Modeling a NM patient point mutation in Cofilin-2 in vitro and in vivo indicate that both the nucleotide exchange and actin severing functions of Cofilin-2 are impaired. These predict the functional deficits found in Cofilin-2 NM patients.
Congratulations to @BriChristophers for her amazing thesis defense!
Using a fly model of Nemaline myopathy, Bri provides new insights to this disease. Stay tuned for the paper!
PhD down, MD to go!
#devbio @TRiIMDPhD @WeillCornellGS@MSKCancerCenter
Spot me behind the (really large) lectern presenting my thesis work at the 42nd annual Vincent du Vigneaud Research Symposium at @WeillCornell!
@BayliesLab @TriIMDPhD
#DoubleDocs#phd#phdchat
Issue 6 is now complete!
On the cover: a dissected third instar Drosophila larva stained for sarcomeric ZASP-GFP (green) and filamentous actin (phalloidin, red). For more details, see the Research Article by Zapater i Morales et al.
https://t.co/vFHcuuorNJ
Carolina's work also adds support and extends the tension-driven model of myofibrillogenesis. Together this work highlights the multiple places within the multinucleated muscle cell where actin (and Tmod) work to assure optimal muscle function.
Hope that the images from @zapatercarolina (cover @Dev_journal and #FluorescenceFriday) will get you to check out her paper in this issue of @Dev_journal! https://t.co/haRtXWNdQg Tropomodulin loss impacts more than sarcomeres in the growing muscle cell!
... misshaped and internalized nuclei with altered transcription. In collab with P. Carman and R. Dominquez (UPenn), she showed that fly Tmod also acts an actin capping protein. We propose that this function is required at multiple subcellular locations in the muscle cell.
This was so much fun!!
Thank you for including me in this phenomenal group of scientific leaders and thank you @BayliesLab for the heartwarming words!!!! 💪🏻⭐️
#WomenInSTEM#WomensHistoryMonth
@BriChristophers @TriIMDPhD @NICHD_NIH Congratulations Bri! You are amazing and soooo wonderful to have in the lab! You are an inspiration to us all! #WomenInSTEM
You always hear that your PhD cohort should be friendly one but boy, are we at Cornell a family. Exams, experiments, moves, travels, breakups, engagement parties - couldn’t have done first yr without these (and 15 others) BCMBers. ❤️