Bauer Bernd

PhD Student @ Max Perutz Labs studying selective autophagy

[Bauer Bernd @BerndBaub]

Super happy to see my PhD work with @martens_sascha out in @embojournal. A big thanks to everyone involved and also to @EMBOPress for the smooth revision process!
#Autophagy #MaxPerutzLabs #VBC

For more infos see the paper & my previous tweetorial:
https://t.co/8rE0u4an9o

[bioRxiv Cell Biology @biorxiv_cellbio]

TAX1BP1 recruitment reactivates autophagy of Tau aggregates through ULK1 and TBK1 https://t.co/MspawLw1TJ #biorxiv_cellbio

[Max Perutz Labs Vienna @MaxPerutzLabs]

Exciting news! ✨ Sascha Martens is proud to continue the journey with the Aligning Science Across Parkinson’s Initiative (ASAP), as their funding has been extended! The global collaboration has been exploring the crucial link between mitophagy and PD💡 ➡️ https://t.co/xYKs2qqcCR

[The EMBO Journal @embojournal]

Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestration
Bauer Bernd @BerndBaub, Sascha Martens @martens_sascha et al @MaxPerutzLabs
https://t.co/zMmeBofho2

[Bauer Bernd @BerndBaub]

@zaffagg3 @martens_sascha @embojournal @EMBOPress Thanks Gabri! 😄

[Bauer Bernd @BerndBaub]

Super happy to see my PhD work with @martens_sascha out in @embojournal. A big thanks to everyone involved and also to @EMBOPress for the smooth revision process!
#Autophagy #MaxPerutzLabs #VBC

For more infos see the paper & my previous tweetorial:
https://t.co/8rE0u4an9o

[Max Perutz Labs Vienna @MaxPerutzLabs]

🚨 Out now! Bernd Bauer and the @martens_sascha lab reveal in @embojournal how the cargo receptor TAX1BP1 faciliates the switch from cargo collection to sequestration, a process crucial for aggrephagy - the cell's way of recycling aggregated proteins ♻️ ➡️ https://t.co/NVnlu9JNeT

[Cell Biology J-Club @cell_club]

Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestration | The EMBO Journal https://t.co/cvAFAphBp5

[Bauer Bernd @BerndBaub]

@deneke_v Thanks Victoria :D

[Bauer Bernd @BerndBaub]

@PlantoPhagy @martens_sascha Thanks Yasin! 😊

[Victoria Deneke @deneke_v]

The life of each one of us began when a sperm and an egg came together. But what actually happens at a molecular level?
Our latest work @PauliGroup @CellPress reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/8)
https://t.co/FT5oxJb1dx

[Bauer Bernd @BerndBaub]

A big thank you to the jury for selecting my poster for the EMBO poster prize at the #EMBOautophagy 2024, and to #EMBO for sponsoring the award. A special shoutout to the organizers for putting such a fantastic event together @martens_sascha @KnVelsrud @AntonellaDeMat4

[Max Perutz Labs Vienna @MaxPerutzLabs]

🚨 New paper in @embojournal! The Karagöz lab has uncovered how IRE1, a crucial transmembrane protein, responds to protein folding stress in the ER and reveals that disordered regions in the luminal sensor domain play a vital role in its self-assembly ➡️ https://t.co/StI5I9QlF5

[Elias Adriaenssens @EliasAdriaensse]

Super happy to see the final version of our paper on the role of NAP1/SINTBAD in PINK1/Parkin mitophagy!

@NatureSMB

Read the full paper here: https://t.co/hCIaVNR6kg

[Luca Ferrari @FerrariiLuca]

Out on @ScienceAdvances our paper describing how Alzheimer's Tau fibrils escape autophagy quality control! https://t.co/dPPYzwEgWe🧵below, featuring some challenging biochemistry on patient-derived protein aggregates

[Max Perutz Labs Vienna @MaxPerutzLabs]

🆕 publication! Aggregates of Tau proteins are seen in Alzheimer's 🧠 @FerrariiLuca, postdoc with @martens_sascha, shows in @ScienceAdvances how monomeric and pathological Tau are targeted differently by the autophagy machinery ➡️ https://t.co/fqcXFh9UyK
@univienna @MedUni_Wien

[Women in Autophagy @WAutophagy]

Interesting Journal Club. #Faa1!!!

[Bauer Bernd @BerndBaub]

I am super grateful to my co-authors and all other people that helped and supported me throughout this study. A big thanks of course goes to my PhD supervisor @martens_sascha.

This study was supported by the @FWF

@MaxPerutzLabs @univienna @VBC @VBCPhDProgram @SMICH

[Bauer Bernd @BerndBaub]

Excited to share our latest preprint on how the switch from cargo collection to its sequestration in autophagosomes is regulated in aggrephagy #Autophagy #Biochemistry #CellBiology

Out now on @biorxivpreprint

https://t.co/8oSK6oLdgU
1/10

[Bauer Bernd @BerndBaub]

In summary, TAX1BP1 recruitment is negatively regulated by GABARAP and positively by ubiquitin on the cargo. It might act as a ubiquitin sensor, joining p62 condensates once enough cargo is collected, and promotes autophagosome biogenesis by recruiting autophagy proteins.
10/10