Beisel Lab

Synthetic Biology lab of Chase Beisel at @Helmholtz_HIRI.

Lab logo designed by our own PhD student, Adini Arifah!

[Ylenia Jabalera @YleniaJabalera]

Excited to share our work published in @NatureBiotech! We uncover and characterize a unique and highly versatile ancestral form of CRISPR-Cas12a (ReChb)! A big thanks to the whole team. 🧬

https://t.co/7UgQAzzthP

#SynBioLab @CICbioGUNE @IgorTascon @BeiselLab @FUNDELA1

[Helmholtz Institute Würzburg (HIRI) @Helmholtz_HIRI]

A new research briefing has just been published in @NatureBiotech, summarizing the latest paper from #HIRI's @BeiselLab in collaboration with @YleniaJabalera and Raúl Pérez Jiménez from @CICbioGUNE. Check it out! ⤵️

[Alonso-Stepanova Lab @AlonsoStepanova]

Happy to have been able to contribute to the implementation of this exciting new genome editing tool coming out of the Chase Biesel lab! @BeiselLab

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes https://t.co/LhwrWO9Xhb

[Beisel Lab @BeiselLab]

Exciting stuff happening in microbiome science! Check out Charlotte Kamm's Spotlight article on engineering bacteriophages to deliver gene editors.

[Charlotte Kamm @LK7606531793786]

In my publishing my first Spotlight article era ✨️
@BeiselLab

[Charlotte Kamm @LK7606531793786]

In my publishing my first Spotlight article era ✨️
@BeiselLab

[Beisel Lab @BeiselLab]

Check out the exciting work of @Chunlei_Jiao on the PUMA technology for the precise detection of RNA with DNA-cutting Cas12 nucleases

[Helmholtz Institute Würzburg (HIRI) @Helmholtz_HIRI]

#CRISPRCas systems have become a plentiful source of technologies for molecular diagnostics. #HIRI’s @BeiselLab has now expanded this extensive toolbox. PUMA enables the detection of RNA with Cas12 nucleases, which naturally target DNA. 🧬🐈🧵 Read more: https://t.co/fciWsHg3R8

[Helmholtz Institute Würzburg (HIRI) @Helmholtz_HIRI]

#CRISPRCas systems have become a plentiful source of technologies for molecular diagnostics. #HIRI’s @BeiselLab has now expanded this extensive toolbox. PUMA enables the detection of RNA with Cas12 nucleases, which naturally target DNA. 🧬🐈🧵 Read more: https://t.co/fciWsHg3R8

[Beisel Lab @BeiselLab]

Exciting advance addressing a long-standing challenge: efficiently transforming DNA! Congrats to Justin Vento on his new paper introducing IMPRINT. @Helmholtz_HIRI @ncstatecbe https://t.co/vm2WddxoRx

[Beisel Lab @BeiselLab]

Our brilliant team member, @Chunlei_Jiao will start a new adventure with his own lab at NUS in Singapore next year! A huge congratulations to him on this achievement. #CRISPR #PostdocPositions #PhDPositions

[Chunlei Jiao @Chunlei_Jiao]

Job Alerts, thrilled to announce that I will join NUS in Singapore in July 2024! 2 Postdoc and 4 fully-funded PhD positions available. Join me in this beautiful and vibrant place for #CRISPR and beyond research! If interested, email me or DM. Please RT!!!

[Chunlei Jiao @Chunlei_Jiao]

Job Alerts, thrilled to announce that I will join NUS in Singapore in July 2024! 2 Postdoc and 4 fully-funded PhD positions available. Join me in this beautiful and vibrant place for #CRISPR and beyond research! If interested, email me or DM. Please RT!!!

[Helmholtz Institute Würzburg (HIRI) @Helmholtz_HIRI]

(1/2) 🚨 Check out @BeiselLab’s recent work in @NAR_Open reporting new Anti-CRISPR proteins. They were discovered in a bacterial #pathogen with two extensively self-targeting Type I #CRISPR-Cas systems, and the Acrs block #DNA degradation but not DNA binding.

[Helmholtz Institute Würzburg (HIRI) @Helmholtz_HIRI]

(2/2) For those and many more intriguing findings, including unexpected homologs, see 👇https://t.co/wpG41dki6Q

[Peter Fineran @PeterFineran]

Such as pleasure to host @BeiselLab as a #ChafferFellow @otago @microtago. An amazing tour de force talk today titled “#CRISPR: a bottomless well of discovery and innovation”

[Deniz Durmusoglu @DenizDurmusogl1]

Having trouble with transforming your favorite bacteria with valuable genetic cargo? Try IMPRINT🙌🏻! A sophisticated TXTL-based pipeline developed by @JustinVento @BeiselLab
Fun and long-lasting collaboration between @nathanguy14 @BeiselLab members! Grateful to be part of it☺️

[bioRxiv @biorxivpreprint]

A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria https://t.co/V0Lratyd0R #bioRxiv

[Helmholtz Institute Würzburg (HIRI) @Helmholtz_HIRI]

Listen up, #CRISPR Fan(zor)atics! ✂️🧬 In a new @MolecularCell spotlight, @BeiselLab's @copa_bio recaps @zhangf's recent remarkable discovery describing eukaryotic #RNA-guided DNA endonucleases, called Fanzors. Read more here: https://t.co/y9GDDbLBl5

[Helmholtz Institute Würzburg (HIRI) @Helmholtz_HIRI]

#CRISPR arrays are a compact way for nature to encode #gRNAs, but their ability to acquire new spacers keeps them longer than necessary for CRISPR technologies. #HIRI's @BeiselLab now shows that CRISPR-Cas9 arrays can be shortened without compromising: https://t.co/aTpjRz6zm0

[Peter Fineran @PeterFineran]

Great way to round out @crispr2023 #crispr with the conference dinner at the Wurzburg Residence!

[Peter Fineran @PeterFineran]

Did you enjoy @crispr2023 or want to come to the next one! The #crispr conference will be in ⁦@Christchurch_NZ⁩ organised by ⁦@PeterFineran⁩, ⁦@dsashital⁩ ⁦@gavinjknott⁩ and ⁦@drbridgetwatson⁩. Check out the website https://t.co/pQAFHU68Dw

[Beisel Lab @BeiselLab]

Our postdoc @Chunlei_Jiao presented his recent findings at #CRISPR2023 today. If you have the chance also look at posters number 41, 43, and 48 from other lab members @katwandu @AngelaMigur @Okrety_MD