Biobayes

Shaping messy biology into structured datasets.

[Biobayes @BioBayes]

I think I finally figured it out. The market can remain irrational longer than I can stay alive.

[vittorio @IterIntellectus]

it really is astonishing what one can achieve by simply arresting criminals

imagine if crime was illegal

[🌸FLOWER CHILD VT🌸 @VT5210]

The female cop's nails turning the surgery glove into a claw, dear lord. Trump assassination attempt level photo.

[Biobayes @BioBayes]

@serialunrigger @IterIntellectus 😂

[Maila Maria Rosa @MailaMariaRosaa]

Worth noting that since Donald Trump & Marco Rubio shut the USAID program down not a single country in Latin America has voted for a Leftist leader again.

Makes you wonder, doesn’t it?

[Biobayes @BioBayes]

@CyberZack42 @NASAAdmin @johnkrausphotos

[Biobayes @BioBayes]

You and me both, my friend

[kache @yacineMTB]

I need more money. Really bad. I might die (implode internally) if I don't figure out how to make more money immediately

[Balaji @balajis]

Western civilization has collapsed before.

But a few scholars preserved the ideas that once made Rome great. They made a backup, and it did eventually come all the way back.

It just took one thousand years.

[Swan @AndySwan]

You're much more of a slave to the 1% that commit 50% of crimes than you are to the 1% that create 40% of the wealth.

[vibe rater @viberater278]

I think people who are very outwardly “woke” tend to actually be shitty people

[Race @multiplanet1]

Elon Musk's ex-girlfriend Grimes once said he lives below the poverty line by choice.

While dating the richest man alive, she watched him live like a broke college student. No house. No possessions. Same meals every day. Sleeping wherever the factory needed him that week. She said she once realized she hadn't seen him eat sitting down in three days.

She said something that stuck with me. He doesn't experience pleasure from things. Not cars. Not houses. Not luxury. The only thing that produces visible joy is progress. A rocket landing. A production target hit. His face would change when a test succeeded in a way it never changed for anything else. Including her.

This is why SpaceX sends a stuffed mascot named Asteroid to space. A normal CEO would think it's unprofessional. Musk does it because even a toy leaving Earth is progress. The mission includes everything. Even play.

Most people work to fund comfort. The comfort becomes the point. The work becomes the cost. Musk eliminated the gap entirely. Every dollar, every hour goes to the mission. Nothing leaks.

The thing you think you want is not the thing that makes you extraordinary. The willingness to stop wanting it is.

[Scyan @ScyanYT]

Homelander was never truly the villain of The Boys.

He was abused, tortured from birth, hurt non stop psychologically manipulated his brain wired in a way to be obedient since birth.

He was a victim to a corporation trying to make the ultimate money making weapon. He was product of evil people while its said in the show itself, he never really wanted to be the best, the strongest. It was forced on him

If he got tortured his entire life to be the best, be the most loved? Do u really expect him not to act the way he did?

The boys finale trying to focus on humiliating him was stupid. All that character development of talking about how homelander could have truly been a superman, if he was not abused his entire life

Just so in the end no proper meaningful end happens to that part of his story

The boys writers should never write a show ever again. They care more about making fun of people instead of writing an actual character

I feel bas for Antony Starr. His insane performance deserved a proper writing❤️legendary acting, horrible writers ruining his masterpiece

[Paul Anleitner @PaulAnleitner]

The Boys represents everything alluring and ultimately unfulfilling about postmodern ideology.

It tells you that “good and evil” is a lie by the powerful.

The powerful are always “oppressors” and the ultimate goal is to expose them and take their power.

But there’s a major problem…

What do you do after exposing Homelander?

Who fills the vacuum? If power is inherently oppressive, you’ll be rebelling and deconstructing again.

And again…and again…

David Foster Wallace called it living as “third world rebels.” You get stuck in permanent revolution mode. Always cynical. Always living in chaos.

Never building something better. Never aspiring to be Superman, because Superman can’t be trusted.

It’s an ultimately hopeless and nihilistic ideology that ruins lives.

[Dvorstone @dvorstone]

The humiliation of the villain is a sign of sadism from the culture that savors it.

Homelander is truly a villain but he was used to pain and suffering and was filled with rage. He would not have begged and pleaded for life. The show's portrayal is utterly inconsistent with how people like him behave.

It's a sadistic fantasy that betrays the sadistic convictions of the writers. They sought to humiliate the villain, but Homelander isn't real and they are. Ironically, in the end, it is the showrunners themselves who end up being the show's true villains.

[vittorio @IterIntellectus]

triple men's salaries and this problem disappears overnight

it's unfortunate, and makes people uncomfortable when talking about it, but to fix fertility rates, make kids and families healthier, woman happier, and fix society, you must maximize gender inequality

[Riley Brown @rileybrown]

Wait... You can build a swift iOS apps from iMessage...

And then download it straight to your home screen?

And it works in Codex as well? Wow

[Tactikal Templar @TemplarsRoar]

Eric Kripke knows that if he were ever in that situation, he would act more like Homelander and not Trump... and that is part of what makes these communists so furious.

[BigCharles_06 @Charles36138349]

I think my respect for Starr has just shot up into the stratosphere.
Dude was genuinley trying to put work into making his character unique/intimidating and Kripke at every point was like, "but how can we tie this back to TRUMP????"
And Anthony was the one to pull him back.

[vittorio @IterIntellectus]

this is literally a million times worse than george floyd

[Bryan Johnson @bryan_johnson]

We now have a female Bryan Johnson.

It’s Kate Tolo.

She will become the most measured female in history.

+$2 million of spend per year
+ Developing a female-specific protocol
+ Sharing everything for free

To start, she will spend 3 months mapping her baseline. Men, in contrast, can get their baseline done in 1 or 2 weeks.

+ 3 months for baseline measurement
+ across 4 time points per cycle
+ doing the same thing every day
+ a dedicated full-time medical team

For context on the extensiveness of measurement, during the past 5 years, we’ve collected 1.5 billion data points on my body. I suspect Kate will exceed that given technology has improved since I started.

The goal is to create a repeatable waveform of hundreds of life-critical biomarkers. Once the baseline is acquired, she will begin interventions.

We will try to answer practically useful questions and share all of the data + learnings for free.

Can fertility be improved?

+ Should women cold plunge?
+ Can PMS symptoms be alleviated?
+ What should a female sauna protocol be?
+ Should dosage change throughout the month?
+ What keeps a cycle regular?
+ Does the body need more iron, magnesium, or protein at specific phases?
+ Should women fast?
+ Should recovery protocol change by phase?
+ What's the earliest detectable signal of perimenopause?
+ Can perimenopause be slowed?
+ How is cognitive load & mood affected?
+ Does stress impact men and women the same?

Kate has suspected endometriosis. 10% of all women do. We will try to tackle this too. I am excited for all of the surprising things we will hopefully uncover.

Unlike me, Kate does not have the innate desire to wake up at 4:30am and do six hours of longevity therapies.

She’s the cofounder of Blueprint, building in the trenches with me since day one. She understands the game and how hard it is.

In many ways, this is a sacrifice for her. She is a creative person, going from a life of freedom and spontaneity to a rigid protocol.

Traditionally, RCTs have been viewed as the gold standard. But RCTs have underserved women. The FDA banned women from clinical trials for 16 years (1977 to 1993), and most "medicine for women" is still medicine tested in men. Demanding RCT-only evidence for women's health is demanding evidence that doesn't exist. There is not enough practical scientific literature for women to reference only RCTs. It leaves half the population without a path to know what to do.

N=1 medicine is gaining ground and picking up where RCTs specifically fail. Individual science experiments give us signals that answer what to do on a day-to-day basis. This is even more important for women.

If you’re new to Kate and my world, I want you to understand that we have your back. Our intentions are to be a sturdy, reliable force in your life. To care for your best interest as we’d care for our own. We want what’s best for you and our loyalty is to your existence.

It’s pretty cool to be living in a time when we may be the first generation to not die. I’m not suggesting immortality, but lifespans so long that we stop thinking about lifespans.

At the end of the day, the one thing we each care about more than anything else is one more breath. I’m proud of Kate for taking on this responsibility. It’s painful, exhausting and costly.

The beginning of the world’s first n=2.