It was only a matter of time: Phosphorus(V) gets "radicalized".
Appearing today in @ChemRxiv, access to new chemical space through the first stereocontrolled radical reactions of P(V): https://t.co/6l1rF09cSP . Another awesome collaboration with the team at BMS.
Copper-Catalyzed Dynamic Kinetic Asymmetric P-C coupling of Secondary Phosphine Oxides and Aryl iodides (Su and co-workers) @subohxx@NKU1919 https://t.co/kbdtH8NUsw
Today in @ChemRxiv (https://t.co/cKhuyQGCzu): Democratized access to stereo pure thioisosteres of life's building blocks with promising translational potential in medicine. New reagents and a completely different strategy coupled to some amazing collaborators enabled this study.
Our new @Mechanochem paper is out in @angew_chem! Here we show that mechanochemistry allows the generation of calcium-based heavy Grignard reagents (Ar–CaX) from commercially available, unactivated calcium metal. Congrats to the team!!
https://t.co/vPoWGcp68z
Check out this awesome work by @KCFchemistry on the catalytic, enantioselective synthesis of a P(V) building block!!! Read all about chlorophosphonamidates, phosphonamidates, phosphinamidates, phosphonates, phosphinates, and phosphonamidothioates!
https://t.co/58i8iJYOBY
I am really happy to share our latest paper, Resolution of aryl-H-phosphinates applied in the synthesis of P-stereogenic compounds including a Brønsted acid NMR solvating agent, which is accepted for publication in Organic Chemistry Frontiers https://t.co/wQdIr04Qiz
Cobalt-Catalysed Asymmetric Addition and Alkylation of Secondary Phosphine Oxides for the Synthesis of P-Stereogenic Compounds (Duan) @SNNUChina https://t.co/kdl0WM5E9h
Just out in #JOC two-for-one from the Denmark group, Lewis Base-catalyzed, sulfur-boosted chemistry for making stuff. See the back-to-back articles https://t.co/dQaP5Q5ixM and https://t.co/zDbN8K9MEo
I am happy to announce that our latest work on the enantioseparation of secondary phosphine oxides appeared in @JOC_OL
Huge thx to @BenceVarga9, Peti, Petra and Réka for the synthetic work, and Tamás for the X-ray. I am proud to be the part of this team!
https://t.co/N66EaxmyfV
ICYMI, in our #ChemSciPicks@pmaity2 and @KumarVanka1 of @csir_ncl form 2-alkylpyridines using alkyl amines. An achiral phosphite and a base trigger a smart and stereoretentive 1,2-rearrangement of the alkylpyridinium salt! Read in full for free here 👉https://t.co/j9qPi287Nt
In 2016, with @EastgateMartin and the @bmsnews team we set out to simplify the way Oligonucleotides therapeutics (OTs) are made. Access to a 3-10-3 LNA/DNA gapmer with 4 different P-linkages had pushed the limits of known chem. Today we report a solution: https://t.co/hSsZXFg3DJ
We tried to settle a highly heated debate here on twitter. This is how a research topic is born :).
Pd impurities can be present after chromatographic purification and catalyze Suzuki coupling. See on ChemRxiv: https://t.co/GM9amzzm3v
NEW #ASAP! Phil Baran @BaranLabReads, Philip Dawson & co-workers @scrippsresearch present the development of synthetic elaboration of native DNA by reversible adsorption of solid support (SENDR) & demonstrate its utility: https://t.co/PA1hEkB9IG