Important work by @markgbaxter & @nickdownleft demonstrating dose dependent working memory impairments of commonly used DREADD ligands. #chemogenetics
Check out our recent studies investigating THC's effect on rodent development in terms of pyramidal neuromorphology and transcriptional underpinnings. https://t.co/DjzVwFDu3a #preclinical#openaccess@SinaiBrain@MolPsychiatry
Behavioral effect of chemogenetic inhibition is directly related to receptor transduction levels in rhesus monkeys https://t.co/9AfpFCq5fb new in @JNeuroscience!
Timing of cyclic estradiol treatment differentially affects cognition in aged female rhesus monkeys https://t.co/oZFpE2rnvC New in Online First Publication!
Behavioral effect of chemogenetic inhibition is directly related to receptor transduction levels in rhesus monkeys https://t.co/GlFI2ZjSve #biorxiv_neursci
Persistent alteration in behavioural reactivity to a mild social stressor in rhesus monkeys repeatedly exposed to sevoflurane in infancy https://t.co/X9wA1BiLn2
Quantitative analysis of synaptic pathology and neuroinflammation: an initial study in a female rhesus monkey model of the ... https://t.co/y8Gt8Y4pHw #biorxiv_neursci
@zenbrainest The paper where they targeted putamen showed a correlation of effectiveness with PET measures (clozapine binding IIRC?) but I'm not aware of any stereological quantification