E. coli engineered to become stem cells that differentiate! We prevent take-over by mutant stem cells that only self renew - by linking differentiation to an essential function. A new way to engineer stable microbial communities.
https://t.co/GW9XXWNYVg
“Ten years ago I was kicked out and forced to retire.”
Our new medicine laureate Katalin Karikó (@kkariko) told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges.
Ten years ago, Karikó was still doing all her experiments by hand but today she has been awarded the medicine prize for her research on mRNA, which led to the development of COVID-19 vaccines.
Listen now:
Chandrayaan-3 Mission:
'India🇮🇳,
I reached my destination
and you too!'
: Chandrayaan-3
Chandrayaan-3 has successfully
soft-landed on the moon 🌖!.
Congratulations, India🇮🇳!
#Chandrayaan_3#Ch3
@CVLab_IISERM@IiserMohali Thank you @indranilb4u sir and @CVLab_IISERM members for encouraging me to take up challenges and inspiring me to strive for pursuit of knowledge. Your committment and passion will always be a source of inspiration. I am truly grateful to you & all the CVLians😊
Cheers to my journey @iisermohali. This expedition has been a self-discovery-an exploration of the ups and downs, the serendipitous connections I stumbled upon and my inspiring mentors. Embracing the next chapter with gratitude & in pursuit of a braver, wiser and truer self.
What an amazing feeling to see my MS students (Prince, Pranjal, Yashvi, Mirudula & Sunny) graduate today at the Convocation of @IiserMohali. I'm so incredibly proud of you. My best wishes to you as you set off for the next level of your academic pursuit abroad. Keep rocking!
A mind-blowing paper has come out today in @Nature
In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (https://t.co/Rk8oZJ0bUj).
Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome.
The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.
Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell.
When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part.
The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival.
The conclusion of the paper is metaphorically a quote from the Jurassic Park movie:
“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (https://t.co/UlxRlb86CT)
https://t.co/zA9OAqSoAu
I've spent the past year on a passion project, asking: When it comes to understanding the brain, what are we trying to achieve? What have we learned? What challenges do we face? And what's our plan? As I pull it all together into a book, I want to champion these 11 references:
You're special to The Mind Gala, and we want all your interactions in the science world to run smoothly. To make this happen, we've brought you a brand new event in the Mind Gala series!
@95Shriya@SiddhrthKnkaria@SomdattaKarak
A tree that predated us all, gave shade, peace and was home to many was removed to make home for many others.
We didn't consult anyone to seek solutions and the voices raised, did not matter.
I will continue to teach #Ecology in classrooms and weep at the irony.
RIP dear tree.
"When I became a graduate student, I made a point of treating the undergraduates I supervised the way I wish I’d been treated." https://t.co/8M0i1fzX1W #NationalMentoringMonth
We are glad to announce that @prjctencephalon and @poonam_thakur6 are organizing The Mind Gala, supported by @IndiaBioscience! Join us in the celebration of all things Neuroscience. 🧠🎉
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