Check out the pre-print for the influence of alpha cells on islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this!
BiorXiv:
Islet GLP1-R signaling has 2x effect on 1st phase amplitude, 4x effect on frequency of Ca2+ oscillations (proxy for 2nd phase insulin secretion), 1st responders, and hubs - all without gut - derived GLP. Alpha cells & glucagon are main suspects.
https://t.co/wy8T5gV0FJ
BiorXiv:
Islet GLP1-R signaling has 2x effect on 1st phase amplitude, 4x effect on frequency of Ca2+ oscillations (proxy for 2nd phase insulin secretion), 1st responders, and hubs - all without gut - derived GLP. Alpha cells & glucagon are main suspects.
https://t.co/wy8T5gV0FJ
Imagine what would happen today if @doge posted on @x there was a study “testing the venom of Gila monsters to determine if they can cure diabetes “.
https://t.co/QsSMpFC2iz
Collins and Farnsworth provide an overview of the use of nanocarriers for cell-targeted delivery and the current state of the field of beta cell targeting.
https://t.co/2q0vKq31nQ
Wow! Mathematical modelling of insulin secretion, integrating many upstream and downstream processes - including dual effects of H2O2 and NADPH (and SENP1) at distinct points in secretion. From some colleagues in Maribor.
https://t.co/dFE9Qtl8LC
Check it out- this was a great collaboration with
@merrinslab
and great work from Erli and
@JenniferKBriggs. Come see our talk too, at EASD on the Thursday 12th Sept.
Our new preprint presents 3D light-sheet imaging of the intact islet, focusing on β-cell subpopulations that lead and coordinate islet Ca2+ oscillations. Great collaboration between Erli Jin, @JenniferKBriggs, and @BennyScience . https://t.co/1j7mCFDrZP
I’m thrilled to announce I am joining the Barbara Davis Center for Diabetes at @CUAnschutz! I can’t wait to bridge our prior work on metabolic and epigenomic regulation of beta cell (mal)adaptation into the T1D space. I’ll be recruiting at all levels—reach out if interested!