Read Rosales-Hernandez et al. https://t.co/hGCYjaO1nu and Zerbes/Colina-Tenorio et al. https://t.co/3tl0q05sy0 to find out about delivery of the Rieske protein after Bcs1 transport to Mar26 and MICOS for bc1 complex assembly.
Our results finally explain the essential role of snR30 snoRNA! Check out the details in our preprint to find out more πππ https://t.co/UJ8ib8Miw0
#ribosome#cryoEM#RNA
First structure of a H/ACA snoRNP acting in ribosome synthesis. In a great collaboration with the Hurt lab, we provide a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. πππ
Authors including @jingdongcheng report cryo-EM structures revealing how antibiotic tigecycline can also target human mitoribosome.
https://t.co/HFoYItNpQl
Fresh out of the oven, our collaboration with the Kopito Lab - UFL1(E3) modifies, binds to, and dissociates the 60S subunit from the Sec61 translocon! #ribosome#cryoEM
πWe are thrilled to share our exciting new collaboration with @inada_lab and @jingdongcheng on how Otu2 recognizes and deubiquitinates 40S ribosomes after translation. Here is a thread with the most interesting findings:π #ribosome#ubiquitin#cryoEM
Otu2 can bind to 40S during cytoplasmic ribosome biogenesis and all stages between ribosome recycling and start-codon recognition, but becomes a highly specific enzyme for translational reset during recycling/(re)initiation by removing mono-ubiquitin present on eS7.
Turns out MutS2 just doesnβt cut it βοΈ despite it having an SMR domain! Our latest collaboration with the @BeckmannLab characterizing the role of MutS2 in splitting stalled ribosomes in B. subtilis.
https://t.co/OfAJSzBeOR
Let's rotate! Thanks to the great Hurt lab and @BeckmannLab, our story on the 60S ribosome biogenesis is finally out in EMBO reports. We find the 5S RNP in a new rotate conformation when stably incorporate into the nucleolar pre-60S. #cryoEM#ribosome
https://t.co/w6sIVUGKvw
Its online:π₯³ππ Check out the @MathWorksAI user storyπ»
https://t.co/Ikr9VP8TfG about our (@BeckmannLab, @hopfnerlab) DL based Cryo-EM image analysis tool (https://t.co/wgclFJYrhI). Thank you @MathWorks for the great support!ππ
Keeping up the momentum, we're excited to share the final version of our story about RQT-driven ribosomal splitting π π Shout out to @KaBe__01, @ThomasB08006066, @inada_lab and everyone involved! Read on to learn moreππ»ππ»ππ» #cryoEM#ribosome#RQT
Pull the ripcord to clear the traffic jam: RQT splits collided #ribosomes by engaging the emerging mRNA. Check out our new story at #bioRxiv: https://t.co/JhCklVwKvW
The Ski2-like helicase 1 subunit applies a pulling force on the mRNA which causes RQT to swivel between two conformations. This leads to the destabilization of the 40S subunit, resulting in subunit dissociation of the leading ribosome.