Ben Lake

Researcher🧪| Approaching biological inquiries with chemical intuition #Chemicalbiology | Shawarma Fanatic | Nerd | Dog Stepdaddy

[Dan Nomura @DanNomura]

Covalent molecular glue degrader of BRD4 from Gray, Ebert, Fischer labs: Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders | bioRxiv https://t.co/qjUNWzTT64

[Nature Chemical Biology @nchembio]

A new paper from @DrorLab, @MIPS_Australia uses atomic-level simulations to reveal a molecular mechanism by which a ligand can achieve selectivity between nearly identical receptors, enabling the rational design of targeted drugs. Open access: https://t.co/gZ7foMmotU

[Covalent Modifiers @CovalentMod]

Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome https://t.co/r2QS0iUR42

[Erica Quilates @ericaquilates]

Interesting work around creating “PHORCs”, phosphatase recruitment chimeras. There’s soooo much potential in the concept of dephosphorylating proteins, I believe we can do more with such technology over time https://t.co/OYYNhkkwFP