepath#lymsm#PathTwitter#MedTwitter
The art of grossing. A 56 yo woman with palpable left breast tumor which was proven to be “fibroepithelial tumor”on histology. Final DX.Left Total Mastectomy: 12x9 cm, Borderline Phyllodes Tumor. #pathology#pathres#pathTwitter#Breast#Cancer
An awesome case to start 2025
71M, retroperitoneal mass/adenopathy. No other lesions.
Round cells of intermediate size,
Scant cytoplasm,
Clumped chromatin,
Very isolated nucleoli, mitosis.
What do you think? 🤔🤔
@SECitologia@IACytology@CytologyEFCS@aakasharmand@mtsiddi
Progressive transformation of germinal centers #PathTwitter
- Characterized by enlarged nodal lymphoid follicles with ingress of mantle zone B cells into the germinal centers.
- Associated with previous, concurrent or subsequent lymphoma, particularly NLPHL.
“Cholangiocarcinoma” on a liver FNA, simulating a neuroendocrine tumor (such as metastatic PanNET) due to a remarkable single cell plasmacytoid appearance.
1/ A 70-year-old man presents with a fever of unknown origin, fatigue, and neurological symptoms mimicking stroke. Imaging shows no lymphadenopathy. What’s the diagnosis (see images)?
Muscle from a 5-month-old with cardiomyopathy & diffuse hypotonia, diagnosis?
A) Lysosomal disorder
B) Mitochondrial disorder
#BSTPath #PathTwitter #Pathology #PediPath
The answer was tall cell carcinoma with reversed polarity (TCCRP).
TCCRP may show morphologic overlap with other papillary lesions, but is distinguished by its striking reversed arrangement and papillary thyroid carcinoma-like nuclear features.
#PathTwitter#PathX#breastpath
Gastric MALToma Treatment🧩
📚Type of marginal zone lymphoma
💊If confined to stomach +/- local lymph node spread
➡️ Abx 💊 to treat H Pylori infection
IF🧬 t(11;18), 💊 Abx AND radiation☢️
➡️ If NEG for H Pylori, radiation ☢️
#pathx#medicine#gipath
Questions to pathologists in training and practicing pathologists:
What are your pain points in breast pathology?
In what areas do you think your training and available textbooks did not offer you sufficiently clear information?
What would you really like to have as a resource that you don't currently have?
I would love to hear your thoughts. Please share them with reckless abandon :)
@wusm_pathology @washupathedu #PathTwitter #breastpath